Home LiteratureArticle Details
PMID: 21047263 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

The RecQ DNA helicases in DNA repair.

Annual review of genetics ·Vol. 44 ·2010-00-00 ·Pages 393-417

Bernstein KA, Gangloff S, Rothstein R

Abstract

The RecQ helicases are conserved from bacteria to humans and play a critical role in genome stability. In humans, loss of RecQ gene function is associated with cancer predisposition and/or premature aging. Recent experiments have shown that the RecQ helicases function during distinct steps during DNA repair; DNA end resection, displacement-loop (D-loop) processing, branch migration, and resolution of double Holliday junctions (dHJs). RecQ function in these different processing steps has important implications for its role in repair of double-strand breaks (DSBs) that occur during DNA replication and meiosis, as well as at specific genomic loci such as telomeres.

MeSH Terms
Bacteria/enzymology DNA Repair Disease/genetics Genomic Instability Humans RecQ Helicases/chemistry,genetics,metabolism
Chemicals
RecQ Helicases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Bernstein Kara A
Columbia University Medical Center, Department of Genetics & Development, New York, New York 10032, USA. [email protected]
Gangloff Serge
Rothstein Rodney
References (161)
161 references, click to expand
  1. SUMOylation regulates Rad18-mediated template switch.
    Nature. 2008 Dec 18;456(7224):915-20 PMID: 19092928
  2. CHROMOSOMAL BREAKAGE IN A RARE AND PROBABLY GENETICALLY DETERMINED SYNDROME OF MAN.
    Science. 1965 Apr 23;148(3669):506-7 PMID: 14263770
  3. Physical and functional interaction between p53 and the Werner's syndrome protein.
    J Biol Chem. 1999 Oct 8;274(41):29463-9 PMID: 10506209
  4. Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51.
    J Biol Chem. 2001 Jun 1;276(22):19375-81 PMID: 11278509
  5. Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest.
    J Cell Biol. 2004 Sep 13;166(6):801-13 PMID: 15364958
  6. SRS2 and SGS1 prevent chromosomal breaks and stabilize triplet repeats by restraining recombination.
    Nat Struct Mol Biol. 2009 Feb;16(2):159-67 PMID: 19136956
  7. Localization of the Bloom syndrome helicase to punctate nuclear structures and the nuclear matrix and regulation during the cell cycle: comparison with the Werner's syndrome helicase.
    Mol Carcinog. 1999 Dec;26(4):261-73 PMID: 10569803
  8. Novel pro- and anti-recombination activities of the Bloom's syndrome helicase.
    Genes Dev. 2007 Dec 1;21(23):3085-94 PMID: 18003860
  9. BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity.
    EMBO J. 2005 Apr 6;24(7):1465-76 PMID: 15775963
  10. A double Holliday junction dissolvasome comprising BLM, topoisomerase IIIalpha, and BLAP75.
    J Biol Chem. 2006 May 19;281(20):13861-4 PMID: 16595695
  11. RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability.
    Genes Dev. 2008 Oct 15;22(20):2843-55 PMID: 18923082
  12. Syndrome-causing mutations of the BLM gene in persons in the Bloom's Syndrome Registry.
    Hum Mutat. 2007 Aug;28(8):743-53 PMID: 17407155
  13. Histone demethylation by a family of JmjC domain-containing proteins.
    Nature. 2006 Feb 16;439(7078):811-6 PMID: 16362057
  14. The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I.
    J Biol Chem. 1999 Dec 31;274(53):37795-9 PMID: 10608841
  15. p53-mediated apoptosis is attenuated in Werner syndrome cells.
    Genes Dev. 1999 Jun 1;13(11):1355-60 PMID: 10364153
  16. Srs2 and Sgs1 DNA helicases associate with Mre11 in different subcomplexes following checkpoint activation and CDK1-mediated Srs2 phosphorylation.
    Mol Cell Biol. 2005 Jul;25(13):5738-51 PMID: 15964827
  17. PICH, a centromere-associated SNF2 family ATPase, is regulated by Plk1 and required for the spindle checkpoint.
    Cell. 2007 Jan 12;128(1):101-14 PMID: 17218258
  18. The generation of proper constitutive G-tails on yeast telomeres is dependent on the MRX complex.
    Genes Dev. 2004 Jun 15;18(12):1391-6 PMID: 15198981
  19. A test of the double-strand break repair model for meiotic recombination in Saccharomyces cerevisiae.
    Genetics. 1996 Sep;144(1):27-41 PMID: 8878671
  20. Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes.
