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PMID: 23070366 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Regulation of mammalian cell differentiation by long non-coding RNAs.

EMBO reports ·Vol. 13 ·No. 11 ·2012-11-06 ·Pages 971-83

Hu W, Alvarez-Dominguez JR, Lodish HF

Abstract

Differentiation of specialized cell types from stem and progenitor cells is tightly regulated at several levels, both during development and during somatic tissue homeostasis. Many long non-coding RNAs have been recognized as an additional layer of regulation in the specification of cellular identities; these non-coding species can modulate gene-expression programmes in various biological contexts through diverse mechanisms at the transcriptional, translational or messenger RNA stability levels. Here, we summarize findings that implicate long non-coding RNAs in the control of mammalian cell differentiation. We focus on several representative differentiation systems and discuss how specific long non-coding RNAs contribute to the regulation of mammalian development.

MeSH Terms
Animals Cell Differentiation Embryonic Stem Cells/cytology,metabolism Gene Expression Regulation, Developmental Genes, Homeobox Humans Induced Pluripotent Stem Cells/cytology,metabolism Mammals RNA, Long Noncoding/classification,genetics,metabolism
Chemicals
RNA, Long Noncoding
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Hu Wenqian
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA.
Alvarez-Dominguez Juan R
Lodish Harvey F
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Article Info
Journal
EMBO reports
Abbr.
EMBO Rep
ISSN
1469-3178
DOI
10.1038/embor.2012.145
Published
2012-11-06
Epub
2012-00-16
Pages
971-83
Language
English
Region
England
NLM ID
100963049
PMCID
PMC3492712
Subset
IM
Grants
NHLBI NIH HHS · P01 HL032262 · United States
NIDDK NIH HHS · R01 DK068348 · United States
NIDDK NIH HHS · 2R01 DK0467618 · United States
NHLBI NIH HHS · 2 P01HL032262 · United States
External Links
PubMed source DOI: 10.1038/embor.2012.145 PMC Full Text View journal details
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