Home LiteratureArticle Details
PMID: 23178169 Published · ppublish English Journal Article Research Support, N.I.H., Intramural Review

Posttranscriptional gene regulation by long noncoding RNA.

Journal of molecular biology ·Vol. 425 ·No. 19 ·2013-10-09 ·Pages 3723-30

Yoon JH, Abdelmohsen K, Gorospe M

Abstract

Eukaryotic cells transcribe a vast number of noncoding RNA species. Among them, long noncoding RNAs (lncRNAs) have been widely implicated in the regulation of gene transcription. However, examples of posttranscriptional gene regulation by lncRNAs are emerging. Through extended base-pairing, lncRNAs can stabilize or promote the translation of target mRNAs, while partial base-pairing facilitates mRNA decay or inhibits target mRNA translation. In the absence of complementarity, lncRNAs can suppress precursor mRNA splicing and translation by acting as decoys of RNA-binding proteins or microRNAs and can compete for microRNA-mediated inhibition leading to increased expression of the mRNA. Through these regulatory mechanisms, lncRNAs can elicit differentiation, proliferation, and cytoprotective programs, underscoring the rising recognition of lncRNA roles in human disease. In this review, we summarize the mechanisms of posttranscriptional gene regulation by lncRNAs identified until now.

Keywords
BACE1 PABP RNA-binding protein lincRNA lncRNA long noncoding RNA mRNA turnover poly(A)-binding protein pre-mRNA precursor mRNA small nucleolar lncRNA sno-lncRNA translational regulation β amyloid-cleaving enzyme 1
MeSH Terms
Cell Line, Tumor Humans MicroRNAs/genetics,metabolism RNA Processing, Post-Transcriptional RNA Splicing RNA Stability RNA, Long Noncoding RNA, Messenger/genetics,metabolism RNA-Binding Proteins/genetics,metabolism
Chemicals
MicroRNAs RNA, Long Noncoding RNA, Messenger RNA-Binding Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Yoon Je-Hyun
Laboratory of Genetics, National Institute on Aging-Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA.
Abdelmohsen Kotb
Gorospe Myriam
References (44)
44 references, click to expand
  1. RNA transport and local control of translation.
    Annu Rev Cell Dev Biol. 2005;21:223-45 PMID: 16212494
  2. Long non-coding RNA gadd7 interacts with TDP-43 and regulates Cdk6 mRNA decay.
    EMBO J. 2012 Nov 28;31(23):4415-27 PMID: 23103768
  3. Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase.
    Nat Med. 2008 Jul;14(7):723-30 PMID: 18587408
  4. RNA maps reveal new RNA classes and a possible function for pervasive transcription.
    Science. 2007 Jun 8;316(5830):1484-8 PMID: 17510325
  5. Alternative splicing: new insights from global analyses.
    Cell. 2006 Jul 14;126(1):37-47 PMID: 16839875
  6. Genome-wide analysis of long noncoding RNA stability.
    Genome Res. 2012 May;22(5):885-98 PMID: 22406755
  7. Modular regulatory principles of large non-coding RNAs.
    Nature. 2012 Feb 15;482(7385):339-46 PMID: 22337053
  8. Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat.
    Nature. 2012 Nov 15;491(7424):454-7 PMID: 23064229
  9. LincRNA-p21 suppresses target mRNA translation.
    Mol Cell. 2012 Aug 24;47(4):648-55 PMID: 22841487
  10. The product of the H19 gene may function as an RNA.
    Mol Cell Biol. 1990 Jan;10(1):28-36 PMID: 1688465
  11. Alternative splicing: global insights.
    FEBS J. 2010 Feb;277(4):856-66 PMID: 20082635
  12. Long noncoding RNAs and human disease.
    Trends Cell Biol. 2011 Jun;21(6):354-61 PMID: 21550244
  13. Vernalization-mediated epigenetic silencing by a long intronic noncoding RNA.
    Science. 2011 Jan 7;331(6013):76-9 PMID: 21127216
  14. A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression.
    EMBO J. 2010 Sep 15;29(18):3082-93 PMID: 20729808
  15. A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response.
    Cell. 2010 Aug 6;142(3):409-19 PMID: 20673990
  16. Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay.
    Cell. 2005 Jan 28;120(2):195-208 PMID: 15680326
  17. Malat1 is not an essential component of nuclear speckles in mice.
    RNA. 2012 Aug;18(8):1487-99 PMID: 22718948