    Genomics. 1998 Dec 15;54(3):443-52 PMID: 9878247
  21. RecQ helicase, Sgs1, and XPF family endonuclease, Mus81-Mms4, resolve aberrant joint molecules during meiotic recombination.
    Mol Cell. 2008 Aug 8;31(3):324-36 PMID: 18691965
  22. RECQ1 possesses DNA branch migration activity.
    J Biol Chem. 2008 Jul 18;283(29):20231-42 PMID: 18495662
  23. Ubc9- and mms21-mediated sumoylation counteracts recombinogenic events at damaged replication forks.
    Cell. 2006 Nov 3;127(3):509-22 PMID: 17081974
  24. Bloom syndrome ortholog HIM-6 maintains genomic stability in C. elegans.
    Mech Ageing Dev. 2005 Dec;126(12):1314-21 PMID: 16181657
  25. A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity.
    Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13097-102 PMID: 9789047
  26. RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes.
    Nature. 2001 Jul 26;412(6845):456-61 PMID: 11473323
  27. The essential role of yeast topoisomerase III in meiosis depends on recombination.
    EMBO J. 1999 Mar 15;18(6):1701-11 PMID: 10075939
  28. The yeast Sgs1p helicase acts upstream of Rad53p in the DNA replication checkpoint and colocalizes with Rad53p in S-phase-specific foci.
    Genes Dev. 2000 Jan 1;14(1):81-96 PMID: 10640278
  29. Association of the Bloom syndrome protein with topoisomerase IIIalpha in somatic and meiotic cells.
    Cancer Res. 2000 Mar 1;60(5):1162-7 PMID: 10728666
  30. The Bloom's syndrome protein (BLM) interacts with MLH1 but is not required for DNA mismatch repair.
    J Biol Chem. 2001 Aug 10;276(32):30031-5 PMID: 11325959
  31. Nondisjunction Mutants of the Nematode CAENORHABDITIS ELEGANS.
    Genetics. 1979 Jan;91(1):67-94 PMID: 17248881
  32. The spectrum of WRN mutations in Werner syndrome patients.
    Hum Mutat. 2006 Jun;27(6):558-67 PMID: 16673358
  33. Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity.
    J Biol Chem. 2000 Aug 4;275(31):23500-8 PMID: 10825162
  34. Sgs1 helicase activity is required for mitotic but apparently not for meiotic functions.
    Mol Cell Biol. 2000 Sep;20(17):6399-409 PMID: 10938117
  35. JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor.
    Cell. 2006 May 5;125(3):483-95 PMID: 16603237
  36. Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest.
    EMBO Rep. 2000 Jul;1(1):80-4 PMID: 11256630
  37. Functional interaction between the Werner Syndrome protein and DNA polymerase delta.
    Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4603-8 PMID: 10781066
  38. Functional and physical interaction between WRN helicase and human replication protein A.
    J Biol Chem. 1999 Jun 25;274(26):18341-50 PMID: 10373438
  39. Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines.
