Home LiteratureArticle Details
PMID: 6578701 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Occurrence and expression of imipemide (N-formimidoyl thienamycin) resistance in clinical isolates of coagulase-negative staphylococci.

Antimicrobial agents and chemotherapy ·Vol. 24 ·No. 1 ·1983-07-00 ·Pages 61-9

Blumenthal RM, Raeder R, Takemoto CD, Freimer EH

Abstract

More than 500 clinical isolates were screened for resistance to a number of antibiotics, including imipemide (N-formimidoyl thienamycin [MK0787]). Of the 25 coagulase-negative staphylococcal isolates present in the screening sample, almost one-third showed one of two patterns of imipemide resistance. One pattern apparently involves constitutive expression of drug resistance, whereas the other pattern seems to result from an inducible resistance having an apparent induction threshold higher than the minimal inhibitory concentration of imipemide. The mechanism(s) responsible for this imipemide resistance is unclear, but may be distinct from the more common staphylococcal mechanisms of resistance to beta-lactam antibiotics. Only two of the patients from whom imipemide-resistant staphylococci were cultured had actually been treated with the antibiotic.

MeSH Terms
Coagulase/metabolism Drug Resistance, Microbial Imipenem Microbial Sensitivity Tests Phenotype Staphylococcus/drug effects,enzymology Thienamycins/pharmacology Time Factors
Chemicals
Coagulase Thienamycins Imipenem
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Blumenthal R M
Raeder R
Takemoto C D
Freimer E H
References (30)
30 references, click to expand
  1. Aminoglycoside-modifying enzyme of an antibiotic-producing bacterium acts as a determinant of antibiotic resistance in Escherichia coli.
    Proc Natl Acad Sci U S A. 1977 Mar;74(3):999-1003 PMID: 322154
  2. Transduction of Methicillin Resistance in Staphylococcus aureus Dependent on an Unusual Specificity of the Recipient Strain.
    J Bacteriol. 1970 Dec;104(3):1158-67 PMID: 16559089
  3. Plasmid-mediated penicillin beta-lactamases in Pseudomonas aeruginosa.
    Antimicrob Agents Chemother. 1976 Jan;9(1):55-60 PMID: 4010
  4. A new type of penicillin resistance of Staphylococcus aureus.
    Lancet. 1977 Feb 26;1(8009):443-7 PMID: 65561
  5. Further observations on the zone phenomenon in the bactericidal action of penicillin.
    J Bacteriol. 1951 Nov;62(5):663-8 PMID: 14897844
  6. How do antibiotic-producing microorganisms avoid suicide?
    Ann N Y Acad Sci. 1974 May 10;235(0):601-12 PMID: 4604540
  7. Antibiotic susceptibility testing by a standardized single disk method.
    Am J Clin Pathol. 1966 Apr;45(4):493-6 PMID: 5325707
  8. In vitro activity of N-formimidoyl thienamycin (MK0787) against resistant strains of Pseudomonas aeruginosa, Staphylococcus epidermidis, Serratia marcescens, and Enterococcus spp.
    Antimicrob Agents Chemother. 1981 Jan;19(1):114-6 PMID: 6787975
  9. Replication and expression of plasmids from Staphylococcus aureus in Bacillus subtilis.
    Proc Natl Acad Sci U S A. 1977 Apr;74(4):1680-2 PMID: 404641
  10. Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria.
    Proc Natl Acad Sci U S A. 1973 Aug;70(8):2276-80 PMID: 4209515
  11. Staphylococcal plasmids that replicate and express erythromycin resistance in both Streptococcus pneumoniae and Escherichia coli.
    Proc Natl Acad Sci U S A. 1982 May;79(9):2991-5 PMID: 6283551
  12. Purification and properties of inducible penicillin beta-lactamase isolated from Pseudomonas maltophilia.
    Antimicrob Agents Chemother. 1982 Oct;22(4):564-70 PMID: 6983856
  13. Origin and function of penicillinase: a problem in biochemical evolution.
    Br Med J. 1967 Oct 14;4(5571):71-7 PMID: 4963324
  14. In vitro comparison of N-formimidoyl thienamycin, piperacillin, cefotaxime, and cefoperazone.
    Antimicrob Agents Chemother. 1981 Jul;20(1):140-3 PMID: 6269481
  15. Effect of N-formimidoyl thienamycin (MK0787) on beta-lactamases and activity against beta-lactamase-producing strains.
    Antimicrob Agents Chemother. 1980 Nov;18(5):837-8 PMID: 6969580
  16. Transduction of methicillin resistance in Staphylococcus aureus: recipient effectiveness and beta-lactamase production.
    Antimicrob Agents Chemother. 1980 Sep;18(3):424-32 PMID: 6448580
  17. Comparative in vitro activity of N-formimidoyl thienamycin against gram-positive and gram-negative aerobic and anaerobic species and its beta-lactamase stability.
    Antimicrob Agents Chemother. 1982 Jan;21(1):180-7 PMID: 6979306
  18. Naturally occurring constitutive -lactamase of novel serotype in Staphylococcus aureus.
    J Gen Microbiol. 1973 Jul;77(1):229-31 PMID: 4723942
  19. Antibiotic resistance in pathogenic and producing bacteria, with special reference to beta-lactam antibiotics.
    Microbiol Rev. 1981 Dec;45(4):591-619 PMID: 7035856
  20. Escherichia coli resistance to beta-lactam antibiotics through a decrease in the affinity of a target for lethality.
    Nature. 1978 Aug 17;274(5672):713-5 PMID: 209344
  21. Staphylococcus saprophyticus: a frequent cause of acute urinary tract infection among female outpatients.
    J Infect Dis. 1978 Dec;138(6):791-7 PMID: 739158
  22. Closely related plasmids from Staphylococcus aureus and soil bacilli.
    Plasmid. 1982 Mar;7(2):152-62 PMID: 7079389
  23. In vitro activity of N-formimidoyl thienamycin (MK0787).
    Antimicrob Agents Chemother. 1980 Oct;18(4):642-4 PMID: 6934708
  24. Staphylococci as urinary pathogens.
    J Clin Pathol. 1977 May;30(5):427-31 PMID: 864011
  25. Coagulase-negative staphylococci and micrococci in urinary tract infections.
    J Clin Pathol. 1975 Apr;28(4):270-3 PMID: 1127120
  26. Endocarditis due to Micrococci and Staphylococcus epidermidis.
    Arch Intern Med. 1973 Aug;132(2):216-20 PMID: 4489733
  27. Trapping of nonhydrolyzable cephalosporins by cephalosporinases in Enterobacter cloacae and Pseudomonas aeruginosa as a possible resistance mechanism.
    Antimicrob Agents Chemother. 1982 May;21(5):711-7 PMID: 6808912
  28. Common R-plasmids in Staphylococcus aureus and Staphylococcus epidermidis during a nosocomial Staphylococcus aureus outbreak.
    Antimicrob Agents Chemother. 1982 Feb;21(2):210-5 PMID: 6918205
  29. Antibiotic tolerance in producer organisms.
    Adv Appl Microbiol. 1979;25:147-68 PMID: 94753
  30. Alteration of 23 S ribosomal RNA and erythromycin-induced resistance to lincomycin and spiramycin in Staphylococcus aureus.
    J Mol Biol. 1973 Feb 15;74(1):67-72 PMID: 4731016
Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.24.1.61
Published
1983-07-00
Pages
61-9
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC185105
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.24.1.61 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2