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PMID: 2463634 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Monoclonal antibodies specific for murine CD2 reveal its presence on B as well as T cells.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 86 ·No. 2 ·1989-01-00 ·Pages 645-9

Yagita H, Nakamura T, Karasuyama H, Okumura K

Abstract

Monoclonal antibodies specific for the murine CD2 antigen were identified by an efficient screening method utilizing murine CD2 cDNA transfectants. An unexpected expression of CD2 on murine B cells was revealed by immunofluorescence and immunoprecipitation studies with these monoclonal antibodies and by RNA blot analysis for the murine CD2 transcript.

MeSH Terms
Animals Antibodies, Monoclonal/immunology Antibody Specificity Antigens, Differentiation, T-Lymphocyte/analysis,genetics Antigens, Surface/analysis,genetics B-Lymphocytes/immunology Blotting, Northern CD2 Antigens Cell Line Cricetinae DNA/genetics Enzyme-Linked Immunosorbent Assay Fibroblasts Fluorescent Antibody Technique Immune Sera/immunology Precipitin Tests RNA/analysis Rats Receptors, Immunologic/analysis,genetics T-Lymphocytes/immunology Transfection
Chemicals
Antibodies, Monoclonal Antigens, Differentiation, T-Lymphocyte Antigens, Surface CD2 Antigens Immune Sera Receptors, Immunologic RNA DNA
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Yagita H
Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan.
Nakamura T
Karasuyama H
Okumura K
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.86.2.645
Published
1989-01-00
Pages
645-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC286529
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.86.2.645 PMC Full Text View journal details
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