    Exp Cell Res. 1992 Oct;202(2):267-73 PMID: 1327851
  40. BLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridges.
    EMBO J. 2007 Jul 25;26(14):3397-409 PMID: 17599064
  41. Biochemical characterization of the WRN-1 RecQ helicase of Caenorhabditis elegans.
    Biochemistry. 2008 Jul 15;47(28):7583-93 PMID: 18558712
  42. Interaction of the yeast Pso5/Rad16 and Sgs1 proteins: influences on DNA repair and aging.
    Mutat Res. 2001 Aug 9;486(3):195-206 PMID: 11459632
  43. The yeast Sgs1 helicase is differentially required for genomic and ribosomal DNA replication.
    EMBO J. 2003 Apr 15;22(8):1939-49 PMID: 12682026
  44. A role for PML and the nuclear body in genomic stability.
    Oncogene. 1999 Dec 23;18(56):7941-7 PMID: 10637504
  45. A hyper-recombination mutation in S. cerevisiae identifies a novel eukaryotic topoisomerase.
    Cell. 1989 Jul 28;58(2):409-19 PMID: 2546682
  46. Structure of the human RECQ1 helicase reveals a putative strand-separation pin.
    Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1039-44 PMID: 19151156
  47. The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins.
    Structure. 1999 Dec 15;7(12):1557-66 PMID: 10647186
  48. The Srs2 helicase prevents recombination by disrupting Rad51 nucleoprotein filaments.
    Nature. 2003 May 15;423(6937):309-12 PMID: 12748645
  49. Systematic mutagenesis of the Saccharomyces cerevisiae MLH1 gene reveals distinct roles for Mlh1p in meiotic crossing over and in vegetative and meiotic mismatch repair.
    Mol Cell Biol. 2003 Feb;23(3):873-86 PMID: 12529393
  50. The full-length Saccharomyces cerevisiae Sgs1 protein is a vigorous DNA helicase that preferentially unwinds holliday junctions.
    J Biol Chem. 2010 Mar 12;285(11):8290-301 PMID: 20086270
  51. Rad51-dependent DNA structures accumulate at damaged replication forks in sgs1 mutants defective in the yeast ortholog of BLM RecQ helicase.
    Genes Dev. 2005 Feb 1;19(3):339-50 PMID: 15687257
  52. DNA polymerase stabilization at stalled replication forks requires Mec1 and the RecQ helicase Sgs1.
    EMBO J. 2003 Aug 15;22(16):4325-36 PMID: 12912929
  53. Mutator phenotype of Werner syndrome is characterized by extensive deletions.
    Proc Natl Acad Sci U S A. 1989 Aug;86(15):5893-7 PMID: 2762303
  54. Supercomplex formation between Mlh1-Mlh3 and Sgs1-Top3 heterocomplexes in meiotic yeast cells.
    Biochem Biophys Res Commun. 2002 Aug 30;296(4):949-53 PMID: 12200140
  55. Cloning and characterization of RECQL, a potential human homologue of the Escherichia coli DNA helicase RecQ.
    J Biol Chem. 1994 Nov 25;269(47):29838-45 PMID: 7961977
  56. The Human RecQ helicases, BLM and RECQ1, display distinct DNA substrate specificities.
    J Biol Chem. 2008 Jun 27;283(26):17766-76 PMID: 18448429
  57. Physical and functional interaction between the Bloom's syndrome gene product and the largest subunit of chromatin assembly factor 1.
    Mol Cell Biol. 2004 Jun;24(11):4710-9 PMID: 15143166
  58. The Bloom's syndrome gene product is homologous to RecQ helicases.
    Cell. 1995 Nov 17;83(4):655-66 PMID: 7585968
  59. Essential role of limiting telomeres in the pathogenesis of Werner syndrome.
    Nat Genet. 2004 Aug;36(8):877-82 PMID: 15235603
  60. Single nucleotide polymorphisms of RecQ1, RAD54L, and ATM genes are associated with reduced survival of pancreatic cancer.
    J Clin Oncol. 2006 Apr 10;24(11):1720-8 PMID: 16520463
  61. Elevated spontaneous mutation rate in SV40-transformed Werner syndrome fibroblast cell lines.
    Somat Cell Mol Genet. 1985 Jul;11(4):303-8 PMID: 2992100
  62. Enhanced tumor formation in mice heterozygous for Blm mutation.
    Science. 2002 Sep 20;297(5589):2051-3 PMID: 12242442
  63. The fission yeast BLM homolog Rqh1 promotes meiotic recombination.
    Genetics. 2008 Jul;179(3):1157-67 PMID: 18562672
  64. Functional role of BLAP75 in BLM-topoisomerase IIIalpha-dependent holliday junction processing.
    J Biol Chem. 2008 Jun 6;283(23):15701-8 PMID: 18390547
  65. Hierarchical deterioration of body systems in Werner's syndrome: implications for normal ageing.
    Mech Ageing Dev. 1997 Dec;98(3):239-54 PMID: 9352493
  66. Molecular defect of RAPADILINO syndrome expands the phenotype spectrum of RECQL diseases.
    Hum Mol Genet. 2003 Nov 1;12(21):2837-44 PMID: 12952869
  67. Replication stress induces sister-chromatid bridging at fragile site loci in mitosis.
    Nat Cell Biol. 2009 Jun;11(6):753-60 PMID: 19465922
  68. Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.
