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PMID: 30617162 Published · epublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Understanding phosphoinositides: rare, dynamic, and essential membrane phospholipids.

The Biochemical journal ·Vol. 476 ·No. 1 ·2019-00-07 ·Pages 1-23

Dickson EJ, Hille B

Abstract

Polyphosphoinositides (PPIs) are essential phospholipids located in the cytoplasmic leaflet of eukaryotic cell membranes. Despite contributing only a small fraction to the bulk of cellular phospholipids, they make remarkable contributions to practically all aspects of a cell's life and death. They do so by recruiting cytoplasmic proteins/effectors or by interacting with cytoplasmic domains of membrane proteins at the membrane-cytoplasm interface to organize and mold organelle identity. The present study summarizes aspects of our current understanding concerning the metabolism, manipulation, measurement, and intimate roles these lipids play in regulating membrane homeostasis and vital cell signaling reactions in health and disease.

Keywords
PTEN lipid transfer phosphatidylinositol phosphoinositide 3-kinase transmembrane proteins
MeSH Terms
Animals Cell Membrane/metabolism Humans Membrane Proteins/metabolism Phosphatidylinositols/metabolism Signal Transduction
Chemicals
Membrane Proteins Phosphatidylinositols
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Dickson Eamonn J ORCID
Department of Physiology and Membrane Biology, University of California Davis, Davis, CA 95616, U.S.A. [email protected].
Hille Bertil ORCID
Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, WA 98195, U.S.A.
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
1470-8728
DOI
10.1042/BCJ20180022
Email
[email protected]
Published
2019-00-07
Epub
2019-00-07
Pages
1-23
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC6342281
Subset
IM
Grants
NIGMS NIH HHS · R01 GM127513 · United States
NINDS NIH HHS · R37 NS008174 · United States
External Links
PubMed source DOI: 10.1042/BCJ20180022 PMC Full Text View journal details
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