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PMID: 29545546 Published · ppublish English Journal Article Review

Dendritic structural plasticity and neuropsychiatric disease.

Nature reviews. Neuroscience ·Vol. 19 ·No. 4 ·2018-00-16 ·Pages 215-234

Forrest MP, Parnell E, Penzes P

Abstract

The structure of neuronal circuits that subserve cognitive functions in the brain is shaped and refined throughout development and into adulthood. Evidence from human and animal studies suggests that the cellular and synaptic substrates of these circuits are atypical in neuropsychiatric disorders, indicating that altered structural plasticity may be an important part of the disease biology. Advances in genetics have redefined our understanding of neuropsychiatric disorders and have revealed a spectrum of risk factors that impact pathways known to influence structural plasticity. In this Review, we discuss the importance of recent genetic findings on the different mechanisms of structural plasticity and propose that these converge on shared pathways that can be targeted with novel therapeutics.

MeSH Terms
Animals Brain/physiopathology Dendrites/genetics,physiology Genetic Predisposition to Disease Humans Mental Disorders/genetics,physiopathology Nerve Tissue Proteins/genetics Neuronal Plasticity/genetics Risk Factors
Chemicals
Nerve Tissue Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Forrest Marc P
Department of Physiology, Northwestern University, Chicago, IL, USA.
Parnell Euan
Department of Physiology, Northwestern University, Chicago, IL, USA.
Penzes Peter
Department of Physiology, Northwestern University, Chicago, IL, USA. | Northwestern University Center for Autism and Neurodevelopment, Feinberg School of Medicine, Chicago, IL, USA.
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Article Info
Journal
Nature reviews. Neuroscience
Abbr.
Nat Rev Neurosci
ISSN
1471-0048
DOI
10.1038/nrn.2018.16
Published
2018-00-16
Pages
215-234
Language
English
Region
England
NLM ID
100962781
PMCID
PMC6442683
Grants
NIMH NIH HHS · R01 MH071316 · United States
NIMH NIH HHS · R01 MH097216 · United States
NIMH NIH HHS · R01 MH107182 · United States
NINDS NIH HHS · R01 NS100785 · United States
External Links
PubMed source DOI: 10.1038/nrn.2018.16 PMC Full Text View journal details
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