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PMID: 2165966 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

The NXSM recombinant inbred strains of mice: genetic profile for 58 loci including the Mtv proviral loci.

Genetics ·Vol. 125 ·No. 2 ·1990-06-00 ·Pages 431-46

Eicher EM, Lee BK

Abstract

We report the construction of 17 recombinant inbred (RI) strains of mice derived from the progenitor strains NZB/BINRe and SM/J and the typing of this RI strain set, designated NXSM, for 58 loci distributed on 16 autosomes and the X chromosome. Two backcrosses involving NZB/BINJ and SM/J were constructed to confirm chromosomal assignments and determine gene orders suggested from NXSM RI strain data. From these results we recommend that chromosomal assignments and gene orders suggested from analyses of RI strain sets be confirmed using data obtained by other means. We also typed NZB/BINJ and SM/J for mammary tumor proviral (Mtv) loci. Both strains share three previously described Mtv loci: Mtv-7, Mtv-14 and Mtv-17. In addition, NZB/BINJ contains the previously described Mtv-3 and Mtv-9 loci and two new Mtv proviral loci: Mtv-27 located on chromosome (Chr) 1 and Mtv-28 located on the X chromosome. SM/J contains the previously described loci Mtv-6 and Mtv-8. Four LTR, mink cell focus-forming murine leukemia viral loci were identified and mapped: Ltrm-1 on Chr 12, Ltrm-2 on Chr 16, Ltrm-3 on Chr 5, and Ltrm-4 on Chr 13. The Tgn locus was positioned proximal to the Ly-6 locus on Chr 15.

MeSH Terms
Animals Blotting, Southern Chromosome Mapping Crosses, Genetic DNA Probes Female Genes Genetic Linkage Male Mammary Tumor Virus, Mouse/genetics Mice Mice, Inbred Strains/genetics Mink Cell Focus-Inducing Viruses/genetics Proviruses/genetics Recombination, Genetic Repetitive Sequences, Nucleic Acid
Chemicals
DNA Probes
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Eicher E M
Jackson Laboratory, Bar Harbor, Maine 04609.
Lee B K
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1093/genetics/125.2.431
Published
1990-06-00
Pages
431-46
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1204031
Subset
IM
Grants
NIGMS NIH HHS · GM20919 · United States
NCRR NIH HHS · RR01183 · United States
External Links
PubMed source DOI: 10.1093/genetics/125.2.431 PMC Full Text View journal details
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