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PMID: 11104818 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Signal transduction cascades regulating fungal development and virulence.

Microbiology and molecular biology reviews : MMBR ·Vol. 64 ·No. 4 ·2000-12-00 ·Pages 746-85

Lengeler KB, Davidson RC, D'souza C, Harashima T, Shen WC, Wang P, Pan X, Waugh M, Heitman J

Abstract

Cellular differentiation, mating, and filamentous growth are regulated in many fungi by environmental and nutritional signals. For example, in response to nitrogen limitation, diploid cells of the yeast Saccharomyces cerevisiae undergo a dimorphic transition to filamentous growth referred to as pseudohyphal differentiation. Yeast filamentous growth is regulated, in part, by two conserved signal transduction cascades: a mitogen-activated protein kinase cascade and a G-protein regulated cyclic AMP signaling pathway. Related signaling cascades play an analogous role in regulating mating and virulence in the plant fungal pathogen Ustilago maydis and the human fungal pathogens Cryptococcus neoformans and Candida albicans. We review here studies on the signaling cascades that regulate development of these and other fungi. This analysis illustrates both how the model yeast S. cerevisiae can serve as a paradigm for signaling in other organisms and also how studies in other fungi provide insights into conserved signaling pathways that operate in many divergent organisms.

MeSH Terms
Calcineurin/metabolism Cyclic AMP/metabolism Cyclic AMP-Dependent Protein Kinases/metabolism Fungi/cytology,metabolism,pathogenicity GTP-Binding Proteins/metabolism MAP Kinase Signaling System Pheromones Receptor Cross-Talk Transcription Factors/metabolism
Chemicals
Pheromones Transcription Factors Cyclic AMP Cyclic AMP-Dependent Protein Kinases Calcineurin GTP-Binding Proteins
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Lengeler K B
Departments of Genetics, Pharmacology and Cancer Biology, Microbiology, and Medicine, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA.
Davidson R C
D'souza C
Harashima T
Shen W C
Wang P
Pan X
Waugh M
Heitman J
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Article Info
Journal
Microbiology and molecular biology reviews : MMBR
Abbr.
Microbiol Mol Biol Rev
ISSN
1092-2172
DOI
10.1128/MMBR.64.4.746-785.2000
Published
2000-12-00
Pages
746-85
Language
English
Region
United States
NLM ID
9706653
PMCID
PMC99013
Subset
IM
Grants
NIAID NIH HHS · R37 AI039115 · United States
NIAID NIH HHS · R01 AI042159 · United States
NIAID NIH HHS · R01 AI42159 · United States
NIAID NIH HHS · R01 AI039115 · United States
NIAID NIH HHS · R01 AI41937 · United States
NIAID NIH HHS · R01 AI39115 · United States
NIAID NIH HHS · P01 AI044975 · United States
External Links
PubMed source DOI: 10.1128/MMBR.64.4.746-785.2000 PMC Full Text View journal details
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