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PMID: 7868116 Published · ppublish English Journal Article

Chromosomal localization of the human NF-E2 family of bZIP transcription factors by fluorescence in situ hybridization.

Human genetics ·Vol. 95 ·No. 3 ·1995-03-00 ·Pages 265-9

Chan JY, Cheung MC, Moi P, Chan K, Kan YW

Abstract

A family of human genes encoding basic-leucine zipper (bZIP) transcription factors, p45-NF-E2, Nrf1 and Nrf2, have been isolated independently. Whereas the encoded proteins of the three genes share highly conserved regions distinct from other bZIP families such as Jun or Fos, remaining regions diverged considerably from each other. Chromosomal localization by fluorescence in situ hybridization demonstrates that these genes are non-syntenic. p45-NF-E2 mapped to chromosome 12q13.1-13.3, whereas Nrf1 and 2 mapped to 17q21.3 and 2q31, respectively. However, these three genes were probably derived from a single ancestor by chromosomal duplication as other genes that also map in these regions are related to one another.

Related Genes
NF-E2 Nrf1 Nrf2 p45
MeSH Terms
Amino Acid Sequence Base Sequence Chromosome Mapping/methods Chromosomes, Human, Pair 12 Chromosomes, Human, Pair 17 Chromosomes, Human, Pair 2 Conserved Sequence DNA-Binding Proteins/genetics Erythroid-Specific DNA-Binding Factors Humans In Situ Hybridization, Fluorescence Leucine Zippers/genetics Molecular Sequence Data Multigene Family NF-E2 Transcription Factor NF-E2 Transcription Factor, p45 Subunit NF-E2-Related Factor 2 Nuclear Respiratory Factor 1 Nuclear Respiratory Factors Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid Trans-Activators/genetics Transcription Factors/genetics
Chemicals
DNA-Binding Proteins Erythroid-Specific DNA-Binding Factors NF-E2 Transcription Factor NF-E2 Transcription Factor, p45 Subunit NF-E2-Related Factor 2 NFE2 protein, human NFE2L2 protein, human NRF1 protein, human Nuclear Respiratory Factor 1 Nuclear Respiratory Factors Trans-Activators Transcription Factors
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Chan J Y
Department of Laboratory Medicine, University of California, San Francisco 94143-0724.
Cheung M C
Moi P
Chan K
Kan Y W
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Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00225191
Published
1995-03-00
Pages
265-9
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00225191 View journal details
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