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PMID: 6985352 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Recurrent idiotopes and internal images.

The EMBO journal ·Vol. 1 ·No. 2 ·1982-00-00 ·Pages 243-7

Jerne NK, Roland J, Cazenave PA

Abstract

A rabbit was immunized with rabbit immunoglobulins of a different allotype. The anti-allotypic antibodies produced by this rabbit were used to immunize a second rabbit which produced anti-idiotypic antibodies. To explain the occurrence, among these anti-idiotypic antibodies, of "internal images" of the original immunizing allotype, a restricted and a more general hypothesis are developed. The first assumes that B-cells can be triggered when idiotopes on their receptor molecules are recognized by the paratopes of the immunizing antibody. The second denies the existence of a specially constructed combining site on the variable domain of an antibody molecule.

MeSH Terms
Animals Antibodies, Anti-Idiotypic/isolation & purification Immunization Immunoglobulin Allotypes/immunology Immunoglobulin Idiotypes/immunology Isoelectric Focusing Rabbits
Chemicals
Antibodies, Anti-Idiotypic Immunoglobulin Allotypes Immunoglobulin Idiotypes
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Jerne N K
Roland J
Cazenave P A
References (51)
51 references, click to expand
  1. Anti-idiotypic antibodies against anti-vitamin A transporting protein react with prealbumin.
    Nature. 1978 Jan 12;271(5641):167-8 PMID: 74803
  2. Similar idiotypic specificities in immunoglobulin fractions with different antibody functions or even without detectable antibody function.
    Proc Natl Acad Sci U S A. 1971 Oct;68(10):2616-20 PMID: 4109410
  3. Cross-idiotypic specificity among monoclonal IgM proteins with anti- -globulin activity.
    J Exp Med. 1973 Feb 1;137(2):331-42 PMID: 4119588
  4. Speculations. How specific are antibodies?
    Immunochemistry. 1973 Aug;10(8):545-53 PMID: 4128437
  5. Idiotypic-anti-idiotypic regulation of antibody synthesis in rabbits.
    Proc Natl Acad Sci U S A. 1977 Nov;74(11):5122-5 PMID: 270748
  6. Analysis of the repertoire of anti-NP antibodies in C57BL/6 mice by cell fusion. I. Characterization of antibody families in the primary and hyperimmune response.
    Eur J Immunol. 1978 Jun;8(6):393-400 PMID: 97089
  7. Induction of antiphosphorylcholine antibody formation by anti-idiotypic antibodies.
    J Exp Med. 1975 Nov 1;142(5):1121-32 PMID: 53257
  8. Towards a network theory of the immune system.
    Ann Immunol (Paris). 1974 Jan;125C(1-2):373-89 PMID: 4142565
  9. ANTI-ANTIBODY OR CLONE-PRODUCT?
    Nature. 1964 Feb 15;201:687-9 PMID: 14134711
  10. Genetic regulation of immunoglobulin synthesis.
    J Cell Physiol. 1966 Jun;67(3):Suppl 1:77-108 PMID: 5964890
  11. Cross idiotypic specificity among cold agglutinins in relation to combining activity for blood group-related antigens.
    Clin Exp Immunol. 1974 Oct;18(2):283-93 PMID: 4468199
  12. Idiotypic regulation of the immune system by the induction of antibodies against anti-idiotypic antibodies.
    Proc Natl Acad Sci U S A. 1977 Nov;74(11):5126-30 PMID: 303775
  13. A simple chromatographic method for preparation of gamma globulin.
    Proc Soc Exp Biol Med. 1960 Jan;103:250-2 PMID: 14416397
  14. Inherited immunoglobulin idiotypes of the mouse.
    Immunol Rev. 1977;34:119-38 PMID: 66781
  15. Anti-alprenolol anti-idiotypic antibodies bind to beta-adrenergic receptors and modulate catecholamine-sensitive adenylate cyclase.
    Proc Natl Acad Sci U S A. 1980 Dec;77(12):7385-9 PMID: 6261254
  16. Synthesis of antibodies and immunoglobulins bearing recipient allotypic markers and donor idiotypic specificities in irradiated rabbits grafted with allogeneic cells from hyperimmune donors.
    Ann Immunol (Paris). 1979 May-Jun;130C(3):397-406 PMID: 475344
  17. Glutaraldehyde-activated aminohexyl- derivative of Sepharose 4B as a new verstile immunoabsorbent.
    Immunochemistry. 1975 Apr;12(4):273-8 PMID: 811545
  18. [Idiotypic determinants in the rabbit similar as to anti-TMV antibodies with regard to different variants of allotypic specificity a1].
    Ann Immunol (Paris). 1977 Jan-Mar;128(1-2):355-9 PMID: 66901
  19. Analysis of the repertoire of anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibodies in C 57 BL/6 mice by cell fusion. II. Characterization of idiotopes by monoclonal anti-idiotope antibodies.
    Eur J Immunol. 1979 Dec;9(12):1004-13 PMID: 398773
  20. Antigen-binding, idiotypic T-lymphocyte receptors.
    Contemp Top Immunobiol. 1977;7:113-77 PMID: 69514
  21. [A new allotype form of rabbit serum gamma-globulins, apparently associated with antibody function and specificity].
    C R Hebd Seances Acad Sci. 1963 Jul 17;257:805-8 PMID: 13940767
  22. Individual Antigenic Specificity of Isolated Antibodies.
    Science. 1963 Jun 14;140(3572):1218-9 PMID: 17837506
  23. Assessing B cell diversification by antigen receptor and precursor cell analysis.
    Ann Immunol (Paris). 1976 Jun-Jul;127(3-4):489-502 PMID: 60906