    Science. 2004 Dec 10;306(5703):1951-3 PMID: 15591207
  69. RecQ helicases: multiple structures for multiple functions?
    HFSP J. 2009 Jun;3(3):153-64 PMID: 19949442
  70. Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta.
    Nucleic Acids Res. 2000 Apr 1;28(7):1647-55 PMID: 10710432
  71. Bloom syndrome: a mendelian prototype of somatic mutational disease.
    Medicine (Baltimore). 1993 Nov;72(6):393-406 PMID: 8231788
  72. Sumoylation of RecQ helicase controls the fate of dysfunctional telomeres.
    Mol Cell. 2009 Mar 13;33(5):559-69 PMID: 19285940
  73. Systematic growth studies, cocultivation, and cell hybridization studies of Werner syndrome cultured skin fibroblasts.
    Hum Genet. 1981;58(3):310-6 PMID: 7327553
  74. An abnormal profile of DNA replication intermediates in Bloom's syndrome.
    Cancer Res. 1990 Jun 1;50(11):3141-5 PMID: 2110504
  75. Purification and characterization of the Sgs1 DNA helicase activity of Saccharomyces cerevisiae.
    J Biol Chem. 1998 Apr 17;273(16):9644-50 PMID: 9545297
  76. Molecular genetics of yeast mating type.
    Annu Rev Genet. 1982;16:439-500 PMID: 6760802
  77. Cell cycle regulation of the endogenous wild type Bloom's syndrome DNA helicase.
    Oncogene. 2000 May 25;19(23):2731-8 PMID: 10851073
  78. The jmjN and jmjC domains of the yeast zinc finger protein Gis1 interact with 19 proteins involved in transcription, sumoylation and DNA repair.
    Mol Genet Genomics. 2007 Jan;277(1):57-70 PMID: 17043893
  79. The Sgs1 helicase regulates chromosome synapsis and meiotic crossing over.
    Curr Biol. 2003 Nov 11;13(22):1954-62 PMID: 14614820
  80. DNA helicases Sgs1 and BLM promote DNA double-strand break resection.
    Genes Dev. 2008 Oct 15;22(20):2767-72 PMID: 18923075
  81. DNA helicase Srs2 disrupts the Rad51 presynaptic filament.
    Nature. 2003 May 15;423(6937):305-9 PMID: 12748644
  82. Congenital telangiectatic erythema resembling lupus erythematosus in dwarfs; probably a syndrome entity.
    AMA Am J Dis Child. 1954 Dec;88(6):754-8 PMID: 13206391
  83. Meiotic recombination: too much of a good thing?
    Curr Biol. 2003 Dec 16;13(24):R953-5 PMID: 14680651
  84. Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeast.
    Cell. 2003 Nov 14;115(4):401-11 PMID: 14622595
  85. Mobile D-loops are a preferred substrate for the Bloom's syndrome helicase.
    Nucleic Acids Res. 2006 May 02;34(8):2269-79 PMID: 16670433
  86. Sgs1 function in the repair of DNA replication intermediates is separable from its role in homologous recombinational repair.
    EMBO J. 2009 Apr 8;28(7):915-25 PMID: 19214189
  87. Sterility of Drosophila with mutations in the Bloom syndrome gene--complementation by Ku70.
    Science. 2001 Mar 30;291(5513):2600-2 PMID: 11283371
  88. RecQ family helicases in genome stability: lessons from gene disruption studies in DT40 cells.
    Cell Cycle. 2008 Aug 15;7(16):2472-8 PMID: 18719387
  89. Centromere-proximal crossovers are associated with precocious separation of sister chromatids during meiosis in Saccharomyces cerevisiae.
    Genetics. 2006 Dec;174(4):1745-54 PMID: 17028345
  90. Interaction between yeast sgs1 helicase and DNA topoisomerase III.
    J Biol Chem. 2000 Sep 1;275(35):26898-905 PMID: 10862619
  91. Defective sister-chromatid cohesion, aneuploidy and cancer predisposition in a mouse model of type II Rothmund-Thomson syndrome.
