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PMID: 22258606 Published · epublish English Journal Article Research Support, Non-U.S. Gov't Review

Inflammasomes in health and disease.

Nature ·Vol. 481 ·No. 7381 ·2012-01-18 ·Pages 278-86

Strowig T, Henao-Mejia J, Elinav E, Flavell R

Abstract

Inflammasomes are a group of protein complexes built around several proteins, including NLRP3, NLRC4, AIM2 and NLRP6. Recognition of a diverse range of microbial, stress and damage signals by inflammasomes results in direct activation of caspase-1, which subsequently induces secretion of potent pro-inflammatory cytokines and a form of cell death called pyroptosis. Inflammasome-mediated processes are important during microbial infections and also in regulating both metabolic processes and mucosal immune responses. We review the functions of the different inflammasome complexes and discuss how aberrations in them are implicated in the pathogenesis of human diseases.

MeSH Terms
Caspase 1/metabolism Disease Health Humans Immunity, Mucosal/immunology Inflammasomes/chemistry,immunology,metabolism Inflammation/immunology,metabolism,pathology Metabolic Syndrome/metabolism,pathology
Chemicals
Inflammasomes Caspase 1
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Strowig Till
Department of Immunobiology, Yale University, Connecticut 06520, USA.
Henao-Mejia Jorge
Elinav Eran
Flavell Richard
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Article Info
Journal
Nature
Abbr.
Nature
ISSN
1476-4687
DOI
10.1038/nature10759
Published
2012-01-18
Epub
2012-00-18
Pages
278-86
Language
English
Region
England
NLM ID
0410462
Subset
IM
Grants
Howard Hughes Medical Institute · United States
External Links
PubMed source DOI: 10.1038/nature10759 View journal details
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