  24. Genetic control of the immune response to the GAT terpolymer. I. Interstrain and interspecies cross-reactive idiotype.
    Ann Immunol (Paris). 1978 Jul-Sep;129 C(5):721-6 PMID: 104654
  25. Antibodies with multiple binding functions. Induction of single immunoglobin species by structurally dissimilar haptens.
    Proc Natl Acad Sci U S A. 1973 Nov;70(11):3269-74 PMID: 4131746
  26. B 96, a seventh allele at the rabbit kappa chain b locus.
    Eur J Immunol. 1981 Apr;11(4):344-6 PMID: 6788571
  27. Sharing of idiotypic specificities between different antibody populations from an individual rabbit.
    Eur J Immunol. 1975 Aug;5(8):570-5 PMID: 61876
  28. Precise determination of protein antigenic structures has unravelled the molecular immune recognition of proteins and provided a prototype for synthetic mimicking of other protein binding sites.
    Mol Cell Biochem. 1980 Aug 29;32(1):21-43 PMID: 6160381
  29. Isolation and characterization of rabbit antibodies directed against group a allotypic determinants.
    J Immunol. 1976 Feb;116(2):387-91 PMID: 814161
  30. Structural studies on induced antibodies with defined idiotypic specificities--VIII. NH2-terminal amino acid sequence analysis of the heavy and light chain variable regions of monoclonal anti-para-azophenylarsonate antibodies from A/J mice differing with respect to a cross-reactive idiotype.
    Mol Immunol. 1979 Dec;16(12):1111-8 PMID: 120496
  31. Idiotypic cross-reactivity between antibodies of different specificities.
    J Exp Med. 1978 Dec 1;148(6):1488-97 PMID: 82603
  32. Structural and serological relationships among different antibodies from the same rabbit antiserum. II. The idiotypes of ten antibody components from an anti-streptococcal serum.
    Eur J Immunol. 1976 Oct;6(10):727-32 PMID: 65143
  33. Cross-idiotypic reactions among anti-Rh (D) antibodies.
    Scand J Immunol. 1977;6(10):997-1003 PMID: 411166
  34. Epitope-specific and idiotype-specific cellular interactions in a model protein antigen system.
    Springer Semin Immunopathol. 1980 Aug;3(2):145-70 PMID: 6168023
  35. Induction of T and B cell immunity by anti-idiotypic antibody.
    Eur J Immunol. 1975 Oct;5(10):661-6 PMID: 11993330
  36. Sharing of an idiotypic marker by monoclonal antibodies specific for distinct regions of hen lysozyme.
    Nature. 1980 Oct 9;287(5782):540-2 PMID: 6158685
  37. Rabbit immunoglobulin allotypy: a sixth allele at the b locus (b 95).
    Mol Immunol. 1979 Dec;16(12):983-7 PMID: 120498
  38. Isoelectric focusing in polyacrylamide gel and its application to immunoglobulins.
    Nature. 1968 Jul 6;219(5149):66-7 PMID: 4173351
  39. Idiotypic analysis of antibodies to poly(Glu60Ala30Tyr10): interstrain and interspecies idiotypic crossreactions.
    Proc Natl Acad Sci U S A. 1978 Dec;75(12):6192-6 PMID: 282636
  40. Use of anti-idiotypic antibodies as cell-surface receptor probes.
    Proc Natl Acad Sci U S A. 1978 May;75(5):2443-7 PMID: 307766
  41. THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.
    Biochem J. 1963 Oct;89:114-23 PMID: 14097352
  42. Idiotypes as variable region markers: analogies between receptors on phosphorylcholine-specific T and B lymphocytes.
    Immunol Rev. 1977;34:3-33 PMID: 322367
  43. A theory of regulation and self-nonself discrimination in an immune network.
    Eur J Immunol. 1975 Sep;5(9):638-47 PMID: 11993326
  44. Expression and function of idiotypes of lymphocytes.
    Adv Immunol. 1978;26:195-254 PMID: 80953
  45. [Evidence of similar anti-b4 idiotypes in a3+ phenotype rabbits immunized against the b4 allotype].
    C R Seances Acad Sci D. 1979 Feb 5;288(5):571-4 PMID: 108029
  46. Presence of highly conserved idiotypic determinants in a family of antibodies that constitute an intrastrain cross-reactive idiotype.
    J Exp Med. 1980 Sep 1;152(3):703-11 PMID: 6157773
  47. Rabbits immunized against b6 allotype express similar anti-b6 idiotopes.
    Eur J Immunol. 1981 Jun;11(6):469-74 PMID: 6167450
  48. Clonal nature of the immune response to phosphorylcholine. IV. Idiotypic uniformity of binding site-associated antigenic determinants among mouse antiphosphorylcholine antibodies.
    J Exp Med. 1974 Sep 1;140(3):673-86 PMID: 4137581
  49. A common idiotypic specificity of rabbit antibodies to the a2 allotype of the immunoglobulin heavy chain variable region.
    J Immunol. 1980 Jul;125(1):96-101 PMID: 6770004
  50. Structural studies on induced antibodies with defined idiotypic specificities. IX. Framework differences in the heavy- and light-chain-variable regions of monoclonal anti-p-azophenylarsonate antibodies from A/J mice differing with respect to a cross-reactive idiotype.
    J Exp Med. 1980 Apr 1;151(4):863-75 PMID: 6768828
  51. A method for typing rabbit sera for the A14 and A15 allotypes with cross-linked antisera.
    J Immunol. 1970 Oct;105(4):1046-8 PMID: 5470519
Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1982-00-00
Pages
243-7
Language
English
Region
England
NLM ID
8208664
PMCID
PMC553027
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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