    Hum Mol Genet. 2005 Mar 15;14(6):813-25 PMID: 15703196
  92. The mutation spectrum in RECQL4 diseases.
    Eur J Hum Genet. 2009 Feb;17(2):151-8 PMID: 18716613
  93. Sgs1: a eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation.
    Cell. 1995 Apr 21;81(2):253-60 PMID: 7736577
  94. Escherichia coli RecQ is a rapid, efficient, and monomeric helicase.
    J Biol Chem. 2006 May 5;281(18):12655-63 PMID: 16507576
  95. Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom's syndrome gene.
    Genes Dev. 1998 Nov 1;12(21):3382-93 PMID: 9808625
  96. RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complex.
    EMBO J. 2005 Jun 1;24(11):2024-33 PMID: 15889139
  97. The RecQ gene family in plants.
    J Plant Physiol. 2006 Feb;163(3):287-96 PMID: 16371241
  98. The Escherichia coli RecQ helicase functions as a monomer.
    J Biol Chem. 2003 Sep 12;278(37):34925-33 PMID: 12805371
  99. Sumoylation of the BLM ortholog, Sgs1, promotes telomere-telomere recombination in budding yeast.
    Nucleic Acids Res. 2010 Jan;38(2):488-98 PMID: 19906698
  100. RecQ helicases: multiple roles in genome maintenance.
    Trends Cell Biol. 2003 Sep;13(9):493-501 PMID: 12946629
  101. Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair.
    Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):16906-11 PMID: 18971343
  102. Nucleic acid recognition by OB-fold proteins.
    Annu Rev Biophys Biomol Struct. 2003;32:115-33 PMID: 12598368
  103. The Bloom's syndrome helicase suppresses crossing over during homologous recombination.
    Nature. 2003 Dec 18;426(6968):870-4 PMID: 14685245
  104. The Saccharomyces cerevisiae Sgs1 helicase efficiently unwinds G-G paired DNAs.
    Nucleic Acids Res. 1999 May 1;27(9):1978-84 PMID: 10198430
  105. The processing of Holliday junctions by BLM and WRN helicases is regulated by p53.
    J Biol Chem. 2002 Aug 30;277(35):31980-7 PMID: 12080066
  106. Mus81/Mms4 endonuclease and Sgs1 helicase collaborate to ensure proper recombination intermediate metabolism during meiosis.
    Mol Cell. 2008 Aug 8;31(3):313-23 PMID: 18691964
  107. Multiple pathways regulate 3' overhang generation at S. cerevisiae telomeres.
    Mol Cell. 2009 Jul 10;35(1):70-81 PMID: 19595717
  108. RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments.
    Genes Dev. 2007 Dec 1;21(23):3073-84 PMID: 18003859
  109. BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.
    Genes Dev. 2000 Apr 15;14(8):927-39 PMID: 10783165
  110. G-tail telomere HPA: simple measurement of human single-stranded telomeric overhangs.
    Nat Methods. 2005 Nov;2(11):829-31 PMID: 16278652
  111. The HRDC domain of BLM is required for the dissolution of double Holliday junctions.
    EMBO J. 2005 Jul 20;24(14):2679-87 PMID: 15990871
  112. The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases.
    Nucleic Acids Res. 2001 Jul 1;29(13):2843-9 PMID: 11433031
  113. BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome.
    Genes Dev. 2008 Oct 15;22(20):2856-68 PMID: 18923083
  114. MCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replication.
    EMBO J. 2009 Oct 7;28(19):3005-14 PMID: 19696745
  115. Binding specificity determines polarity of DNA unwinding by the Sgs1 protein of S. cerevisiae.
    J Mol Biol. 1999 Jun 4;289(2):235-48 PMID: 10366502
  116. The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase.
    Mol Cell Biol. 1994 Dec;14(12):8391-8 PMID: 7969174
  117. Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A.
    Nucleic Acids Res. 1998 Jun 15;26(12):2879-85 PMID: 9611231
  118. The Bloom's syndrome gene product interacts with topoisomerase III.
    J Biol Chem. 2000 Mar 31;275(13):9636-44 PMID: 10734115
  119. Chromosomal instability in fibroblasts and mesenchymal tumors from 2 sibs with Rothmund-Thomson syndrome.
    Int J Cancer. 1998 Aug 12;77(4):504-10 PMID: 9679749
  120. Mechanistically distinct roles for Sgs1p in checkpoint activation and replication fork maintenance.
    EMBO J. 2005 Jan 26;24(2):405-17 PMID: 15616582
  121. Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins.
