Home LiteratureArticle Details
PMID: 10952561 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Efflux-mediated resistance to fluoroquinolones in gram-negative bacteria.

Antimicrobial agents and chemotherapy ·Vol. 44 ·No. 9 ·2000-09-00 ·Pages 2233-41

Poole K

Abstract

暂无摘要

MeSH Terms
Anti-Infective Agents/metabolism,pharmacology Biological Transport/physiology Drug Resistance, Microbial/physiology Fluoroquinolones Gram-Negative Bacteria/drug effects,metabolism Humans
Chemicals
Anti-Infective Agents Fluoroquinolones
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Poole K
Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada. [email protected]
References (150)
150 references, click to expand
  1. Mechanisms of quinolone resistance in clinical strains of Pseudomonas aeruginosa.
    Microb Drug Resist. 1998 Winter;4(4):257-61 PMID: 9988043
  2. Mechanisms of quinolone resistance in Escherichia coli: characterization of nfxB and cfxB, two mutant resistance loci decreasing norfloxacin accumulation.
    Antimicrob Agents Chemother. 1989 Mar;33(3):283-90 PMID: 2658782
  3. Characterization of a Pseudomonas aeruginosa efflux pump contributing to aminoglycoside impermeability.
    Antimicrob Agents Chemother. 1999 Dec;43(12):2975-83 PMID: 10582892
  4. Genes acrA and acrB encode a stress-induced efflux system of Escherichia coli.
    Mol Microbiol. 1995 Apr;16(1):45-55 PMID: 7651136
  5. Selection of multiple antibiotic resistance by quinolones, beta-lactams, and aminoglycosides with special reference to cross-resistance between unrelated drug classes.
    Antimicrob Agents Chemother. 1984 Dec;26(6):797-801 PMID: 6098219
  6. Identification for mar mutants among quinolone-resistant clinical isolates of Escherichia coli.
    Antimicrob Agents Chemother. 1996 Jul;40(7):1695-8 PMID: 8807064
  7. Efflux pumps and drug resistance in gram-negative bacteria.
    Trends Microbiol. 1994 Dec;2(12):489-93 PMID: 7889326
  8. TolC, an Escherichia coli outer membrane protein required for hemolysin secretion.
    Proc Natl Acad Sci U S A. 1990 Jun;87(12):4776-80 PMID: 2112747
  9. The role of outer membrane and efflux pumps in the resistance of gram-negative bacteria. Can we improve drug access?
    Drug Resist Updat. 1998;1(2):93-8 PMID: 16904394
  10. The local repressor AcrR plays a modulating role in the regulation of acrAB genes of Escherichia coli by global stress signals.
    Mol Microbiol. 1996 Jan;19(1):101-12 PMID: 8821940
  11. Modulation of Neisseria gonorrhoeae susceptibility to vertebrate antibacterial peptides due to a member of the resistance/nodulation/division efflux pump family.
    Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1829-33 PMID: 9465102
  12. Type II topoisomerase mutations in ciprofloxacin-resistant strains of Pseudomonas aeruginosa.
    Antimicrob Agents Chemother. 1999 Jan;43(1):62-6 PMID: 9869566
  13. Influence of the TonB energy-coupling protein on efflux-mediated multidrug resistance in Pseudomonas aeruginosa.
    Antimicrob Agents Chemother. 1998 Sep;42(9):2225-31 PMID: 9736539
  14. Quantitative correlation between susceptibility and OprJ production in NfxB mutants of Pseudomonas aeruginosa.
    Antimicrob Agents Chemother. 1996 Apr;40(4):909-13 PMID: 8849250
  15. Overexpression of marA, soxS, or acrAB produces resistance to triclosan in laboratory and clinical strains of Escherichia coli.
    FEMS Microbiol Lett. 1998 Sep 15;166(2):305-9 PMID: 9770288
  16. The complete genome sequence of the gastric pathogen Helicobacter pylori.
    Nature. 1997 Aug 7;388(6642):539-47 PMID: 9252185
  17. Nucleotide sequence analysis of a gene from Burkholderia (Pseudomonas) cepacia encoding an outer membrane lipoprotein involved in multiple antibiotic resistance.
