Home LiteratureArticle Details
PMID: 2878432 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Cognate homeo-box loci mapped on homologous human and mouse chromosomes.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 83 ·No. 23 ·1986-12-00 ·Pages 9104-8

Rabin M, Ferguson-Smith A, Hart CP, Ruddle FH

Abstract

The homeotic genes of Drosophila, which regulate pattern formation during larval development, contain a 180-base-pair DNA sequence termed the "homeo-box." Nucleotide sequence comparisons indicate that the homeo-box motif is highly conserved in a variety of motazoan species. As in Drosophila, homeo-box sequences of mammalian species are expressed in a temporal and tissue-specific pattern during embryogenesis. These observations suggest functional homologies between dipteran and mammalian homeo-box gene products. To identify possible relationships between homeo-box genes of mice and humans, we have compared the chromosomal location of homeo-box genes in these species. Using in situ hybridization and somatic cell genetic techniques, we have mapped the chromosome 6-specific murine Hox-1 homolog to the region p14-p21 on human chromosome 7. We have also regionally mapped the murine Hox-3 locus to 15F1-3 and its human cognate to 12q11-q21. These comparative mapping data indicate that a syntenic relationship in mice and humans is maintained for all homeo-box loci examined to date. We suggest these regions represent evolutionarily conserved genomic domains encoding homologous protein products that function in regulating patterns of mammalian development.

