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PMID: 15060000 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Evolution and comparative genomics of odorant- and pheromone-associated genes in rodents.

Genome research ·Vol. 14 ·No. 4 ·2004-04-00 ·Pages 591-602

Emes RD, Beatson SA, Ponting CP, Goodstadt L

Abstract

Chemical cues influence a range of behavioral responses in rodents. The involvement of protein odorants and odorant receptors in mediating reproductive behavior, foraging, and predator avoidance suggests that their genes may have been subject to adaptive evolution. We have estimated the consequences of selection on rodent pheromones, their receptors, and olfactory receptors. These families were chosen on the basis of multiple gene duplications since the common ancestor of rat and mouse. For each family, codons were identified that are likely to have been subject to adaptive evolution. The majority of such sites are situated on the solvent-accessible surfaces of putative pheromones and the lumenal portions of their likely receptors. We predict that these contribute to physicochemical and functional diversity within pheromone-receptor interaction sites.

MeSH Terms
Animals Computational Biology/methods Evolution, Molecular GTP-Binding Protein alpha Subunits/genetics GTP-Binding Protein beta Subunits/genetics GTP-Binding Protein gamma Subunits/genetics Gene Duplication Genomics/methods Histocompatibility Antigens Class I/genetics Mice Multigene Family/genetics Pheromones/genetics Rats Receptors, Odorant/chemistry,genetics Receptors, Pheromone/chemistry,genetics Selection, Genetic Vomeronasal Organ/chemistry,metabolism
Chemicals
GTP-Binding Protein alpha Subunits GTP-Binding Protein beta Subunits GTP-Binding Protein gamma Subunits Histocompatibility Antigens Class I Pheromones Receptors, Odorant Receptors, Pheromone
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Emes Richard D
MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK.
Beatson Scott A
Ponting Chris P
Goodstadt Leo
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Article Info
Journal
Genome research
Abbr.
Genome Res
ISSN
1088-9051
DOI
10.1101/gr.1940604
Published
2004-04-00
Pages
591-602
Language
English
Region
United States
NLM ID
9518021
PMCID
PMC383303
Subset
IM
External Links
PubMed source DOI: 10.1101/gr.1940604 PMC Full Text View journal details
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