Home LiteratureArticle Details
PMID: 934025 Published · ppublish English Journal Article

Persistent infection of tissue culture cells by RNA viruses.

Medical microbiology and immunology ·Vol. 162 ·No. 2 ·1976-06-01 ·Pages 89-119

Rima RK, Martin SJ

Abstract

In this paper, the characteristics of cultured cells persistently infected with RNA viruses, other than leuko viruses are described. The roles that the host cell, interferon, virus mutants and defective interfering particles may play in the establishment and maintenance of persistent infection are discussed. It is proposed that the interaction of viruses with certain types of host cells can lead to persistent infection. The differences in virus-host interactions may be attributable to differences in membrane properties of various cells. Defective interfering particles may play a role in the establishment of persistent infections in cells which normally undergo lytic virus development. Mutant types of virus appear to be prominent in the virus released from persistently infected cells, but the role that various mutants play in the maintenance of persistent infections remains unclear.

MeSH Terms
Antibodies, Viral Antigens, Viral Cell Membrane Cells, Cultured Humans In Vitro Techniques Infections Interferons Measles virus Mutation RNA Viruses Viral Interference Virus Cultivation
Chemicals
Antibodies, Viral Antigens, Viral Interferons
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Rima R K
Martin S J
References (104)
104 references, click to expand
  1. Virus specific antibodies in multiple sclerosis.
    Br Med J. 1972 Aug 19;3(5824):471 PMID: 4341646
  2. Cyclic production of vesicular stomatitis virus caused by defective interfering particles.
    J Infect Dis. 1974 Apr;129(4):402-10 PMID: 4361583
  3. Subacute sclerosing panencephalitis measles virus: study of biological markers.
    J Virol. 1973 Sep;12(3):632-42 PMID: 4201124
  4. Persistent infection of cells in culture by measles virus. II. Effect of measles antibody on persistently infected HeLa sublines and recovery of a HeLa clonal line persistently infected with incomplete virus.
    J Bacteriol. 1966 Dec;92(6):1805-11 PMID: 5334769
  5. Integration of measles virus nucleic acid into the cell genome.
    Arch Gesamte Virusforsch. 1974;45(3):225-34 PMID: 4138477
  6. Isolation of measles virus from cell cultures of brain from a patient with subacute sclerosing panencephalitis.
    N Engl J Med. 1969 Sep 11;281(11):585-9 PMID: 4980073
  7. Interfering particles from a culture persistently infected with Parana virus.
    J Gen Virol. 1974 Mar;22(3):437-40 PMID: 4361922
  8. Activation of a latent measles virus infection in hamster cells.
    J Virol. 1973 Oct;12(4):690-5 PMID: 4204692
  9. Comparison of antibodies against different viruses in cerebrospinal fluid and serum samples from patients with multiple sclerosis.
    Infect Immun. 1974 Oct;10(4):688-94 PMID: 4372178
  10. Persistent infection of cells in culture by measles virus. I. Development and characteristics of HeLa sublines persistently infected with complete virus.
    J Bacteriol. 1966 Dec;92(6):1792-804 PMID: 4163412
  11. Antibody-induced redistribution of measles virus antigens on the cell surface.
    J Immunol. 1974 Oct;113(4):1205-9 PMID: 4606230
  12. Specific movement of cell membranes fused with HVJ (Sendai virus).
    Proc Natl Acad Sci U S A. 1974 May;71(5):2043-7 PMID: 4365583
  13. Isolation and characterization of subacute sclerosing panencephalitis virus nucleocapsids.
    J Virol. 1972 Dec;10(6):1220-7 PMID: 4118868
  14. Antibody-induced capping of measles virus antigens on plasma membrane studied by electron microscopy.
    J Virol. 1975 May;15(5):1248-55 PMID: 49437
  15. Defectiveness of interferon production and of rubella virus interference in a line of African green monkey kidney cells (Vero).
    J Virol. 1968 Oct;2(10):955-61 PMID: 4302013
  16. Persistent infection of mouse cells with Sindbis virus: role of virulence of strains, auto-interfering particles and interferon.
