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PMID: 8504255 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Gene regulation: translational initiation by internal ribosome binding.

Current opinion in genetics & development ·Vol. 3 ·No. 2 ·1993-04-00 ·Pages 295-300

Oh SK, Sarnow P

Abstract

During the past year, several examples of cellular mRNAs have been described in which translational initiation occurs by internal ribosome binding, a mechanism hitherto thought to be restricted to picornaviral RNAs. New insights into the molecular mechanism of internal ribosome entry have been provided by the structural and functional analyses of both the internal ribosome entry sites and the protein factors that stimulate translation mediated by these elements.

Related Genes
Antp
MeSH Terms
Animals Antennapedia Homeodomain Protein Base Sequence Binding Sites DNA-Binding Proteins/genetics Drosophila Proteins Drosophila melanogaster/genetics Gene Expression Regulation Gene Expression Regulation, Viral Homeodomain Proteins Molecular Sequence Data Nuclear Proteins Peptide Chain Initiation, Translational RNA Viruses/genetics RNA, Messenger/metabolism RNA, Viral/metabolism Regulatory Sequences, Nucleic Acid Ribosomes/metabolism Transcription Factors
Chemicals
Antennapedia Homeodomain Protein Antp protein, Drosophila DNA-Binding Proteins Drosophila Proteins Homeodomain Proteins Nuclear Proteins RNA, Messenger RNA, Viral Transcription Factors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Oh S K
Department of Biochemistry, Biophysics and Genetics, University of Colorado Health Sciences Center, Denver 80262.
Sarnow P
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53 references, click to expand
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Article Info
Journal
Current opinion in genetics & development
Abbr.
Curr Opin Genet Dev
ISSN
0959-437X
DOI
10.1016/0959-437x(93)90037-p
Published
1993-04-00
Pages
295-300
Language
English
Region
England
NLM ID
9111375
PMCID
PMC7133282
Subset
IM
Grants
NIA NIH HHS · AG 07347 · United States
NIAID NIH HHS · AI25105 · United States
External Links
PubMed source DOI: 10.1016/0959-437x(93)90037-p PMC Full Text View journal details
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