    J Biol Chem. 2002 Jun 14;277(24):22035-44 PMID: 11919194
  122. Positional cloning of the Werner's syndrome gene.
    Science. 1996 Apr 12;272(5259):258-62 PMID: 8602509
  123. Unwinding protein complexes in ALTernative telomere maintenance.
    J Cell Biochem. 2010 Jan 1;109(1):7-15 PMID: 19911388
  124. Oligomeric ring structure of the Bloom's syndrome helicase.
    Curr Biol. 1999 Jun 3;9(11):597-600 PMID: 10359700
  125. Phosphorylation of the Bloom's syndrome helicase and its role in recovery from S-phase arrest.
    Mol Cell Biol. 2004 Feb;24(3):1279-91 PMID: 14729972
  126. Mrc1 and Srs2 are major actors in the regulation of spontaneous crossover.
    EMBO J. 2006 Jun 21;25(12):2837-46 PMID: 16724109
  127. Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends.
    Cell. 2008 Sep 19;134(6):981-94 PMID: 18805091
  128. Intermediates of recombination during mating type switching in Saccharomyces cerevisiae.
    EMBO J. 1990 Mar;9(3):663-73 PMID: 2178924
  129. Purification of two DNA-dependent adenosinetriphosphatases having DNA helicase activity from HeLa cells and comparison of the properties of the two enzymes.
    J Biochem. 1994 Mar;115(3):523-31 PMID: 8056767
  130. BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination.
    EMBO J. 2003 Mar 3;22(5):1210-22 PMID: 12606585
  131. Topoisomerase IIIalpha and Bloom's helicase can resolve a mobile double Holliday junction substrate through convergent branch migration.
    Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11118-23 PMID: 16849422
  132. AtRECQ2, a RecQ helicase homologue from Arabidopsis thaliana, is able to disrupt various recombinogenic DNA structures in vitro.
    Plant J. 2008 Aug;55(3):397-405 PMID: 18419780
  133. Bipartite structure of the SGS1 DNA helicase in Saccharomyces cerevisiae.
    Genetics. 2000 Mar;154(3):1101-14 PMID: 10757756
  134. Cancer predisposition caused by elevated mitotic recombination in Bloom mice.
    Nat Genet. 2000 Dec;26(4):424-9 PMID: 11101838
  135. The Werner syndrome helicase/exonuclease processes mobile D-loops through branch migration and degradation.
    PLoS One. 2009;4(3):e4825 PMID: 19283071
  136. RecQ helicase, in concert with RecA and SSB proteins, initiates and disrupts DNA recombination.
    Genes Dev. 1998 Apr 15;12(8):1134-44 PMID: 9553043
  137. Choreography of recombination proteins during the DNA damage response.
    DNA Repair (Amst). 2009 Sep 2;8(9):1068-76 PMID: 19473884
  138. Partial suppression of the fission yeast rqh1(-) phenotype by expression of a bacterial Holliday junction resolvase.
    EMBO J. 2000 Jun 1;19(11):2751-62 PMID: 10835372
  139. BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates.
    Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4068-73 PMID: 16537486
  140. RecQ helicases: suppressors of tumorigenesis and premature aging.
    Biochem J. 2003 Sep 15;374(Pt 3):577-606 PMID: 12803543
  141. Inhibition of the Bloom's and Werner's syndrome helicases by G-quadruplex interacting ligands.
    Biochemistry. 2001 Dec 18;40(50):15194-202 PMID: 11735402
  142. Mutations in RECQL4 cause a subset of cases of Rothmund-Thomson syndrome.
    Nat Genet. 1999 May;22(1):82-4 PMID: 10319867
  143. Binding and melting of D-loops by the Bloom syndrome helicase.
    Biochemistry. 2000 Nov 28;39(47):14617-25 PMID: 11087418
  144. Yeast Rmi1/Nce4 controls genome stability as a subunit of the Sgs1-Top3 complex.
    Mol Cell Biol. 2005 Jun;25(11):4476-87 PMID: 15899853
  145. G4 DNA unwinding by BLM and Sgs1p: substrate specificity and substrate-specific inhibition.
    Nucleic Acids Res. 2002 Sep 15;30(18):3954-61 PMID: 12235379
  146. Different quaternary structures of human RECQ1 are associated with its dual enzymatic activity.
    PLoS Biol. 2007 Feb;5(2):e20 PMID: 17227144
  147. Expression and nuclear localization of BLM, a chromosome stability protein mutated in Bloom's syndrome, suggest a role in recombination during meiotic prophase.
