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PMID: 304674 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

A morphologic and immunologic surface marker study of 299 cases of non-Hodgkin lymphomas and related leukemias.

The American journal of pathology ·Vol. 90 ·No. 2 ·1978-02-00 ·Pages 461-86

Lukes RJ, Taylor CR, Parker JW, Lincoln TL, Pattengale PK, Tindle BH

Abstract

This study relateds the cytologic types of the classification of malignant lymphoma of Lukes and Collins to the results of immunologic surface marker studies as part of a systematic multiparameter study of 299 cases of non-Hodgkin lymphomas. The results support the hypothesis that malignant lymphomas are neoplasms of the immune system and involve the B- and T-cell systems and, rarely, histiocytes. The morphologic features of the cytologic types of Lukes and Collins are predictive of the subtypes of lymphoma and considerably more effective than the immunologic surface marker techniques in identifying homogeneous groups. There are considerable methodologic and interpretive problems that are evaluated in detail. The verification of the B- and T-cell subtypes of the Lukes and Collins classification indicates that the time has come to change from the terminology and classification of lymphomas of the past to a modern immunologic approach.

MeSH Terms
B-Lymphocytes/immunology Cell Separation Child Complement C3/analysis Complement System Proteins Histiocytes/immunology Humans Immunoglobulin Fc Fragments/analysis Leukemia/classification,immunology Lymphocyte Activation Lymphoma/classification,immunology Methods Receptors, Antigen, B-Cell/analysis Rosette Formation T-Lymphocytes/immunology
Chemicals
Complement C3 Immunoglobulin Fc Fragments Receptors, Antigen, B-Cell Complement System Proteins
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Lukes R J
Taylor C R
Parker J W
Lincoln T L
Pattengale P K
Tindle B H
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1978-02-00
Pages
461-86
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC2018138
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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