    J Gen Virol. 1973 Jul;20(1):105-10 PMID: 4356681
  17. A persistent and inapparent infection of L cells with the virus of lymphocytic choriomeningitis.
    J Gen Virol. 1969 Jul;5(1):63-81 PMID: 4186351
  18. The prolonged persistence of western equine encephalomyelitis virus in cultures of strain L cells.
    Virology. 1957 Feb;3(1):62-75 PMID: 13409760
  19. Selection of temperature-sensitive mutants during persistent infection: role in maintenance of persistent Newcastle disease virus infections of L cells.
    J Virol. 1973 Sep;12(3):481-91 PMID: 4795831
  20. Growth of Newcastle disease virus in a HVJ carrier culture of HeLa cells.
    Virology. 1966 Jun;29(2):255-63 PMID: 5943537
  21. Peristence of sindbis virus in BHK-21 cell cultures.
    Arch Gesamte Virusforsch. 1972;38(1):1-10 PMID: 5066350
  22. Characterization of rabies viruses recovered from persistently infected BHK cells.
    Virology. 1975 Oct;67(2):520-33 PMID: 171839
  23. Defective interfering particles produced during the replication of measles virus.
    Med Microbiol Immunol. 1974;160(2-3):155-64 PMID: 4216759
  24. Inhibition and reversal of capping by cytochalasin B, vinblastine and colchicine.
    Nature. 1974 Jul 5;250(461):54-6 PMID: 4841158
  25. Cells persistently infected with newcastle disease virus: I. Properties of mutants isolated from persistently infected L cells.
    J Virol. 1969 Sep;4(3):244-51 PMID: 16789100
  26. Chronic rabies virus infection of cell cultures.
    Infect Immun. 1972 Dec;6(6):988-95 PMID: 4344636
  27. Persistent noncytocidal vesicular stomatitis virus infections mediated by defective T particles that suppress virion transcriptase.
    Proc Natl Acad Sci U S A. 1974 Aug;71(8):2956-60 PMID: 4370255
  28. Characterization of an in vitro persistent-state measles virus infection: establishment and virological characterization of the BGM/MV cell line.
    Infect Immun. 1975 Jan;11(1):152-8 PMID: 803920
  29. "Giant-cell" and "strand-forming" cytopathic effect of measles virus lines conditioned by serial propagation with diluted or concentrated inoculum.
    Virology. 1961 Apr;13:550-3 PMID: 13730253
  30. Studies on the persistent infection with measles virus in HeLa cells. II. The properties of carried virus.
    Jpn J Microbiol. 1971 Jul;15(4):333-40 PMID: 5000618
  31. RNA-dependent DNA polymerase activity in preparations of a mutant of Newcastle disease virus arising from persistently infected L cells.
    J Virol. 1973 Sep;12(3):548-55 PMID: 4127031
  32. Fluctuations and distribution of measles virus antigens in chronically infected cells.
    Nature. 1974 Apr 19;248(5450):691-3 PMID: 4598152
  33. Studies on the persistent infection with measles virus in HeLa cells. I. Clonal analysis of cells of carrier cultures.
    Jpn J Microbiol. 1971 Jul;15(4):325-31 PMID: 4940414
  34. Temperature-sensitive viruses and the etiology of chronic and inapparent infections.
    J Infect Dis. 1975 Apr;131(4):467-73 PMID: 163873
  35. Ribonucleic acid transcriptases in Sendai Virions and infected cells.
    J Virol. 1971 Aug;8(2):174-80 PMID: 4329968
  36. Temperature-sensitive mutants isolated from L cells persistently infected with Newcastle disease virus.
    J Virol. 1972 Feb;9(2):200-6 PMID: 5062677
  37. Integration of viral genomes.
    Nature. 1975 Aug 7;256(5517):471-3 PMID: 51475
  38. Characterization of an in vitro persistent-state measles virus infection: species characterization and interference in the BGM/MV cell line.
    Infect Immun. 1975 Jan;11(1):159-63 PMID: 163789
  39. Analysis of a viral agent isolated from multiple sclerosis brain tissue: characterization as a parainfluenzavirus type 1.