    Antimicrob Agents Chemother. 1996 Feb;40(2):307-13 PMID: 8834871
  18. Purification of a 54-kilodalton protein (OprJ) produced in NfxB mutants of Pseudomonas aeruginosa and production of a monoclonal antibody specific to OprJ.
    Antimicrob Agents Chemother. 1995 Aug;39(8):1731-5 PMID: 7486910
  19. Bypassing the periplasm: reconstitution of the AcrAB multidrug efflux pump of Escherichia coli.
    Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7190-5 PMID: 10377390
  20. Characterization of MexT, the regulator of the MexE-MexF-OprN multidrug efflux system of Pseudomonas aeruginosa.
    J Bacteriol. 1999 Oct;181(20):6300-5 PMID: 10515918
  21. Involvement of outer membrane protein TolC, a possible member of the mar-sox regulon, in maintenance and improvement of organic solvent tolerance of Escherichia coli K-12.
    J Bacteriol. 1998 Feb;180(4):938-44 PMID: 9473050
  22. The MexA-MexB-OprM multidrug efflux system of Pseudomonas aeruginosa is growth-phase regulated.
    FEMS Microbiol Lett. 1999 Apr 1;173(1):35-9 PMID: 10220878
  23. Mechanisms of quinolone resistance in a clinical isolate of Escherichia coli highly resistant to fluoroquinolones but susceptible to nalidixic acid.
    Antimicrob Agents Chemother. 1991 Mar;35(3):519-23 PMID: 2039202
  24. Involvement of an efflux system in high-level fluoroquinolone resistance of Shigella dysenteriae.
    Biochem Biophys Res Commun. 1998 Jan 6;242(1):54-6 PMID: 9439608
  25. Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori.
    Nature. 1999 Jan 14;397(6715):176-80 PMID: 9923682
  26. DNA gyrase gyrA mutations in quinolone-resistant clinical isolates of Pseudomonas aeruginosa.
    Antimicrob Agents Chemother. 1995 Sep;39(9):1970-2 PMID: 8540700
  27. Development of multiple-antibiotic-resistant (Mar) mutants of Pseudomonas aeruginosa after serial exposure to fluoroquinolones.
    Antimicrob Agents Chemother. 1995 Feb;39(2):489-95 PMID: 7726519
  28. Energy-dependent accumulation of fluoroquinolones in quinolone-resistant Klebsiella pneumoniae strains.
    Antimicrob Agents Chemother. 1998 Jul;42(7):1850-2 PMID: 9661034
  29. Influence of mutations in the mexR repressor gene on expression of the MexA-MexB-oprM multidrug efflux system of Pseudomonas aeruginosa.
    J Bacteriol. 2000 Mar;182(5):1410-4 PMID: 10671465
  30. The Salmonella typhimurium mar locus: molecular and genetic analyses and assessment of its role in virulence.
    J Bacteriol. 1997 Mar;179(6):1857-66 PMID: 9068629
  31. Penetration of lipophilic agents with multiple protonation sites into bacterial cells: tetracyclines and fluoroquinolones as examples.
    Antimicrob Agents Chemother. 1993 Jul;37(7):1393-9 PMID: 8363364
  32. Active efflux of norfloxacin by Bacteroides fragilis.
    Antimicrob Agents Chemother. 1998 Aug;42(8):2119-21 PMID: 9687419
  33. Analysis of the mechanisms of quinolone resistance in clinical isolates of Citrobacter freundii.
    J Antimicrob Chemother. 1999 Dec;44(6):743-8 PMID: 10590274
  34. Mechanisms of high-level resistance to quinolones in urinary tract isolates of Pseudomonas aeruginosa.
    Antimicrob Agents Chemother. 1994 Jul;38(7):1466-9 PMID: 7979273
  35. Role of mutations in DNA gyrase genes in ciprofloxacin resistance of Pseudomonas aeruginosa susceptible or resistant to imipenem.
