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PMID: 15731032 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

CD4+ T cells and toll-like receptors recognize Salmonella antigens expressed in bacterial surface organelles.

Infection and immunity ·Vol. 73 ·No. 3 ·2005-03-00 ·Pages 1350-6

Bergman MA, Cummings LA, Barrett SL, Smith KD, Lara JC, Aderem A, Cookson BT

Abstract

A better understanding of immunity to infection is revealed from the characteristics of microbial ligands recognized by host immune responses. Murine infection with the intracellular bacterium Salmonella generates CD4+ T cells that specifically recognize Salmonella proteins expressed in bacterial surface organelles such as flagella and membrane vesicles. These natural Salmonella antigens are also ligands for Toll-like receptors (TLRs) or avidly associated with TLR ligands such as lipopolysaccharide (LPS). PhoP/PhoQ, a regulon controlling Salmonella virulence and remodeling of LPS to resist innate immunity, coordinately represses production of surface-exposed antigens recognized by CD4+ T cells and TLRs. These data suggest that genetically coordinated surface modifications may provide a growth advantage for Salmonella in host tissues by limiting both innate and adaptive immune recognition.

MeSH Terms
Animals Antigens, Bacterial/immunology,metabolism Bacterial Proteins/metabolism CD4-Positive T-Lymphocytes/immunology Cell Membrane/immunology,metabolism Female Flagella/immunology,metabolism Gene Expression Regulation, Bacterial Ligands Lymphocyte Activation Membrane Glycoproteins/immunology,metabolism Mice Mice, Inbred C3H Mice, Inbred C57BL Organelles/immunology,metabolism Receptors, Cell Surface/immunology,metabolism Salmonella Infections, Animal/immunology,microbiology Salmonella typhimurium/immunology,metabolism,pathogenicity Toll-Like Receptors Virulence
Chemicals
Antigens, Bacterial Bacterial Proteins Ligands Membrane Glycoproteins PhoQ protein, Bacteria Receptors, Cell Surface Toll-Like Receptors PhoP protein, Bacteria
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Bergman Molly A
Department of Laboratory Medicine and Microbiology, University of Washington Medical Center, Mailstop 357110, 1959 NE Pacific Ave., Seattle, WA 98195, USA.
Cummings Lisa A
Barrett Sara L Rassoulian
Smith Kelly D
Lara J Cano
Aderem Alan
Cookson Brad T
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/IAI.73.3.1350-1356.2005
Published
2005-03-00
Pages
1350-6
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC1064935
Subset
IM
Grants
NIGMS NIH HHS · T32 GM007270 · United States
NIAID NIH HHS · AI47242 · United States
NIGMS NIH HHS · T32 GM07270 · United States
External Links
PubMed source DOI: 10.1128/IAI.73.3.1350-1356.2005 PMC Full Text View journal details
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