    J Virol. 1974 May;13(5):1037-45 PMID: 4363249
  40. Studies on persistent infections of tissue cultures. I. General aspects of the system.
    J Exp Med. 1958 Oct 1;108(4):537-60 PMID: 13575683
  41. Inhibition of measles virus replication and RNA synthesis by actinomycin D.
    Biochem Biophys Res Commun. 1972 Aug 7;48(3):657-61 PMID: 4625867
  42. [The production and maintenance of a virus carrier state: the possible role of homologous interference].
    Virology. 1960 Feb;10:198-210 PMID: 13848562
  43. Transcribing complexes in cells infected by vesicular stomatitis virus and rabies virus.
    J Virol. 1974 Sep;14(3):441-50 PMID: 4369391
  44. Modification of normal cell surface by smooth membrane preparations from BHK-21 cells infected with Newcastle disease virus.
    Med Microbiol Immunol. 1975 Jul 2;161(3):175-88 PMID: 1101009
  45. Persistent infection of cells in culture by measles virus. 3. Comparison of virus-specific RNA synthesized in primary persistent infection in HeLa cells.
    J Virol. 1973 Jun;11(6):926-32 PMID: 4576519
  46. Defective interfering viruses.
    Annu Rev Microbiol. 1973;27:101-17 PMID: 4356530
  47. Fusion of cultured multiple-sclerosis brain cells with indicator cells: presence of nucleocapsids and virions and isolation of parainfluenza-type virus.
    Lancet. 1972 Jul 1;2(7766):1-5 PMID: 4113621
  48. A carrier state of mumps virus in human conjunctiva cells. II. Observations on intercellular transfer of virus and virus release.
    J Exp Med. 1962 Nov 1;116:751-8 PMID: 13998480
  49. The production of a temperature-sensitive persistent measles virus infection.
    J Gen Virol. 1975 Jul;28(1):21-8 PMID: 1099170
  50. Cells persistently infected with Newcastle disease virus. 3. Thermal stability of hemagglutinin and neuraminidase of a mutant isolated from persistently infected L cells.
    J Virol. 1971 Jan;7(1):53-8 PMID: 5101091
  51. Studies on the persistent infection with measles virus in HeLa cells. 3. Immunolysis of cells in carrier state by anti-measles sera.
    Jpn J Microbiol. 1971 Jul;15(4):341-50 PMID: 5000619
  52. Immunologic injury in measles virus infection. II. Suppression of immune injury through antigenic modulation.
    J Exp Med. 1975 Oct 1;142(4):864-76 PMID: 1176889
  53. Some characteristics of SSPE measles virus.
    Proc Soc Exp Biol Med. 1970 May;134(1):17-21 PMID: 5423500
  54. PERSISTENT INFECTION OF HUMAN CONJUNCTIVA CELL CULTURES BY MYXOVIRUS PARAINFLUENZA 3.
    Can J Microbiol. 1965 Jun;11:513-21 PMID: 14346128
  55. Temperature-sensitive phenomenon of viral maturation observed in BHK cells persistently infected with HVJ.
    Virology. 1972 Aug;49(2):453-61 PMID: 4559687
  56. On the role of the response of the cell membrane in determining virus virulence. Contrasting effects of the parainfluenza virus SV5 in two cell types.
    J Exp Med. 1966 Sep 1;124(3):501-20 PMID: 4288512
  57. Defective viral particles and viral disease processes.
    Nature. 1970 Apr 25;226(5243):325-7 PMID: 5439728
  58. Persistent infection of continuous line of pig kidney cells with a variant of the WSN strain of influenza A 0 virus.
    Proc Soc Exp Biol Med. 1972 May;140(1):109-17 PMID: 5033080
  59. STUDIES ON PERSISTENT INFECTIONS OF TISSUE CULTURES. V. THE INITIAL STAGES OF INFECTION OF L(MCN) CELLS BY NEWCASTLE DISEASE VIRUS.
