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PMID: 6318040 Published · ppublish English Journal Article

Regulatory interactions among the cya, crp and pts gene products in Salmonella typhimurium.

Molecular & general genetics : MGG ·Vol. 192 ·No. 3 ·1983-00-00 ·Pages 477-86

Dobrogosz WJ, Hall GW, Sherba DK, Silva DO, Harman JG, Melton T

Abstract

A well-characterized set of pts deletion mutants of Salmonella typhimurium were used to re-evaluate the purported role of the PTS in the inducer exclusion process and in regulation cAMP synthesis. During the course of these studies a class of secondary mutations was isolated which suppress the inhibition of cAMP synthesis caused by pts mutations. These suppressor mutations were traced to the crp locus and tentatively designated as acr (adenylate cyclase regulation) mutations. A new model is proposed in which CRP rather than adenylate cyclase is believed to be the central regulatory element in the catabolite repression phenomenon.

MeSH Terms
Cyclic AMP/biosynthesis Gene Expression Regulation Genes, Bacterial Models, Genetic Mutation Salmonella typhimurium/genetics Suppression, Genetic
Chemicals
Cyclic AMP
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Dobrogosz W J
Hall G W
Sherba D K
Silva D O
Harman J G
Melton T
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47 references, click to expand
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Article Info
Journal
Molecular & general genetics : MGG
Abbr.
Mol Gen Genet
ISSN
0026-8925
DOI
10.1007/BF00392194
Published
1983-00-00
Pages
477-86
Language
English
Region
Germany
NLM ID
0125036
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00392194
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