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PMID: 25689317 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The Genome 10K Project: a way forward.

Annual review of animal biosciences ·Vol. 3 ·2015-00-00 ·Pages 57-111

Koepfli KP, Paten B, Genome 10K Community of Scientists, O'Brien SJ

Abstract

The Genome 10K Project was established in 2009 by a consortium of biologists and genome scientists determined to facilitate the sequencing and analysis of the complete genomes of 10,000 vertebrate species. Since then the number of selected and initiated species has risen from ∼26 to 277 sequenced or ongoing with funding, an approximately tenfold increase in five years. Here we summarize the advances and commitments that have occurred by mid-2014 and outline the achievements and present challenges of reaching the 10,000-species goal. We summarize the status of known vertebrate genome projects, recommend standards for pronouncing a genome as sequenced or completed, and provide our present and future vision of the landscape of Genome 10K. The endeavor is ambitious, bold, expensive, and uncertain, but together the Genome 10K Consortium of Scientists and the worldwide genomics community are moving toward their goal of delivering to the coming generation the gift of genome empowerment for many vertebrate species.

Keywords
amphibian bird fish genome mammal reptile
MeSH Terms
Animals Computational Biology Forecasting Genome Genomics/methods,trends Humans Species Specificity Vertebrates/genetics
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Koepfli Klaus-Peter
Theodosius Dobzhansky Center for Genome Bioinformatics, St. Petersburg State University, 199034 St. Petersburg, Russian Federation; email: [email protected].
Paten Benedict
Genome 10K Community of Scientists
O'Brien Stephen J
Investigators
45 investigators, click to expand
Koepfli Klaus-Peter
Paten Benedict
Antunes Agostinho
Belov Kathy
Bustamante Carlos
Castoe Todd A
Clawson Hiram
Crawford Andrew J
Diekhans Mark
Distel Dan
Durbin Richard
Earl Dent
Fujita Matthew K
Gamble Tony
Georges Arthur
Gemmell Neil
Gilbert M Thomas P
Graves Jennifer Marshall
Green Richard E
Hickey Glenn
Jarvis Erich D
Johnson Warren
Komissarov Aleksey
Korf Ian
Kuhn Robert
Larkin Denis M
Lewin Harris
Lopez Jose V
Ma Jian
Marques-Bonet Tomas
Miller Webb
Murphy Robert
Pevzner Pavel
Shapiro Beth
Steiner Cynthia
Tamazian Gaik
Venkatesh Byrappa
Wang Jun
Wayne Robert
Wiley Edward
Yang Huanming
Zhang Guojie
Haussler David
Ryder Oliver
O'Brien Stephen J
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Article Info
Journal
Annual review of animal biosciences
Abbr.
Annu Rev Anim Biosci
ISSN
2165-8110
DOI
10.1146/annurev-animal-090414-014900
Email
[email protected]
Published
2015-00-00
Pages
57-111
Language
English
Region
United States
NLM ID
101614024
PMCID
PMC5837290
Subset
IM
Grants
NHGRI NIH HHS · U54 HG007990 · United States
External Links
PubMed source DOI: 10.1146/annurev-animal-090414-014900 PMC Full Text View journal details
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