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PMID: 15690603 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S. Review Corrected and Republished Article

A walk-through of the yeast mating pheromone response pathway.

Peptides ·Vol. 26 ·No. 2 ·2005-02-00 ·Pages 339-50

Bardwell L

Abstract

The intracellular signal transduction pathway by which the yeast Saccharomyces cerevisiae responds to the presence of peptide mating pheromone in its surroundings is one of the best understood signaling pathways in eukaryotes, yet continues to generate new surprises and insights. In this review, we take a brief walk down the pathway, focusing on how the signal is transmitted from the cell-surface receptor-coupled G protein, via a MAP kinase cascade, to the nucleus.

MeSH Terms
Cell Cycle Cell Membrane/metabolism GTP-Binding Proteins/metabolism MAP Kinase Kinase Kinases/metabolism MAP Kinase Signaling System/physiology Models, Biological Pheromones/metabolism Receptors, Cell Surface/metabolism Saccharomyces cerevisiae/metabolism Signal Transduction
Chemicals
Pheromones Receptors, Cell Surface MAP Kinase Kinase Kinases GTP-Binding Proteins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Bardwell Lee
Department of Developmental and Cell Biology, 2208 Natural Sciences I, University of California, Irvine, CA 92697-2300, USA. [email protected]
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Article Info
Journal
Peptides
Abbr.
Peptides
ISSN
0196-9781
DOI
10.1016/j.peptides.2004.10.002
Email
[email protected]
Published
2005-02-00
Pages
339-50
Language
English
Region
United States
NLM ID
8008690
PMCID
PMC3017506
Subset
IM
Grants
NIGMS NIH HHS · R33 GM069013 · United States
NIGMS NIH HHS · GM60366 · United States
NIGMS NIH HHS · GM69013 · United States
NIGMS NIH HHS · R01 GM060366-05 · United States
NIGMS NIH HHS · R01 GM060366 · United States
NIGMS NIH HHS · R21 GM069013 · United States
Corrections
RepublishedFrom
PMID: 15374648
External Links
PubMed source DOI: 10.1016/j.peptides.2004.10.002 PMC Full Text View journal details
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