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PMID: 4000927 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

An H1 histone gene-specific 5' element and evolution of H1 and H5 genes.

Nucleic acids research ·Vol. 13 ·No. 2 ·1985-01-25 ·Pages 585-94

Coles LS, Wells JR

Abstract

In previous studies we have shown that the H5 gene is not closely linked to the dispersed clusters of core and H1 histone genes. Here we emphasise features of H1 and H5 genes relevant to their expression in the chicken genome. Of particular note is an H1 gene-specific 5' element, 5' AAACACA 3' found upstream of all H1 genes studied to date. This "H1-box" is not found in the related H5 gene, which is expressed only in erythroid cells. A second aspect relates to generation of histone mRNA 3' termini. The H5 gene is shown to contain a remnant of the dyad symmetry element (as well as other conserved sequences) associated with core and H1-histone gene transcript 3' processing. However, it appears as if H5 has evolved a different mechanism in which the mRNA terminus (which is polyadenylated) is displaced downstream from the dyad element. The two clear differences noted here have the potential to affect transcriptional (H1-box) and post-transcriptional (3' terminus processing) regulation of H1 and H5 gene expression.

MeSH Terms
Animals Base Sequence Biological Evolution Chickens/genetics Genes Histones/genetics Promoter Regions, Genetic RNA Processing, Post-Transcriptional RNA, Messenger/genetics
Chemicals
Histones RNA, Messenger
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Coles L S
Wells J R
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26 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/13.2.585
Published
1985-01-25
Pages
585-94
Language
English
Region
England
NLM ID
0411011
PMCID
PMC341016
Subset
IM
Databases
GENBANK
X01752
External Links
PubMed source DOI: 10.1093/nar/13.2.585 PMC Full Text View journal details
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