    J Exp Med. 1964 Jan 1;119:895-921 PMID: 14178459
  60. Temperature-sensitive defect of mutants isolated from L cells persistently infected with Newcastle disease virus.
    J Virol. 1973 Sep;12(3):472-80 PMID: 4795830
  61. Comparison of 6-94 virus and Sendai virus RNA by RNA-RNA hybridization.
    J Virol. 1974 Apr;13(4):935-6 PMID: 4362518
  62. Persistent infection of BSC-1 cells by defective measles virus derived from subacute sclerosing panencephalitis.
    Infect Immun. 1974 Dec;10(6):1378-82 PMID: 4215764
  63. Persistent infection of measles virus in mouse brain cell cultures infected in vivo.
    Arch Gesamte Virusforsch. 1972;37(1):45-53 PMID: 4112482
  64. Newcastle disease virus infection of L cells.
    J Virol. 1974 Jul;14(1):162-9 PMID: 4836600
  65. Modification of Newcastle disease virus release and cytopathogenicity in cells treated with plant lectins.
    J Gen Virol. 1974 Jun;23(3):255-70 PMID: 4836906
  66. Measles antibodies in multiple sclerosis.
    Proc Soc Exp Biol Med. 1962 Dec;111:562-6 PMID: 14011000
  67. Lectin-independent, irreversible redistribution of concanavalin A receptors on influenza virus infected Ehrlich ascites tumor cells.
    Arch Gesamte Virusforsch. 1974;44(4):377-85 PMID: 4859380
  68. Cell fusion by HeLa cells persistently infected with haemadsorption type 2 virus.
    J Gen Virol. 1974 Oct;25(1):117-24 PMID: 4372306
  69. Phenotypic mixing of envelope proteins of the parainfluenza virus SV5 and vesicular stomatitis virus.
    J Virol. 1970 May;5(5):609-16 PMID: 4315959
  70. Subacute sclerosing panencephalitis: isolation of measles virus from a brain biopsy.
    Nature. 1969 Mar 8;221(5184):974 PMID: 5765518
  71. Latency of human measles virus in hamster cells.
    J Virol. 1972 Nov;10(5):995-1001 PMID: 4117967
  72. Continuous mouse brain cell lines chronically infected with Japanese encephalitis virus.
    J Gen Virol. 1974 Aug;24(2):293-300 PMID: 4604271
  73. Replication of measles virus: distinct species of short nucleocapsids in cytoplasmic extracts of infected cells.
    J Virol. 1974 Mar;13(3):721-8 PMID: 4132672
  74. Persistent, noncytocidal viral infection: nonsynchrony of viral and cellular multiplication.
    J Bacteriol. 1966 Oct;92(4):983-9 PMID: 5926763
  75. Effect of puromycin and actinomycin D on a persistent mumps virus infection in vitro.
    J Virol. 1969 Aug;4(2):133-40 PMID: 5806982
  76. Measles and other virus-specific immunoglobulins in multiple sclerosis.
    Br Med J. 1973 Sep 22;3(5881):612-5 PMID: 4356870
  77. Cells persistently infected with Newcastle disease virus. II. Ribonucleic acid and protein synthesis in cells infected with mutants isolated from persistently infected L cells.
    J Virol. 1970 Jul;6(1):42-8 PMID: 5528542
  78. An interfering component of rabies virus which contains RNA.
    J Gen Virol. 1974 Jan;22(1):147-51 PMID: 4360392
  79. Association of measles antibody activity with electrophoretic fractions of CSF in a patient with multiple sclerosis.
    Acta Neurol Scand. 1973;49(2):266-8 PMID: 4718193
  80. A variant of measles virus in which giant cell formation appears to be genetically determined.
    Virology. 1959 Sep;9:143-5 PMID: 14444711
  81. A carrier state in HeLa cells with measles virus (Edmonston strain) apparently associated with non-infectious virus.
    Virology. 1962 Jan;16:101-4 PMID: 14495464
  82. Recovery of infectious proviral DNA from mammalian cells infected with respiratory syncytial virus.
    Proc Natl Acad Sci U S A. 1975 Aug;72(8):3230-4 PMID: 1103142
  83. Virus antibodies in serum specimens from patients with multiple sclerosis, from siblings, and matched controls. A final report.
