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PMID: 6130844 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Comparative aspects of opioid-dopamine interaction.

Cellular and molecular neurobiology ·Vol. 2 ·No. 3 ·1982-09-00 ·Pages 167-78

Stefano GB

Abstract

1. Opiate receptors are found in invertebrate as well as mammalian systems, often in proximity to dopamergic systems. This review summarizes the interrelationships between these two transmitter systems in invertebrates. 2. The comparative data discussed here are of considerable significance. They recall that the opioid-dopamine relationships first demonstrated in the mammalian nervous system also apply to invertebrates and are therefore of more general importance. The results obtained in the mollusk Mytilus strengthen the concept that the activity of dopaminergic neurons may be modulated by afferent opioid signals and that, even in "more primitive" animals, interneuronal transfer of information is more complex than formerly visualized. Furthermore, the data indicate that endogenous opioids may exert tonic control over dopamine metabolism, thus implying interdependence of the two systems.

MeSH Terms
Aging Animals Behavior Cyclic AMP/metabolism Dopamine/metabolism,physiology Humans Neurons/physiology Neurotransmitter Agents/physiology Norepinephrine/physiology Receptors, Opioid/metabolism,physiology Species Specificity
Chemicals
Neurotransmitter Agents Receptors, Opioid Cyclic AMP Dopamine Norepinephrine
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Stefano G B
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Article Info
Journal
Cellular and molecular neurobiology
Abbr.
Cell Mol Neurobiol
ISSN
0272-4340
DOI
10.1007/BF00711145
Published
1982-09-00
Pages
167-78
Language
English
Region
United States
NLM ID
8200709
Subset
IM
Grants
NCRR NIH HHS · RR-08180 · United States
External Links
PubMed source DOI: 10.1007/BF00711145 View journal details
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