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PMID: 2436227 Published · ppublish English Journal Article

Activation of pp60c-src protein kinase activity in human colon carcinoma.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 84 ·No. 8 ·1987-04-00 ·Pages 2251-5

Bolen JB, Veillette A, Schwartz AM, DeSeau V, Rosen N

Abstract

The tyrosine-specific protein kinase activity of pp60c-src molecules obtained from human colon carcinoma tissues and tumor-derived cell lines was found to be elevated over that from normal colon tissues or cultures of normal colon mucosal cells. The elevated pp60c-src protein kinase activity in tumor tissues and in cultured colon carcinoma cells does not appear to result solely from an increase in the abundance of the c-src-encoded protein, suggesting that the specific activity of the pp60c-src tyrosine phosphotransferase is enhanced. These results raise the possibility that activation of the pp60c-src protein kinase may contribute to the genesis of human colon tumors.

MeSH Terms
Cell Line Colon/enzymology Colonic Neoplasms/enzymology Enzyme Activation Humans Intestinal Mucosa/enzymology Protein Kinases/metabolism Proto-Oncogene Proteins/metabolism Proto-Oncogene Proteins pp60(c-src)
Chemicals
Proto-Oncogene Proteins Protein Kinases Proto-Oncogene Proteins pp60(c-src)
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Bolen J B
Veillette A
Schwartz A M
DeSeau V
Rosen N
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41 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.84.8.2251
Published
1987-04-00
Pages
2251-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC304627
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.84.8.2251 PMC Full Text View journal details
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