    Antimicrob Agents Chemother. 1995 Oct;39(10):2248-52 PMID: 8619577
  36. The mar regulon: multiple resistance to antibiotics and other toxic chemicals.
    Trends Microbiol. 1999 Oct;7(10):410-3 PMID: 10498949
  37. New norfloxacin resistance gene in Pseudomonas aeruginosa PAO.
    Antimicrob Agents Chemother. 1990 Sep;34(9):1757-61 PMID: 2126688
  38. The multidrug efflux protein NorM is a prototype of a new family of transporters.
    Mol Microbiol. 1999 Jan;31(1):394-5 PMID: 9987140
  39. Active efflux of organic solvents by Pseudomonas putida S12 is induced by solvents.
    J Bacteriol. 1998 Dec;180(24):6769-72 PMID: 9852029
  40. Influence of the MexAB-OprM multidrug efflux system on quorum sensing in Pseudomonas aeruginosa.
    J Bacteriol. 1998 Oct;180(20):5443-7 PMID: 9765578
  41. Function of the membrane fusion protein, MexA, of the MexA, B-OprM efflux pump in Pseudomonas aeruginosa without an anchoring membrane.
    J Biol Chem. 2000 Feb 18;275(7):4628-34 PMID: 10671490
  42. Non-target gene mutations in the development of fluoroquinolone resistance in Escherichia coli.
    Antimicrob Agents Chemother. 2000 Apr;44(4):814-20 PMID: 10722475
  43. Role of the multidrug efflux systems of Pseudomonas aeruginosa in organic solvent tolerance.
    J Bacteriol. 1998 Jun;180(11):2987-91 PMID: 9603892
  44. Use of a genetic approach to evaluate the consequences of inhibition of efflux pumps in Pseudomonas aeruginosa.
    Antimicrob Agents Chemother. 1999 Jun;43(6):1340-6 PMID: 10348749
  45. Multiple antibiotic resistance in Pseudomonas aeruginosa: evidence for involvement of an efflux operon.
    J Bacteriol. 1993 Nov;175(22):7363-72 PMID: 8226684
  46. Resistance to pefloxacin in Pseudomonas aeruginosa.
    Antimicrob Agents Chemother. 1991 Mar;35(3):512-8 PMID: 1645509
  47. Resistance of Pseudomonas aeruginosa PAO to nalidixic acid and low levels of beta-lactam antibiotics: mapping of chromosomal genes.
    Antimicrob Agents Chemother. 1982 Aug;22(2):242-9 PMID: 6821455
  48. Characterization of MexE-MexF-OprN, a positively regulated multidrug efflux system of Pseudomonas aeruginosa.
    Mol Microbiol. 1997 Jan;23(2):345-54 PMID: 9044268
  49. Porin alteration and active efflux: two in vivo drug resistance strategies used by Enterobacter aerogenes.
    Microbiology. 1998 Nov;144 ( Pt 11):3003-9 PMID: 9846735
  50. Organic solvent-tolerant mutants of Pseudomonas aeruginosa display multiple antibiotic resistance.
    Can J Microbiol. 1999 Jan;45(1):18-22 PMID: 10349716
  51. Evidence for active efflux as the primary mechanism of resistance to ciprofloxacin in Salmonella enterica serovar typhimurium.
    Antimicrob Agents Chemother. 2000 May;44(5):1223-8 PMID: 10770755
  52. Molecular mechanisms of fluoroquinolone resistance in Pseudomonas aeruginosa isolates from cystic fibrosis patients.
    Antimicrob Agents Chemother. 2000 Mar;44(3):710-2 PMID: 10681343
  53. Mutations producing resistance to norfloxacin in Pseudomonas aeruginosa.
    Antimicrob Agents Chemother. 1987 Apr;31(4):582-6 PMID: 3111356
  54. The genome sequence of Rickettsia prowazekii and the origin of mitochondria.
    Nature. 1998 Nov 12;396(6707):133-40 PMID: 9823893
  55. Characterization of mechanisms of quinolone resistance in Pseudomonas aeruginosa strains isolated in vitro and in vivo during experimental endocarditis.
