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PMID: 6092260 Published · ppublish English Journal Article

Genetic changes in mammalian cells reminiscent of an SOS response.

Human genetics ·Vol. 67 ·No. 4 ·1984-00-00 ·Pages 360-8

Herrlich P, Mallick U, Ponta H, Rahmsdorf HJ

Abstract

Prior to the isolation of mammalian DNA repair genes and identification of their gene products, the comparison between the bacterial SOS response and various similar reactions in mammalian cells remains rather speculative. The increasing number of observed phenomena including enhanced DNA repair, virus induction, induced cellular differentiation, and neoplastic transformation, all following DNA damage or arrest of replication, are, however, suggestive of an SOS-like system of growth control and may form an entry into this fascinating area.

MeSH Terms
Animals Cell Differentiation Cell Line Cell Survival Cell Transformation, Neoplastic DNA/genetics DNA Repair DNA Replication DNA, Bacterial/genetics Escherichia coli/genetics Gene Amplification Gene Expression Regulation Genes Genes, Bacterial Humans Mammary Tumor Virus, Mouse/growth & development Mutation Phenotype Simian virus 40/growth & development Virus Activation
Chemicals
DNA, Bacterial DNA
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Herrlich P
Mallick U
Ponta H
Rahmsdorf H J
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Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00291392
Published
1984-00-00
Pages
360-8
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00291392 View journal details
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