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PMID: 11716066 Published · ppublish English Journal Article Review

Biological mechanisms of glioma invasion and potential therapeutic targets.

Journal of neuro-oncology ·Vol. 53 ·No. 2 ·2001-06-00 ·Pages 129-47

Tysnes BB, Mahesparan R

Abstract

The current understanding of glioma biology reveals targets for anti-invasive therapy which include manipulations of extracellular matrix and receptors, growth factors and cytokines, proteases, cytoskeletal components, oncogenes and tumor suppressor genes. A better understanding of the complex regulation and the signalling molecules involved in glioma invasion is still needed in order to design new and effective treatment modalities towards invasive tumor cells. Representative and valid in vitro experimental systems and animal models of gliomas are necessary for the characterization of the invasive phenotype and further development of anti-invasive therapy. In the future, it will probably be important to move from comparative genomic modelling through protein characterization based on advanced proteomic techniques to analyse tissue samples, where the aim for gliomas should be to compare invaded and non-invaded tissue. This will hopefully render promising new therapeutic targets for gliomas.

MeSH Terms
Animals Antineoplastic Agents/pharmacology,therapeutic use Astrocytoma/genetics,pathology,therapy Brain Neoplasms/genetics,pathology,therapy Cell Adhesion Molecules/physiology Cell Movement Chromosome Deletion Chromosomes, Human, Pair 10/genetics Cytoskeleton/drug effects,ultrastructure Disease Progression Endopeptidases/physiology Extracellular Matrix/metabolism Forecasting Gene Expression Regulation, Neoplastic Genetic Therapy Glioblastoma/genetics,pathology,therapy Glioma/genetics,pathology,therapy Growth Substances/physiology Humans Integrins/physiology Neoplasm Invasiveness/physiopathology Neoplasm Proteins/antagonists & inhibitors,physiology Neoplasms, Experimental/pathology PTEN Phosphohydrolase Phosphoric Monoester Hydrolases/genetics Protease Inhibitors/pharmacology,therapeutic use Thromboxane-A Synthase/antagonists & inhibitors Tumor Suppressor Proteins/genetics
Chemicals
Antineoplastic Agents Cell Adhesion Molecules Growth Substances Integrins Neoplasm Proteins Protease Inhibitors Tumor Suppressor Proteins Phosphoric Monoester Hydrolases PTEN Phosphohydrolase PTEN protein, human Endopeptidases Thromboxane-A Synthase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Tysnes B B
Department of Anatomy and Cell Biology, University of Bergen, Norway. [email protected]
Mahesparan R
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Article Info
Journal
Journal of neuro-oncology
Abbr.
J Neurooncol
ISSN
0167-594X
DOI
10.1023/a:1012249216117
Email
[email protected]
Published
2001-06-00
Pages
129-47
Language
English
Region
United States
NLM ID
8309335
Subset
IM
External Links
PubMed source DOI: 10.1023/a:1012249216117 View journal details
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