    Antimicrob Agents Chemother. 1989 May;33(5):624-34 PMID: 2502066
  56. Proportion of DNA gyrase mutants among quinolone-resistant strains of Pseudomonas aeruginosa.
    Antimicrob Agents Chemother. 1990 Jun;34(6):1273-5 PMID: 2168149
  57. Involvement of an active efflux system in the natural resistance of Pseudomonas aeruginosa to aminoglycosides.
    Antimicrob Agents Chemother. 1999 Nov;43(11):2624-8 PMID: 10543738
  58. Cloning and nucleotide sequence of the Pseudomonas aeruginosa nfxB gene, conferring resistance to new quinolones.
    FEMS Microbiol Lett. 1992 Oct 1;76(1-2):197-202 PMID: 1330820
  59. Occurrence of the nfxB type mutation in clinical isolates of Pseudomonas aeruginosa.
    Antimicrob Agents Chemother. 1992 Nov;36(11):2562-5 PMID: 1489207
  60. Role of the acrAB locus in organic solvent tolerance mediated by expression of marA, soxS, or robA in Escherichia coli.
    J Bacteriol. 1997 Oct;179(19):6122-6 PMID: 9324261
  61. NorM, a putative multidrug efflux protein, of Vibrio parahaemolyticus and its homolog in Escherichia coli.
    Antimicrob Agents Chemother. 1998 Jul;42(7):1778-82 PMID: 9661020
  62. Contribution of outer membrane efflux protein OprM to antibiotic resistance in Pseudomonas aeruginosa independent of MexAB.
    Antimicrob Agents Chemother. 1998 Jul;42(7):1682-8 PMID: 9661004
  63. Cross-resistance to meropenem, cephems, and quinolones in Pseudomonas aeruginosa.
    Antimicrob Agents Chemother. 1992 Sep;36(9):1847-51 PMID: 1416876
  64. The cobalt, zinc, and cadmium efflux system CzcABC from Alcaligenes eutrophus functions as a cation-proton antiporter in Escherichia coli.
    J Bacteriol. 1995 May;177(10):2707-12 PMID: 7751279
  65. Alignment and structure prediction of divergent protein families: periplasmic and outer membrane proteins of bacterial efflux pumps.
    J Mol Biol. 1999 Apr 2;287(3):695-715 PMID: 10092468
  66. Evidence that TolC is required for functioning of the Mar/AcrAB efflux pump of Escherichia coli.
    J Bacteriol. 1996 Oct;178(19):5803-5 PMID: 8824631
  67. Expression of Pseudomonas aeruginosa multidrug efflux pumps MexA-MexB-OprM and MexC-MexD-OprJ in a multidrug-sensitive Escherichia coli strain.
    Antimicrob Agents Chemother. 1998 Jan;42(1):65-71 PMID: 9449262
  68. nalB-type mutations causing the overexpression of the MexAB-OprM efflux pump are located in the mexR gene of the Pseudomonas aeruginosa chromosome.
    FEMS Microbiol Lett. 1999 Oct 1;179(1):67-72 PMID: 10481088
  69. The SMR family: a novel family of multidrug efflux proteins involved with the efflux of lipophilic drugs.
    Mol Microbiol. 1996 Mar;19(6):1167-75 PMID: 8730859
  70. AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants.
    J Bacteriol. 1996 Jan;178(1):306-8 PMID: 8550435
  71. The ABC family of multidrug transporters in microorganisms.
    Biochim Biophys Acta. 1998 Jun 10;1365(1-2):31-6 PMID: 9693718
  72. Cloning of multidrug resistance gene pqrA from Proteus vulgaris.
    Antimicrob Agents Chemother. 1995 Feb;39(2):453-7 PMID: 7726514
  73. Salicylate-inducible antibiotic resistance in Pseudomonas cepacia associated with absence of a pore-forming outer membrane protein.
