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PMID: 3279393 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Sigma elements are position-specific for many different yeast tRNA genes.

Nucleic acids research ·Vol. 16 ·No. 4 ·1988-02-25 ·Pages 1499-515

Sandmeyer SB, Bilanchone VW, Clark DJ, Morcos P, Carle GF, Brodeur GM

Abstract

We determined the DNA sequence of seventeen sigma elements and flanking regions in order to investigate the extent of the association between the yeast repetitive element, sigma, and tRNA genes. Fifteen of seventeen sigma elements analyzed begin at position -19 to -16 with respect to the 5' end of a tRNA-coding sequence. This region is close to the initiation point of tRNA gene transcription and contains a sequence which is modestly conserved for a number of tRNA genes. Two pairs of identical sigma elements occur as the long terminal repeats of a sequence which, together with flanking sigma elements, has the structural properties of a retrotransposon; this element has been named Ty3 (manuscript submitted). Hybridization analysis of yeast chromosomal DNA separated by orthogonal field alternation gel electrophoresis (OFAGE) showed that Ty3 and isolated sigma elements are distributed over many chromosomes in the yeast genome.

MeSH Terms
Base Sequence Chromosome Mapping Cloning, Molecular Genes, Fungal Molecular Sequence Data RNA, Transfer/genetics Saccharomyces cerevisiae/genetics Sigma Factor/genetics Transcription Factors/genetics
Chemicals
Sigma Factor Transcription Factors RNA, Transfer
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Sandmeyer S B
Department of Microbiology and Molecular Genetics, California College of Medicine, University of California, Irvine 92717.
Bilanchone V W
Clark D J
Morcos P
Carle G F
Brodeur G M
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/16.4.1499
Published
1988-02-25
Pages
1499-515
Language
English
Region
England
NLM ID
0411011
PMCID
PMC336330
Subset
IM
Grants
NIGMS NIH HHS · GM33281 · United States
Databases
GENBANK
X07086, X07087, X07088, X07089, X07090
External Links
PubMed source DOI: 10.1093/nar/16.4.1499 PMC Full Text View journal details
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