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PMID: 16738560 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

A comprehensive map of the toll-like receptor signaling network.

Molecular systems biology ·Vol. 2 ·2006-00-00 ·Pages 2006.0015

Oda K, Kitano H

Abstract

Recognition of pathogen-associated molecular signatures is critically important in proper activation of the immune system. The toll-like receptor (TLR) signaling network is responsible for innate immune response. In mammalians, there are 11 TLRs that recognize a variety of ligands from pathogens to trigger immunological responses. In this paper, we present a comprehensive map of TLRs and interleukin 1 receptor signaling networks based on papers published so far. The map illustrates the possible existence of a main network subsystem that has a bow-tie structure in which myeloid differentiation primary response gene 88 (MyD88) is a nonredundant core element, two collateral subsystems with small GTPase and phosphatidylinositol signaling, and MyD88-independent pathway. There is extensive crosstalk between the main bow-tie network and subsystems, as well as feedback and feedforward controls. One obvious feature of this network is the fragility against removal of the nonredundant core element, which is MyD88, and involvement of collateral subsystems for generating different reactions and gene expressions for different stimuli.

MeSH Terms
Adaptor Proteins, Signal Transducing Immunity Myeloid Differentiation Factor 88 Receptor Cross-Talk Receptors, Interleukin-1 Signal Transduction Toll-Like Receptors
Chemicals
Adaptor Proteins, Signal Transducing Myeloid Differentiation Factor 88 Receptors, Interleukin-1 Toll-Like Receptors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Oda Kanae
The Systems Biology Institute, Shibuya, Tokyo, Japan.
Kitano Hiroaki
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Article Info
Journal
Molecular systems biology
Abbr.
Mol Syst Biol
ISSN
1744-4292
DOI
10.1038/msb4100057
Published
2006-00-00
Epub
2006-00-18
Pages
2006.0015
Language
English
Region
England
NLM ID
101235389
PMCID
PMC1681489
Subset
IM
External Links
PubMed source DOI: 10.1038/msb4100057 PMC Full Text View journal details
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