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PMID: 3862930 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Methylation of 16S ribosomal RNA and resistance to aminoglycoside antibiotics in clones of Streptomyces lividans carrying DNA from Streptomyces tenjimariensis.

Molecular & general genetics : MGG ·Vol. 200 ·No. 3 ·1985-00-00 ·Pages 415-21

Skeggs PA, Thompson J, Cundliffe E

Abstract

A single gene from Streptomyces tenjimariensis, conferring resistance to kanamycin, apramycin and sisomicin, has been cloned in Streptomyces lividans. The mechanism of resistance involves methylation of 16S RNA in the 30S ribosomal subunit.

MeSH Terms
Aminoglycosides/pharmacology Anti-Bacterial Agents/pharmacology Cloning, Molecular DNA, Bacterial/genetics Drug Resistance, Microbial Genes, Bacterial Methylation Protein Biosynthesis/drug effects RNA, Ribosomal/genetics Species Specificity Streptococcus/drug effects,genetics Structure-Activity Relationship
Chemicals
Aminoglycosides Anti-Bacterial Agents DNA, Bacterial RNA, Ribosomal
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Skeggs P A
Thompson J
Cundliffe E
References (36)
36 references, click to expand
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Article Info
Journal
Molecular & general genetics : MGG
Abbr.
Mol Gen Genet
ISSN
0026-8925
DOI
10.1007/BF00425725
Published
1985-00-00
Pages
415-21
Language
English
Region
Germany
NLM ID
0125036
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00425725
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