    Antimicrob Agents Chemother. 1992 Oct;36(10):2280-5 PMID: 1280056
  74. Molecular analysis and nucleotide sequence of the envCD operon of Escherichia coli.
    Mol Gen Genet. 1991 Nov;230(1-2):230-40 PMID: 1720861
  75. Bacterium genome sequence.
    Nature. 1996 Jun 20;381(6584):653-4 PMID: 8649508
  76. The bacterial outer membrane as a drug barrier.
    Trends Microbiol. 1997 Jan;5(1):37-42 PMID: 9025234
  77. The acrAB homolog of Haemophilus influenzae codes for a functional multidrug efflux pump.
    J Bacteriol. 1997 Nov;179(21):6855-7 PMID: 9352940
  78. EnvC, a new lipoprotein of the cytoplasmic membrane of Escherichia coli.
    FEMS Microbiol Lett. 1993 Mar 1;107(2-3):175-8 PMID: 8472900
  79. Endogenous active efflux of norfloxacin in susceptible Escherichia coli.
    Antimicrob Agents Chemother. 1988 Aug;32(8):1187-91 PMID: 3056253
  80. AcrA is a highly asymmetric protein capable of spanning the periplasm.
    J Mol Biol. 1999 Jan 8;285(1):409-20 PMID: 9878415
  81. Plasmid-mediated tetracycline resistance in Escherichia coli involves increased efflux of the antibiotic.
    Biochem Biophys Res Commun. 1980 Mar 13;93(1):74-81 PMID: 6990931
  82. The outer membrane protein OprM of Pseudomonas aeruginosa is encoded by oprK of the mexA-mexB-oprK multidrug resistance operon.
    Antimicrob Agents Chemother. 1995 Nov;39(11):2567-9 PMID: 8585747
  83. Selection of multiple-antibiotic-resistant (mar) mutants of Escherichia coli by using the disinfectant pine oil: roles of the mar and acrAB loci.
    Antimicrob Agents Chemother. 1997 Dec;41(12):2770-2 PMID: 9420057
  84. Multiple antibiotic resistance in Stenotrophomonas maltophilia.
    Antimicrob Agents Chemother. 1997 May;41(5):1140-2 PMID: 9145884
  85. Quinolone resistance from a transferable plasmid.
    Lancet. 1998 Mar 14;351(9105):797-9 PMID: 9519952
  86. In vivo selection of Klebsiella pneumoniae strains with enhanced quinolone resistance during fluoroquinolone treatment of urinary tract infections.
    Antimicrob Agents Chemother. 1997 Jul;41(7):1609-11 PMID: 9210697
  87. Multidrug efflux in intrinsic resistance to trimethoprim and sulfamethoxazole in Pseudomonas aeruginosa.
    Antimicrob Agents Chemother. 1996 Oct;40(10):2288-90 PMID: 9036831
  88. Factors influencing the accumulation of ciprofloxacin in Pseudomonas aeruginosa.
    Antimicrob Agents Chemother. 1989 Nov;33(11):1921-6 PMID: 2514623
  89. Two novel families of bacterial membrane proteins concerned with nodulation, cell division and transport.
    Mol Microbiol. 1994 Mar;11(5):841-7 PMID: 8022262
  90. Outer membrane proteins responsible for multiple drug resistance in Pseudomonas aeruginosa.
    Antimicrob Agents Chemother. 1995 Mar;39(3):645-9 PMID: 7793866
  91. Outer membrane permeability of non-typable Haemophilus influenzae.
    J Antimicrob Chemother. 1996 Feb;37(2):341-4 PMID: 8707744
  92. Cloning and characterization of a DNA fragment that complements the nfxB mutation in Pseudomonas aeruginosa PAO.
    FEMS Microbiol Lett. 1991 Mar 15;63(1):31-5 PMID: 1904383
  93. Mechanisms of quinolone resistance in clinical isolates of Shigella dysenteriae.
    Antimicrob Agents Chemother. 1999 Sep;43(9):2333-4 PMID: 10577351
  94. Multidrug efflux pump AcrAB of Salmonella typhimurium excretes only those beta-lactam antibiotics containing lipophilic side chains.