MeSH Terms
Animals Biological Evolution Chromosome Mapping Chromosomes, Human, Pair 12 Chromosomes, Human, Pair 7 Genes, Homeobox Humans Mice Multigene Family
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Rabin M
Ferguson-Smith A
Hart C P
Ruddle F H
References (48)
48 references, click to expand
  1. A system of nomenclature for band patterns of mouse chromosomes.
    Chromosoma. 1973;41(2):145-58 PMID: 4120886
  2. Homeo box gene complex on mouse chromosome 11: molecular cloning, expression in embryogenesis, and homology to a human homeo box locus.
    Cell. 1985 Nov;43(1):9-18 PMID: 3000607
  3. Selective induction of murine oncornavirus gene expression in somatic cell hybrids between mouse peritoneal macrophages and SV-40-transformed human cells.
    Virology. 1976 Apr;70(2):545-9 PMID: 178099
  4. Genetics of the connective tissue proteins: assignment of the gene for human type I procollagen to chromosome 17 by analysis of cell hybrids and microcell hybrids.
    Proc Natl Acad Sci U S A. 1977 Oct;74(10):4444-8 PMID: 412188
  5. Assignment of a type I collagen structural gene to human chromosome 7.
    Nature. 1978 Apr 6;272(5653):548-9 PMID: 692662
  6. Late replication in an X-autosome translocation in the mouse: correlation with genetic inactivation and evidence for selective effects during embryogenesis.
    Proc Natl Acad Sci U S A. 1979 Oct;76(10):5234-8 PMID: 291940
  7. Human type I procollagen genes are located on different chromosomes.
    Proc Natl Acad Sci U S A. 1982 Nov;79(21):6627-30 PMID: 6292910
  8. Mapping of the human gene for epidermal growth factor receptor (EGFR) on the p13 leads to q22 region of chromosome 7.
    Cytogenet Cell Genet. 1983;35(1):9-14 PMID: 6297856
  9. Localization of the human 2(I) collagen gene (COL1A2) to chromosome 7q22.
    Cytogenet Cell Genet. 1983;36(3):586-7 PMID: 6641290
  10. NRAS transforming gene maps to region p11----p13 on chromosome 1 by in situ hybridization.
    Cytogenet Cell Genet. 1984;38(1):70-2 PMID: 6705568
  11. Chromosomal localisation of the human homologues to the oncogenes erbA and B.
    EMBO J. 1984 Jan;3(1):159-63 PMID: 6323162
  12. Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells.
    Science. 1984 Apr 27;224(4647):417-9 PMID: 6200934
  13. Expression cloning of human EGF receptor complementary DNA: gene amplification and three related messenger RNA products in A431 cells.
    Science. 1984 May 25;224(4651):843-8 PMID: 6326261
  14. A homologous protein-coding sequence in Drosophila homeotic genes and its conservation in other metazoans.
    Cell. 1984 Jun;37(2):403-8 PMID: 6327065
  15. Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells.
    Nature. 1984 May 31-Jun 6;309(5967):418-25 PMID: 6328312
  16. The T cell receptor beta chain genes are located on chromosome 6 in mice and chromosome 7 in humans.
    Cell. 1984 Jul;37(3):1091-9 PMID: 6331676
  17. Cellular homologs of the avian erythroblastosis virus erb-A and erb-B genes are syntenic in mouse but asyntenic in man.
    Proc Natl Acad Sci U S A. 1984 Aug;81(15):4874-8 PMID: 6087351
  18. Chromosomal assignments of human genes for serine proteases trypsin, chymotrypsin B, and elastase.
    Somat Cell Mol Genet. 1984 Jul;10(4):369-76 PMID: 6589790
  19. Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse.
    Somat Cell Mol Genet. 1984 Jul;10(4):377-83 PMID: 6589791
  20. Chromosomal location of human T-cell receptor gene Ti beta.
    Science. 1984 Oct 19;226(4672):348-9 PMID: 6435246
  21. Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila.
    Cell. 1984 Oct;38(3):667-73 PMID: 6091895
  22. Molecular cloning and chromosome mapping of a mouse DNA sequence homologous to homeotic genes of Drosophila.
    Cell. 1984 Oct;38(3):675-80 PMID: 6091896
  23. A human T-cell antigen receptor beta chain gene maps to chromosome 7.
    EMBO J. 1984 Oct;3(10):2347-9 PMID: 6548704
  24. DNA sequence amplification in mammalian cells.
    Int Rev Cytol. 1984;90:31-82 PMID: 6389416
  25. Molecular cloning and chromosomal assignment of the human homolog of int-1, a mouse gene implicated in mammary tumorigenesis.
    Mol Cell Biol. 1984 Nov;4(11):2532-4 PMID: 6513929
  26. Comparative chromosome mapping of a conserved homoeo box region in mouse and human.
    Nature. 1985 Mar 14-20;314(6007):173-5 PMID: 3919316
  27. Two homoeo box loci mapped in evolutionarily related mouse and human chromosomes.
    Nature. 1985 Mar 14-20;314(6007):175-8 PMID: 4038785
  28. Location of gene for beta subunit of human T-cell receptor at band 7q35, a region prone to rearrangements in T cells.
    Science. 1985 May 3;228(4699):580-2 PMID: 3983641
  29. Genes for beta chain of human T-cell antigen receptor map to regions of chromosomal rearrangement in T cells.
    Science. 1985 May 3;228(4699):582-5 PMID: 3983642
  30. Assignment of the gene for carboxypeptidase A to human chromosome 7q22----qter and to mouse chromosome 6.
    Hum Genet. 1986 Jan;72(1):27-31 PMID: 3455919
  31. Genes encoding pancreatic polypeptide and neuropeptide Y are on human chromosomes 17 and 7.
    J Clin Invest. 1986 Mar;77(3):1038-41 PMID: 3753985
  32. Mammalian homeo box genes.
    Cold Spring Harb Symp Quant Biol. 1985;50:277-84 PMID: 2420513
  33. Spatial restriction in expression of a mouse homoeo box locus within the central nervous system.
    Nature. 1986 Mar 27-Apr 2;320(6060):328-35 PMID: 3007994
  34. A human homoeo box gene specifically expressed in spinal cord during embryonic development.
    Nature. 1986 Apr 24-30;320(6064):763-5 PMID: 3453105
  35. A mouse homeo box gene is expressed in spermatocytes and embryos.
    Science. 1986 Aug 8;233(4764):663-7 PMID: 3726554
  36. Localization of a novel v-erbB-related gene, c-erbB-2, on human chromosome 17 and its amplification in a gastric cancer cell line.
    Mol Cell Biol. 1986 Mar;6(3):955-8 PMID: 2430175
  37. The human type II collagen gene (COL2A1) assigned to 12q14.3.
    Ann Hum Genet. 1986 May;50(Pt 2):131-7 PMID: 3435042
  38. Regional chromosome mapping of human collagen genes alpha 2(I) and alpha 1(I) (COLIA2 and COLIA1).
    Hum Genet. 1985;69(4):304-8 PMID: 3857213
  39. Chromosomal localization of the human T cell receptor beta-chain genes.
    Cell. 1985 May;41(1):335 PMID: 3995587
  40. Chromosomal assignments of the genes coding for human types II, III, and IV collagen: a dispersed gene family.
    Proc Natl Acad Sci U S A. 1985 May;82(10):3330-4 PMID: 2987919
  41. Homoeotic transformations in man: implications for the mechanism of embryonic development and for the organization of epithelia.
    J Theor Biol. 1985 Jun 7;114(3):463-90 PMID: 3927066
  42. A mouse homoeo box gene is expressed during embryogenesis and in adult kidney.
    Nature. 1985 Oct 24-30;317(6039):745-8 PMID: 4058581
  43. Report of the Committee on Comparative Mapping.
    Cytogenet Cell Genet. 1985;40(1-4):536-66 PMID: 3933918
  44. Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene.
    Science. 1985 Dec 6;230(4730):1132-9 PMID: 2999974
  45. Expression of homologous homeo-box-containing genes in differentiated human teratocarcinoma cells and mouse embryos.
    Cell. 1985 Nov;43(1):19-28 PMID: 4075393
  46. Expression during embryogenesis of a mouse gene with sequence homology to the Drosophila engrailed gene.
    Cell. 1985 Nov;43(1):29-37 PMID: 2416459
  47. Clustered homeo boxes are differentially expressed during murine development.
    Cell. 1985 Nov;43(1):39-45 PMID: 2416462
  48. Detection of specific sequences among DNA fragments separated by gel electrophoresis.
    J Mol Biol. 1975 Nov 5;98(3):503-17 PMID: 1195397
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.83.23.9104
Published
1986-12-00
Pages
9104-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC387083
Subset
IM
Grants
NIGMS NIH HHS · GM09966 · United States
External Links
PubMed source DOI: 10.1073/pnas.83.23.9104 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2