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PMID: 9880478 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

The evolutionary biology and population genetics underlying fungal strain typing.

Clinical microbiology reviews ·Vol. 12 ·No. 1 ·1999-01-00 ·Pages 126-46

Taylor JW, Geiser DM, Burt A, Koufopanou V

Abstract

Strain typing of medically important fungi and fungal population genetics have been stimulated by new methods of tapping DNA variation. The aim of this contribution is to show how awareness of fungal population genetics can increase the utility of strain typing to better serve the interests of medical mycology. Knowing two basic features of fungal population biology, the mode of reproduction and genetic differentiation or isolation, can give medical mycologists information about the intraspecific groups that are worth identifying and the number and type of markers that would be needed to do so. The same evolutionary information can be just as valuable for the selection of fungi for development and testing of pharmaceuticals or vaccines. The many methods of analyzing DNA variation are evaluated in light of the need for polymorphic loci that are well characterized, simple, independent, and stable. Traditional population genetic and new phylogenetic methods for analyzing mode of reproduction, genetic differentiation, and isolation are reviewed. Strain typing and population genetic reports are examined for six medically important species: Coccidioides immitis, Histoplasma capsulatum, Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus, and A. flavus. Research opportunities in the areas of genomics, correlation of clinical variation with genetic variation, amount of recombination, and standardization of approach are suggested.

MeSH Terms
Biological Evolution Fungi/classification,genetics Genetics, Population Mycological Typing Techniques
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Taylor J W
Department of Plant and Microbial Biology, University of California, Berkeley, California 94720-3102, USA. [email protected]
Geiser D M
Burt A
Koufopanou V
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Article Info
Journal
Clinical microbiology reviews
Abbr.
Clin Microbiol Rev
ISSN
0893-8512
DOI
10.1128/CMR.12.1.126
Email
[email protected]
Published
1999-01-00
Pages
126-46
Language
English
Region
United States
NLM ID
8807282
PMCID
PMC88910
Subset
IM
External Links
PubMed source DOI: 10.1128/CMR.12.1.126 PMC Full Text View journal details
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