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PMID: 16283514 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Carcinogenic effect of nickel compounds.

Molecular and cellular biochemistry ·Vol. 279 ·No. 1-2 ·2005-11-00 ·Pages 45-67

Lu H, Shi X, Costa M, Huang C

Abstract

Nickel is a widely distributed metal that is industrially applied in many forms. Accumulated epidemiological evidence confirms that exposures to nickel compounds are associated with increased nasal and lung cancer incidence, both in mostly occupational exposures. Although the molecular mechanisms by which nickel compounds cause cancer are still under intense investigation, the carcinogenic actions of nickel compounds are thought to involve oxidative stress, genomic DNA damage, epigenetic effects, and the regulation of gene expression by activation of certain transcription factors related to corresponding signal transduction pathways. The present review summarizes our current knowledge on the molecular mechanisms of nickel carcinogenesis, with special emphasis on the role of nickel induced reactive oxygen species (ROS) and signal transduction pathways.

MeSH Terms
Animals Carcinogens, Environmental/toxicity Cell Transformation, Neoplastic/metabolism DNA Damage Epigenesis, Genetic Humans Mitogen-Activated Protein Kinase 1/metabolism NF-kappa B/metabolism NFATC Transcription Factors/metabolism Nickel/toxicity Reactive Oxygen Species/metabolism Signal Transduction Tumor Suppressor Proteins/metabolism
Chemicals
Carcinogens, Environmental NF-kappa B NFATC Transcription Factors Reactive Oxygen Species Tumor Suppressor Proteins Nickel Mitogen-Activated Protein Kinase 1
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Lu Haitian
Nelson Institute of Environmental Medicine, School of Medicine, New York University, Tuxedo, New York 10987, USA.
Shi Xianglin
Costa Max
Huang Chuanshu
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Article Info
Journal
Molecular and cellular biochemistry
Abbr.
Mol Cell Biochem
ISSN
0300-8177
DOI
10.1007/s11010-005-8215-2
Published
2005-11-00
Pages
45-67
Language
English
Region
Netherlands
NLM ID
0364456
Subset
IM
Grants
NCI NIH HHS · CA094964 · United States
NCI NIH HHS · CA103180 · United States
NCI NIH HHS · CA112557 · United States
NIEHS NIH HHS · ES000260 · United States
NIEHS NIH HHS · ES012451 · United States
External Links
PubMed source DOI: 10.1007/s11010-005-8215-2 View journal details
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