  18. Ribosome profiling of mouse embryonic stem cells reveals the complexity and dynamics of mammalian proteomes.
    Cell. 2011 Nov 11;147(4):789-802 PMID: 22056041
  19. Genome-wide maps of chromatin state in pluripotent and lineage-committed cells.
    Nature. 2007 Aug 2;448(7153):553-60 PMID: 17603471
  20. Loss of the abundant nuclear non-coding RNA MALAT1 is compatible with life and development.
    RNA Biol. 2012 Aug;9(8):1076-87 PMID: 22858678
  21. A triple helix stabilizes the 3' ends of long noncoding RNAs that lack poly(A) tails.
    Genes Dev. 2012 Nov 1;26(21):2392-407 PMID: 23073843
  22. Conserved function of lincRNAs in vertebrate embryonic development despite rapid sequence evolution.
    Cell. 2011 Dec 23;147(7):1537-50 PMID: 22196729
  23. A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA.
    Cell. 2011 Oct 14;147(2):358-69 PMID: 22000014
  24. RNA processing and its regulation: global insights into biological networks.
    Nat Rev Genet. 2010 Jan;11(1):75-87 PMID: 20019688
  25. Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs.
    Cell. 2007 Jun 29;129(7):1311-23 PMID: 17604720
  26. Chromatin-associated RNA content of heterochromatin and euchromatin.
    Mol Cell Biochem. 1975 Oct 31;9(1):9-16 PMID: 1186664
  27. Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters.
    Nat Genet. 2011 Jun 05;43(7):621-9 PMID: 21642992
  28. Gene silencing in X-chromosome inactivation: advances in understanding facultative heterochromatin formation.
    Nat Rev Genet. 2011 Jul 18;12(8):542-53 PMID: 21765457
  29. High-resolution profiling of histone methylations in the human genome.
    Cell. 2007 May 18;129(4):823-37 PMID: 17512414
  30. lncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3' UTRs via Alu elements.
    Nature. 2011 Feb 10;470(7333):284-8 PMID: 21307942
  31. Genome regulation by long noncoding RNAs.
    Annu Rev Biochem. 2012;81:145-66 PMID: 22663078
  32. A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?
    Cell. 2011 Aug 5;146(3):353-8 PMID: 21802130
  33. The lncRNA Malat1 is dispensable for mouse development but its transcription plays a cis-regulatory role in the adult.
    Cell Rep. 2012 Jul 26;2(1):111-23 PMID: 22840402
  34. Dendritic BC1 RNA in translational control mechanisms.
    J Cell Biol. 2005 Dec 5;171(5):811-21 PMID: 16330711
  35. Long noncoding RNAs with snoRNA ends.
    Mol Cell. 2012 Oct 26;48(2):219-30 PMID: 22959273
  36. The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r.
    Nat Cell Biol. 2012 Jun 10;14(7):659-65 PMID: 22684254
  37. Long noncoding RNA as modular scaffold of histone modification complexes.
    Science. 2010 Aug 6;329(5992):689-93 PMID: 20616235
  38. Formation of triple-helical structures by the 3'-end sequences of MALAT1 and MENβ noncoding RNAs.
    Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19202-7 PMID: 23129630
  39. Staufen1 regulates diverse classes of mammalian transcripts.
    EMBO J. 2007 Jun 6;26(11):2670-81 PMID: 17510634
  40. The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation.
    Mol Cell. 2010 Sep 24;39(6):925-38 PMID: 20797886
  41. Conservation of a triple-helix-forming RNA stability element in noncoding and genomic RNAs of diverse viruses.
    Cell Rep. 2012 Jul 26;2(1):26-32 PMID: 22840393
  42. Evidence for natural antisense transcript-mediated inhibition of microRNA function.
    Genome Biol. 2010;11(5):R56 PMID: 20507594
  43. A noncoding RNA produced by arthropod-borne flaviviruses inhibits the cellular exoribonuclease XRN1 and alters host mRNA stability.
    RNA. 2012 Nov;18(11):2029-40 PMID: 23006624
  44. The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus.
    Cell. 1992 Oct 30;71(3):515-26 PMID: 1423610
Article Info
Journal
Journal of molecular biology
Abbr.
J Mol Biol
ISSN
1089-8638
DOI
10.1016/j.jmb.2012.11.024
Published
2013-10-09
Epub
2012-00-23
Pages
3723-30
Language
English
Region
England
NLM ID
2985088R
PMCID
PMC3594629
Subset
IM
Grants
Intramural NIH HHS · ZIA AG000511-15 · United States
External Links
PubMed source DOI: 10.1016/j.jmb.2012.11.024 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2