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PMID: 2983106 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Characterization of an endogenous retrovirus-repetitive DNA chimera in the mouse genome.

Journal of virology ·Vol. 53 ·No. 3 ·1985-03-00 ·Pages 998-1000

Fanning TG, Morris DW, Cardiff RD, Bradshaw HD

Abstract

We found that an endogenous mouse mammary tumor provirus, GR-MTV-8, is embedded within a member of the BAM HI family of long interspersed repetitive mouse DNAs. GR-MTV-8 appears to be transcriptionally silent at its normal chromosomal position in the mouse genome. The provirus is transcriptionally active, however, when cloned and transfected into mouse cells (Kennedy et al., Nature (London) 295:622-624, 1982). We propose that the transcriptional inactivity of GR-MTV-8 in situ is due to an inhibitory effect, possibly involving DNA methylation, attributable to the flanking BAM HI element.

MeSH Terms
Animals Base Sequence Chimera DNA, Viral/analysis,metabolism Mammary Tumor Virus, Mouse/genetics Methylation Mice Transcription, Genetic
Chemicals
DNA, Viral
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Fanning T G
Morris D W
Cardiff R D
Bradshaw H D
References (36)
36 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.53.3.998-1000.1985
Published
1985-03-00
Pages
998-1000
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC254742
Subset
IM
Grants
NCI NIH HHS · 1R01 CA 31702-01 · United States
NCI NIH HHS · 5R01CA21454 · United States
External Links
PubMed source DOI: 10.1128/JVI.53.3.998-1000.1985 PMC Full Text View journal details
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