Home LiteratureArticle Details
PMID: 9445072 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Use of murine CXCR-4 as a second receptor by some T-cell-tropic human immunodeficiency viruses.

Journal of virology ·Vol. 72 ·No. 2 ·1998-02-00 ·Pages 1652-6

Parolin C, Borsetti A, Choe H, Farzan M, Kolchinsky P, Heesen M, Ma Q, Gerard C, Palú G, Dorf ME, Springer T, Sodroski J

Abstract

The human CXCR-4 molecule serves as a second receptor for primary, T-cell-tropic, and laboratory-adapted human immunodeficiency virus type 1 (HIV-1) isolates. Here we show that murine CXCR-4 can support the entry of some of these HIV-1 isolates. Differences between mouse and human CXCR-4 in the ability to function as an HIV-1 receptor are determined by sequences in the second extracellular loop of the CXCR-4 protein.

MeSH Terms
Animals HIV-1/physiology Humans Mice Receptors, CCR4 Receptors, Chemokine/physiology Receptors, Virus/physiology T-Lymphocytes/virology Virus Replication
Chemicals
CCR4 protein, human Ccr4 protein, mouse Receptors, CCR4 Receptors, Chemokine Receptors, Virus
Authors & Affiliations
12 authors, click to expand affiliations / ORCID
Parolin C
Division of Human Retrovirology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Borsetti A
Choe H
Farzan M
Kolchinsky P
Heesen M
Ma Q
Gerard C
Palú G
Dorf M E
Springer T
Sodroski J
References (64)
64 references, click to expand
  1. Three populations of cells with dendritic morphology exist in peripheral blood, only one of which is infectable with human immunodeficiency virus type 1.
    Proc Natl Acad Sci U S A. 1995 Jan 31;92(3):826-30 PMID: 7846060
  2. Distinct replicative and cytopathic characteristics of human immunodeficiency virus isolates.
    J Virol. 1988 Nov;62(11):4414-9 PMID: 2459416
  3. Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposure.
    Nat Med. 1996 Apr;2(4):412-7 PMID: 8597950
  4. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor.
    Science. 1996 May 10;272(5263):872-7 PMID: 8629022
  5. Molecular cloning and functional expression of a new human CC-chemokine receptor gene.
    Biochemistry. 1996 Mar 19;35(11):3362-7 PMID: 8639485
  6. Identification of a major co-receptor for primary isolates of HIV-1.
    Nature. 1996 Jun 20;381(6584):661-6 PMID: 8649511
  7. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5.
    Nature. 1996 Jun 20;381(6584):667-73 PMID: 8649512
  8. The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates.
    Cell. 1996 Jun 28;85(7):1135-48 PMID: 8674119
  9. Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS).
    Science. 1983 May 20;220(4599):868-71 PMID: 6189183
  10. NIH conference. Acquired immunodeficiency syndrome: epidemiologic, clinical, immunologic, and therapeutic considerations.
    Ann Intern Med. 1984 Jan;100(1):92-106 PMID: 6318629
  11. Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS.
    Science. 1984 May 4;224(4648):500-3 PMID: 6200936
  12. The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus.
    Nature. 1984 Dec 20-1985 Jan 2;312(5996):763-7 PMID: 6096719
  13. The productive infection of alveolar macrophages by simian immunodeficiency virus.
    J Med Primatol. 1989;18(3-4):217-26 PMID: 2474655
  14. Human immunodeficiency virus envelope glycoprotein/CD4-mediated fusion of nonprimate cells with human cells.
    J Virol. 1990 May;64(5):2149-56 PMID: 2109100
  15. Rapid complementation assays measuring replicative potential of human immunodeficiency virus type 1 envelope glycoprotein mutants.
    J Virol. 1990 May;64(5):2416-20 PMID: 2325207
  16. Viral determinants of human immunodeficiency virus type 1 T-cell or macrophage tropism, cytopathogenicity, and CD4 antigen modulation.
    J Virol. 1990 Sep;64(9):4390-8 PMID: 2384920
  17. HIV-1 tropism for mononuclear phagocytes can be determined by regions of gp120 outside the CD4-binding domain.
