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PMID: 1444339 Published · ppublish English Journal Article Review

The pheromone signal pathway in Saccharomyces cerevisiae.

Antonie van Leeuwenhoek ·Vol. 62 ·No. 1-2 ·1992-08-00 ·Pages 95-108

Konopka JB, Fields S

Abstract

Haploid cells of the yeast Saccharomyces cerevisiae normally undergo a budding life cycle, but after binding the appropriate mating pheromone they undergo a different developmental pathway that leads to conjugation. This intercellular communication between the two mating types activates a signal transduction pathway that stimulates the diverse physiological changes required for conjugation, such as induction of cell surface agglutinins, cell division arrest in G1, morphogenesis to form a conjugation tube, and cell fusion. The components of this pathway include a G protein-coupled receptor, several protein kinases, and a pheromone-responsive transcription factor. The molecular mechanisms that transduce the pheromone signal are remarkably similar to the mechanisms of hormone signaling used in multicellular organisms. Thus, the analysis of the pheromone signal pathway in yeast directly contributes to the study of cell growth and development in other eukaryotic organisms.

MeSH Terms
Conjugation, Genetic/drug effects Gene Expression Regulation, Fungal Morphogenesis/drug effects Pheromones/pharmacology Saccharomyces cerevisiae/drug effects,growth & development Signal Transduction
Chemicals
Pheromones
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Konopka J B
Department of Microbiology, State University of New York, Stony Brook 11794-5222.
Fields S
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Article Info
Journal
Antonie van Leeuwenhoek
Abbr.
Antonie Van Leeuwenhoek
ISSN
0003-6072
DOI
10.1007/BF00584465
Published
1992-08-00
Pages
95-108
Language
English
Region
Netherlands
NLM ID
0372625
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00584465 View journal details
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