    J Bacteriol. 1998 Sep;180(17):4686-92 PMID: 9721312
  95. Chloramphenicol resistance in Pseudomonas cepacia because of decreased permeability.
    Antimicrob Agents Chemother. 1989 Feb;33(2):136-41 PMID: 2719457
  96. nfxC-type quinolone resistance in a clinical isolate of Pseudomonas aeruginosa.
    Antimicrob Agents Chemother. 1995 Mar;39(3):790-2 PMID: 7793896
  97. Active efflux of ofloxacin by a highly quinolone-resistant strain of Proteus vulgaris.
    J Antimicrob Chemother. 1991 Dec;28(6):827-36 PMID: 1667782
  98. Role of mexA-mexB-oprM in antibiotic efflux in Pseudomonas aeruginosa.
    Antimicrob Agents Chemother. 1995 Sep;39(9):1948-53 PMID: 8540696
  99. Cloning and sequence analysis of an EnvCD homologue in Pseudomonas aeruginosa: regulation by iron and possible involvement in the secretion of the siderophore pyoverdine.
    Mol Microbiol. 1993 Nov;10(3):529-44 PMID: 7968531
  100. Inner membrane efflux components are responsible for beta-lactam specificity of multidrug efflux pumps in Pseudomonas aeruginosa.
    J Bacteriol. 1997 Dec;179(24):7875-81 PMID: 9401051
  101. Contributions of individual mechanisms to fluoroquinolone resistance in 36 Escherichia coli strains isolated from humans and animals.
    Antimicrob Agents Chemother. 1996 Oct;40(10):2380-6 PMID: 8891148
  102. Missense mutations that alter the DNA-binding domain of the MtrR protein occur frequently in rectal isolates of Neisseria gonorrhoeae that are resistant to faecal lipids.
    Microbiology. 1995 Apr;141 ( Pt 4):907-11 PMID: 7773394
  103. A multidrug resistance regulatory chromosomal locus is widespread among enteric bacteria.
    J Infect Dis. 1993 Aug;168(2):484-8 PMID: 8335992
  104. In vivo emergence of multidrug-resistant mutants of Pseudomonas aeruginosa overexpressing the active efflux system MexA-MexB-OprM.
    Antimicrob Agents Chemother. 1999 Feb;43(2):287-91 PMID: 9925520
  105. Ineffectiveness of topoisomerase mutations in mediating clinically significant fluoroquinolone resistance in Escherichia coli in the absence of the AcrAB efflux pump.
    Antimicrob Agents Chemother. 2000 Jan;44(1):10-3 PMID: 10602715
  106. Antibiotic resistance caused by gram-negative multidrug efflux pumps.
    Clin Infect Dis. 1998 Aug;27 Suppl 1:S32-41 PMID: 9710669
  107. The periplasmic murein peptide-binding protein MppA is a negative regulator of multiple antibiotic resistance in Escherichia coli.
    J Bacteriol. 1999 Aug;181(16):4842-7 PMID: 10438753
  108. A pleiotropic, posttherapy, enoxacin-resistant mutant of Pseudomonas aeruginosa.
    Antimicrob Agents Chemother. 1992 May;36(5):1057-61 PMID: 1510393
  109. Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents is modulated by the mtrRCDE efflux system.
    Microbiology. 1995 Mar;141 ( Pt 3):611-22 PMID: 7711899
  110. Overexpression of the mexC-mexD-oprJ efflux operon in nfxB-type multidrug-resistant strains of Pseudomonas aeruginosa.
    Mol Microbiol. 1996 Aug;21(4):713-24 PMID: 8878035
  111. Susceptibility of Xanthomonas maltophilia to six quinolones and study of outer membrane proteins in resistant mutants selected in vitro.
