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PMID: 9658142 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Binding of murine leukemia virus Gag polyproteins to KIF4, a microtubule-based motor protein.

Journal of virology ·Vol. 72 ·No. 8 ·1998-08-00 ·Pages 6898-901

Kim W, Tang Y, Okada Y, Torrey TA, Chattopadhyay SK, Pfleiderer M, Falkner FG, Dorner F, Choi W, Hirokawa N, Morse HC

Abstract

A cDNA clone encoding a cellular protein that interacts with murine leukemia virus (MuLV) Gag proteins was isolated from a T-cell lymphoma library. The sequence of the clone is identical to the C terminus of a cellular protein, KIF4, a microtubule-associated motor protein that belongs to the kinesin superfamily. KIF4-MuLV Gag associations have been detected in vitro and in vivo in mammalian cells. We suggest that KIF4 could be involved in Gag polyprotein translocation from the cytoplasm to the cell membrane.

MeSH Terms

Animals Gene Products, gag/genetics,metabolism Kinesins/genetics,metabolism Leukemia Virus, Murine/metabolism Mice Mice, Inbred C57BL Microtubule-Associated Proteins/genetics,metabolism Nerve Tissue Proteins Proteins/metabolism Saccharomyces cerevisiae Viral Proteins/genetics,metabolism

Chemicals

Gene Products, gag Microtubule-Associated Proteins Nerve Tissue Proteins Pr60(gag) protein, murine AIDS virus Proteins Viral Proteins Kif4 protein, mouse Kinesins

Authors & Affiliations

11 authors, click to expand affiliations / ORCID

Kim W

Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA.

Tang Y

Okada Y

Torrey T A

Chattopadhyay S K

Pfleiderer M

Falkner F G

Dorner F

Choi W

Hirokawa N

Morse H C

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Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.72.8.6898-6901.1998

Published

1998-08-00

Pages

6898-901

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC109902

Subset

External Links

PubMed source DOI: 10.1128/JVI.72.8.6898-6901.1998 PMC Full Text View journal details

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Binding of murine leukemia virus Gag polyproteins to KIF4, a microtubule-based motor protein.

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