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PMID: 4080545 Published · ppublish English Journal Article

Alu sequences transcription in X. laevis oocytes: nuclear-cytoplasmic partitioning and evidence for 3' end processing reactions.

Nucleic acids research ·Vol. 13 ·No. 23 ·1985-12-09 ·Pages 8359-77

Perlino E, Paonessa G, Ciliberto G

Abstract

A large Alu-family cluster in the 5' flanking region of a human alpha 1-acid glycoprotein gene has been identified and sequenced. Individual members microinjected into X. laevis oocytes are transcribed only when canonical box A and B components of the split pol III promoter are present. Alu transcripts accumulate in the nucleus. An unusually short Alu transcript, able to assume a stable secondary structure, undergoes a 3' end processing reaction similar to the one required for tRNA 3' end maturation.

MeSH Terms
Animals Base Sequence Cell Compartmentation Cell Nucleus/physiology Cytoplasm/physiology Genetic Linkage Humans Nucleic Acid Conformation Orosomucoid/genetics RNA Processing, Post-Transcriptional Repetitive Sequences, Nucleic Acid Transcription, Genetic Xenopus laevis/genetics
Chemicals
Orosomucoid
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Perlino E
Paonessa G
Ciliberto G
References (28)
28 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/13.23.8359
Published
1985-12-09
Pages
8359-77
Language
English
Region
England
NLM ID
0411011
PMCID
PMC322139
Subset
IM
Databases
GENBANK
X03273
External Links
PubMed source DOI: 10.1093/nar/13.23.8359 PMC Full Text View journal details
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