    Nature. 1990 Nov 1;348(6296):69-73 PMID: 2172833
  18. Macrophage and T cell-line tropisms of HIV-1 are determined by specific regions of the envelope gp120 gene.
    Nature. 1991 Jan 10;349(6305):167-9 PMID: 1986308
  19. Identification of a determinant within the human immunodeficiency virus 1 surface envelope glycoprotein critical for productive infection of primary monocytes.
    Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3097-101 PMID: 2014229
  20. Specific cell surface requirements for the infection of CD4-positive cells by human immunodeficiency virus types 1 and 2 and by Simian immunodeficiency virus.
    Virology. 1991 Apr;181(2):703-15 PMID: 1673040
  21. Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1.
    Science. 1991 Jul 5;253(5015):71-4 PMID: 1905842
  22. Macrophage-tropic variants of SIV are associated with specific AIDS-related lesions but are not essential for the development of AIDS.
    Am J Pathol. 1991 Jul;139(1):29-35 PMID: 1853937
  23. Identification of human immunodeficiency virus envelope gene sequences influencing viral entry into CD4-positive HeLa cells, T-leukemia cells, and macrophages.
    J Virol. 1991 Nov;65(11):5782-9 PMID: 1920616
  24. The region of the envelope gene of human immunodeficiency virus type 1 responsible for determination of cell tropism.
    J Virol. 1992 Jan;66(1):305-9 PMID: 1727490
  25. Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population.
    J Virol. 1992 Mar;66(3):1354-60 PMID: 1738194
  26. Macrophage tropism determinants of human immunodeficiency virus type 1 in vivo.
    J Virol. 1992 Apr;66(4):2577-82 PMID: 1548783
  27. Macrophage-tropic human immunodeficiency virus isolates from different patients exhibit unusual V3 envelope sequence homogeneity in comparison with T-cell-tropic isolates: definition of critical amino acids involved in cell tropism.
    J Virol. 1992 Nov;66(11):6547-54 PMID: 1404602
  28. Molecular cloning of the cDNA and chromosomal localization of the gene for a putative seven-transmembrane segment (7-TMS) receptor isolated from human spleen.
    Genomics. 1993 Jun;16(3):707-12 PMID: 8325644
  29. Identification of HIV1 determinants for T lymphoid cell line infection.
    Virology. 1993 Dec;197(2):817-24 PMID: 8249306
  30. Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes.
    J Biol Chem. 1994 Jan 7;269(1):232-7 PMID: 8276799
  31. HIV-2 and SIV infection of nonprimate cell lines expressing human CD4: restrictions to replication at distinct stages.
    Virology. 1994 May 15;201(1):8-18 PMID: 8178492
  32. Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1.
    Cell. 1994 Aug 12;78(3):389-98 PMID: 7914836
  33. A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors.
    Cell. 1996 Jun 28;85(7):1149-58 PMID: 8674120
  34. CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1.
    Science. 1996 Jun 28;272(5270):1955-8 PMID: 8658171
  35. Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1beta, and MIP-1alpha.
    J Biol Chem. 1996 Jul 19;271(29):17161-6 PMID: 8663314
  36. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry.
    Nature. 1996 Aug 29;382(6594):829-33 PMID: 8752280
  37. The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1.
    Nature. 1996 Aug 29;382(6594):833-5 PMID: 8752281
  38. Human immunodeficiency virus type 1 entry into murine cell lines and lymphocytes from transgenic mice expressing a glycoprotein 120-binding mutant mouse CD4.
    AIDS Res Hum Retroviruses. 1996 Jul 1;12(10):867-76 PMID: 8798971
  39. Evidence for cell-surface association between fusin and the CD4-gp120 complex in human cell lines.
    Science. 1996 Oct 25;274(5287):602-5 PMID: 8849450
  40. Regions in beta-chemokine receptors CCR5 and CCR2b that determine HIV-1 cofactor specificity.
    Cell. 1996 Nov 1;87(3):437-46 PMID: 8898197