    J Cell Sci. 2000 Feb;113 ( Pt 4):663-72 PMID: 10652259
  148. The N-terminal region of the Schizosaccharomyces pombe RecQ helicase, Rqh1p, physically interacts with Topoisomerase III and is required for Rqh1p function.
    Mol Genet Genomics. 2005 Mar;273(1):102-14 PMID: 15702347
  149. Growth retardation and skin abnormalities of the Recql4-deficient mouse.
    Hum Mol Genet. 2003 Sep 15;12(18):2293-9 PMID: 12915449
  150. Meiotic chromosome synapsis-promoting proteins antagonize the anti-crossover activity of sgs1.
    PLoS Genet. 2006 Sep 22;2(9):e155 PMID: 17002499
  151. Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing.
    Nature. 2008 Oct 9;455(7214):770-4 PMID: 18806779
  152. SGS1, a homologue of the Bloom's and Werner's syndrome genes, is required for maintenance of genome stability in Saccharomyces cerevisiae.
    Genetics. 1996 Nov;144(3):935-45 PMID: 8913739
  153. Holliday junction processing activity of the BLM-Topo IIIalpha-BLAP75 complex.
    J Biol Chem. 2007 Oct 26;282(43):31484-92 PMID: 17728255
  154. Revisiting the craniosynostosis-radial ray hypoplasia association: Baller-Gerold syndrome caused by mutations in the RECQL4 gene.
    J Med Genet. 2006 Feb;43(2):148-52 PMID: 15964893
  155. Characterization of a highly conserved binding site of Mlh1 required for exonuclease I-dependent mismatch repair.
    Mol Cell Biol. 2009 Feb;29(3):907-18 PMID: 19015241
  156. Mapping the DNA topoisomerase III binding domain of the Sgs1 DNA helicase.
    J Biol Chem. 2001 Mar 23;276(12):8848-55 PMID: 11124263
  157. Saccharomyces cerevisiae Ras/cAMP pathway controls post-diauxic shift element-dependent transcription through the zinc finger protein Gis1.
    EMBO J. 2000 Jun 1;19(11):2569-79 PMID: 10835355
  158. Functional interaction of p53 and BLM DNA helicase in apoptosis.
    J Biol Chem. 2001 Aug 31;276(35):32948-55 PMID: 11399766
  159. Binding and activation of DNA topoisomerase III by the Rmi1 subunit.
    J Biol Chem. 2007 Sep 28;282(39):28971-28979 PMID: 17693398
  160. The Bloom's syndrome gene product promotes branch migration of holliday junctions.
    Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6504-8 PMID: 10823897
  161. Identification of RecQL1 as a Holliday junction processing enzyme in human cell lines.
    Nucleic Acids Res. 2005 Oct 31;33(19):6251-7 PMID: 16260474
Article Info
Journal
Annual review of genetics
Abbr.
Annu Rev Genet
ISSN
1545-2948
DOI
10.1146/annurev-genet-102209-163602
Email
[email protected]
Published
2010-00-00
Pages
393-417
Language
English
Region
United States
NLM ID
0117605
PMCID
PMC4038414
Subset
IM
Grants
NIGMS NIH HHS · R01 GM067055 · United States
NIGMS NIH HHS · R01 GM050237 · United States
NIGMS NIH HHS · GM088413 · United States
NIGMS NIH HHS · GM50237 · United States
NIGMS NIH HHS · F32 GM078840 · United States
NIGMS NIH HHS · R37 GM050237 · United States
NIGMS NIH HHS · K99 GM088413 · United States
NIGMS NIH HHS · R00 GM088413 · United States
NIGMS NIH HHS · GM078840 · United States
External Links
PubMed source DOI: 10.1146/annurev-genet-102209-163602 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2