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PMID: 24296535 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Long non-coding RNAs: new players in cell differentiation and development.

Nature reviews. Genetics ·Vol. 15 ·No. 1 ·2014-01-00 ·Pages 7-21

Fatica A, Bozzoni I

Abstract

Genomes of multicellular organisms are characterized by the pervasive expression of different types of non-coding RNAs (ncRNAs). Long ncRNAs (lncRNAs) belong to a novel heterogeneous class of ncRNAs that includes thousands of different species. lncRNAs have crucial roles in gene expression control during both developmental and differentiation processes, and the number of lncRNA species increases in genomes of developmentally complex organisms, which highlights the importance of RNA-based levels of control in the evolution of multicellular organisms. In this Review, we describe the function of lncRNAs in developmental processes, such as in dosage compensation, genomic imprinting, cell differentiation and organogenesis, with a particular emphasis on mammalian development.

MeSH Terms
Animals Cell Differentiation/genetics,physiology Cytoplasm/genetics Dosage Compensation, Genetic/genetics Gene Expression Regulation, Developmental/genetics Genomic Imprinting/genetics Mammals/genetics,growth & development Models, Genetic Models, Molecular Muscles/physiology Organogenesis/genetics RNA, Long Noncoding/genetics Species Specificity
Chemicals
RNA, Long Noncoding
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Fatica Alessandro
Department of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Bozzoni Irene
1] Department of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy. [2] Institute of Molecular Biology and Pathology of the National Research Council, Piazzale Aldo Moro 5, 00185 Rome, Italy. [3] Istituto Pasteur Fondazione Cenci Bolognetti, Piazzale Aldo Moro 5, 00185 Rome, Italy. [4] Center for Life Nano Science @Sapienza, Istituto Italiano di Tecnologia, Sapienza University of Rome, Viale Regina Elena 291, 00161 Rome, Italy.
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Article Info
Journal
Nature reviews. Genetics
Abbr.
Nat Rev Genet
ISSN
1471-0064
DOI
10.1038/nrg3606
Published
2014-01-00
Epub
2013-00-03
Pages
7-21
Language
English
Region
England
NLM ID
100962779
Subset
IM
Grants
Telethon · GGP11149 · Italy
External Links
PubMed source DOI: 10.1038/nrg3606 View journal details
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