  41. The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection.
    Nat Med. 1996 Nov;2(11):1244-7 PMID: 8898753
  42. CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5.
    Nature. 1996 Nov 14;384(6605):179-83 PMID: 8906795
  43. CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5.
    Nature. 1996 Nov 14;384(6605):184-7 PMID: 8906796
  44. Multiple extracellular elements of CCR5 and HIV-1 entry: dissociation from response to chemokines.
    Science. 1996 Dec 13;274(5294):1924-6 PMID: 8943208
  45. Cloning of the mouse fusin gene, homologue to a human HIV-1 co-factor.
    J Immunol. 1996 Dec 15;157(12):5455-60 PMID: 8955194
  46. Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin.
    Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14726-9 PMID: 8962122
  47. HIV-1 entry and macrophage inflammatory protein-1beta-mediated signaling are independent functions of the chemokine receptor CCR5.
    J Biol Chem. 1997 Mar 14;272(11):6854-7 PMID: 9054370
  48. Human immunodeficiency virus strains differ in their ability to infect CD4+ cells expressing the rat homolog of CXCR-4 (fusin).
    J Virol. 1997 Apr;71(4):3259-62 PMID: 9060691
  49. Alternate splicing of mouse fusin/CXC chemokine receptor-4: stromal cell-derived factor-1alpha is a ligand for both CXC chemokine receptor-4 isoforms.
    J Immunol. 1997 Apr 15;158(8):3561-4 PMID: 9103415
  50. HIV-1-induced cell fusion is mediated by multiple regions within both the viral envelope and the CCR-5 co-receptor.
    EMBO J. 1997 May 15;16(10):2599-609 PMID: 9184207
  51. T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV.
    Nature. 1984 Dec 20-1985 Jan 2;312(5996):767-8 PMID: 6083454
  52. Characterization of envelope and core structural gene products of HTLV-III with sera from AIDS patients.
    Science. 1985 May 3;228(4699):593-5 PMID: 2984774
  53. Major glycoprotein antigens that induce antibodies in AIDS patients are encoded by HTLV-III.
    Science. 1985 May 31;228(4703):1091-4 PMID: 2986290
  54. Binding of HTLV-III/LAV to T4+ T cells by a complex of the 110K viral protein and the T4 molecule.
    Science. 1986 Jan 24;231(4736):382-5 PMID: 3001934
  55. A second post-transcriptional trans-activator gene required for HTLV-III replication.
    Nature. 1986 May 22-28;321(6068):412-7 PMID: 3012355
  56. The role of mononuclear phagocytes in HTLV-III/LAV infection.
    Science. 1986 Jul 11;233(4760):215-9 PMID: 3014648
  57. Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy.
    Science. 1986 Sep 5;233(4768):1089-93 PMID: 3016903
  58. The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain.
    Cell. 1986 Nov 7;47(3):333-48 PMID: 3094962
  59. Induction of CD4-dependent cell fusion by the HTLV-III/LAV envelope glycoprotein.
    Nature. 1986 Oct 23-29;323(6090):725-8 PMID: 3095663
  60. pH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membrane.
    Cell. 1987 Jun 5;49(5):659-68 PMID: 3107838
  61. Functional regions of the envelope glycoprotein of human immunodeficiency virus type 1.
    Science. 1987 Sep 11;237(4820):1351-5 PMID: 3629244
  62. Biologic features of HIV-1 that correlate with virulence in the host.
    Science. 1988 Apr 1;240(4848):80-2 PMID: 2832945
  63. Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytes.
    J Exp Med. 1988 Apr 1;167(4):1428-41 PMID: 3258626
  64. Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells.
    Science. 1995 Dec 15;270(5243):1811-5 PMID: 8525373
Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.72.2.1652-1656.1998
Published
1998-02-00
Pages
1652-6
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC124650
Subset
IM
Grants
NIAID NIH HHS · AI 24755 · United States
NCI NIH HHS · CA 06516 · United States
NIAID NIH HHS · AI 28691 · United States
External Links
PubMed source DOI: 10.1128/JVI.72.2.1652-1656.1998 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2