    Acta Neurol Scand. 1973;49(1):85-107 PMID: 4684595
  84. Properties of defective lymphocytic choriomeningitis virus.
    J Gen Virol. 1972 Dec;17(3):355-9 PMID: 4650728
  85. Molecular events accompanying slow virus infections at the cellular level.
    Ann Inst Pasteur (Paris). 1972 Oct;123(4):553-63 PMID: 4632951
  86. ENDOSYMBIOTIC RELATIONSHIP BETWEEN ANIMAL VIRUSES AND HOST CELLS. A STUDY OF RABIES VIRUS IN TISSUE CULTURE.
    J Exp Med. 1964 Dec 1;120:1099-116 PMID: 14238928
  87. Virus antibody titers in multiple sclerosis patients, siblings, and controls.
    JAMA. 1971 May 31;216(9):1441-6 PMID: 4325395
  88. Temperature-sensitive virus derived from BHK cells persistently infected with HVJ (Sendai virus).
    J Virol. 1975 Jan;15(1):55-63 PMID: 163346
  89. Isolation of two plaque mutants of Western equine encephalitis virus differing in virulence for mice.
    J Virol. 1969 Nov;4(5):799-800 PMID: 5360528
  90. Arenaviruses: cellular response to long-term in vitro infection with parana and lymphocytic choriomeningitis viruses.
    Infect Immun. 1972 Oct;6(4):444-50 PMID: 4564281
  91. Aetiology of multiple sclerosis.
    Lancet. 1974 Jun 15;1(7868):1196-9 PMID: 4135000
  92. A carrier cell line of measles virus in Lu 106 cells.
    Arch Gesamte Virusforsch. 1967;20(2):215-24 PMID: 4299726
  93. Electron microscopic analysis of the modulation of lymphocyte receptor mobility.
    Exp Cell Res. 1975 Mar 1;91(1):125-42 PMID: 1132413
  94. THE VIRAL CARRIER STATE IN ANIMAL CELL CULTURES.
    Prog Med Virol. 1964;6:111-48 PMID: 14310569
  95. Immunoglobulin M specific for measles and mumps in multiple sclerosis.
    Br Med J. 1971 May 15;2(5758):378-80 PMID: 4325075
  96. PERSISTENT INFECTION IN HELA CELLS WITH HEMADSORPTION VIRUS TYPE 2.
    Virology. 1964 Dec;24:670-2 PMID: 14240419
  97. Relationship between neurovirulence and temperature sensitivity of an attenuated western equine encephalitis virus.
    Arch Gesamte Virusforsch. 1971;35(2):242-50 PMID: 5137591
  98. A carrier state of mumps virus in human conjunctiva cells. I. General characteristics.
    J Exp Med. 1962 Nov 1;116:739-50 PMID: 13998479
  99. The significance of failure to isolate infectious viruses in cases of subacute sclerosing panencephalitis. Brief report.
    Arch Gesamte Virusforsch. 1973;41(4):390-3 PMID: 4354241
  100. Temperature-sensitive virus from Aedes albopictus cells chronically infected with Sindbis virus.
    J Virol. 1974 Feb;13(2):439-47 PMID: 4855741
  101. Natural selection of mutants of vesicular stomatitis virus by cultured cells of Drosophila melanogaster.
    J Gen Virol. 1973 Sep;20(3):341-51 PMID: 4355329
  102. Characterization of virus-specific RNAs from subacute sclerosing panencephalitis virus-infected CV-1 cells.
    J Virol. 1973 Nov;12(5):962-8 PMID: 4203087
  103. Characteristics of the progeny derived from multiplication of Sendai virus in a measles virus carrier cell line.
    Arch Gesamte Virusforsch. 1965;17(3):436-42 PMID: 4286822
  104. Alterations in Sindbis viral enbelope proteins by treating BHK cells with glucosamine.
    J Virol. 1975 Feb;15(2):416-9 PMID: 1167605
Article Info
Journal
Medical microbiology and immunology
Abbr.
Med Microbiol Immunol
ISSN
0300-8584
DOI
10.1007/BF02121320
Published
1976-06-01
Pages
89-119
Language
English
Region
Germany
NLM ID
0314524
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02121320 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2