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PMID: 9632612 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Low genetic diversity of Haemophilus influenzae type b compared to nonencapsulated H. influenzae in a population in which H. influenzae is highly endemic.

Infection and immunity ·Vol. 66 ·No. 7 ·1998-07-00 ·Pages 3403-9

Smith-Vaughan HC, Sriprakash KS, Leach AJ, Mathews JD, Kemp DJ

Abstract

Immunization with Haemophilus influenzae type b (Hib) conjugate polysaccharide vaccines has dramatically reduced Hib disease worldwide. As in other populations, nasopharyngeal carriage of Hib declined markedly in Aboriginal infants following vaccination, although carriage has not been entirely eliminated. In this study, we describe the genetic characteristics and the carriage dynamics of longitudinal isolates of Hib, characterized by using several typing methods. In addition, carriage rates of nonencapsulated H. influenzae (NCHi) are high, and concurrent colonization with Hib and NCHi is common; we also observed NCHi isolates which were genetically similar to Hib. There is a continuing need to promote Hib immunization and monitor H. influenzae carriage in populations in which the organism is highly endemic, not least because of the possibility of genetic exchange between Hib and NCHi strains in such populations.

MeSH Terms
Amoxicillin/pharmacology Bacterial Capsules/physiology Genetic Variation Haemophilus influenzae/drug effects,genetics,physiology Humans Polymerase Chain Reaction Vaccination beta-Lactamases/biosynthesis
Chemicals
Amoxicillin beta-Lactamases
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Smith-Vaughan H C
Menzies School of Health Research, Darwin, Northern Territory, Australia. [email protected]
Sriprakash K S
Leach A J
Mathews J D
Kemp D J
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/IAI.66.7.3403-3409.1998
Email
[email protected]
Published
1998-07-00
Pages
3403-9
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC108359
Subset
IM
External Links
PubMed source DOI: 10.1128/IAI.66.7.3403-3409.1998 PMC Full Text View journal details
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