    Antimicrob Agents Chemother. 1992 Mar;36(3):669-71 PMID: 1622183
  112. The effect of sodium salicylate on antibiotic susceptibility and synergy in Klebsiella pneumoniae.
    J Antimicrob Chemother. 1990 Sep;26(3):343-51 PMID: 2228825
  113. Clinical applications of quinolones.
    Biochim Biophys Acta. 1998 Oct 1;1400(1-3):45-61 PMID: 9748496
  114. Differential selection of multidrug efflux systems by quinolones in Pseudomonas aeruginosa.
    Antimicrob Agents Chemother. 1997 Nov;41(11):2540-3 PMID: 9371363
  115. Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions.
    DNA Res. 1996 Jun 30;3(3):109-36 PMID: 8905231
  116. Drug resistance of Pseudomonas aeruginosa with special reference to new quinolones.
    Antibiot Chemother (1971). 1991;44:209-14 PMID: 1801639
  117. Cross-resistance to fluoroquinolones in multiple-antibiotic-resistant (Mar) Escherichia coli selected by tetracycline or chloramphenicol: decreased drug accumulation associated with membrane changes in addition to OmpF reduction.
    Antimicrob Agents Chemother. 1989 Aug;33(8):1318-25 PMID: 2679373
  118. Intrinsic resistance to inhibitors of fatty acid biosynthesis in Pseudomonas aeruginosa is due to efflux: application of a novel technique for generation of unmarked chromosomal mutations for the study of efflux systems.
    Antimicrob Agents Chemother. 1998 Feb;42(2):394-8 PMID: 9527792
  119. Negative regulation of the Pseudomonas aeruginosa outer membrane porin OprD selective for imipenem and basic amino acids.
    Antimicrob Agents Chemother. 1999 May;43(5):1085-90 PMID: 10223918
  120. Influence of OprM expression on multiple antibiotic resistance in Pseudomonas aeruginosa.
    Antimicrob Agents Chemother. 1997 Sep;41(9):2009-12 PMID: 9303403
  121. Efflux-mediated aminoglycoside and macrolide resistance in Burkholderia pseudomallei.
    Antimicrob Agents Chemother. 1999 Mar;43(3):465-70 PMID: 10049252
  122. Expression in Escherichia coli of a new multidrug efflux pump, MexXY, from Pseudomonas aeruginosa.
    Antimicrob Agents Chemother. 1999 Feb;43(2):415-7 PMID: 9925549
  123. Trends in bacterial resistance to fluoroquinolones.
    Clin Infect Dis. 1997 Jan;24 Suppl 1:S67-73 PMID: 8994781
  124. In vitro selected fluoroquinolone-resistant mutants of Citrobacter freundii: analysis of the quinolone resistance acquisition.
    J Antimicrob Chemother. 2000 Apr;45(4):521-4 PMID: 10747831
  125. Salicylate induction of antibiotic resistance in Escherichia coli: activation of the mar operon and a mar-independent pathway.
    J Bacteriol. 1993 Dec;175(24):7856-62 PMID: 7504664
  126. Use of fluorescence probes to monitor function of the subunit proteins of the MexA-MexB-oprM drug extrusion machinery in Pseudomonas aeruginosa.
    J Biol Chem. 1997 Aug 29;272(35):21964-9 PMID: 9268332
  127. Salmonella typhimurium acrB-like gene: identification and role in resistance to biliary salts and detergents and in murine infection.
    FEMS Microbiol Lett. 1996 Jan 15;135(2-3):161-7 PMID: 8595853
  128. Tetracycline resistance determinants: mechanisms of action, regulation of expression, genetic mobility, and distribution.
    FEMS Microbiol Rev. 1996 Oct;19(1):1-24 PMID: 8916553
  129. Proton-dependent multidrug efflux systems.
    Microbiol Rev. 1996 Dec;60(4):575-608 PMID: 8987357
  130. Outer membrane barrier as a mechanism of antimicrobial resistance.
    Antimicrob Agents Chemother. 1989 Nov;33(11):1831-6 PMID: 2692513
  131. Interplay between the MexA-MexB-OprM multidrug efflux system and the outer membrane barrier in the multiple antibiotic resistance of Pseudomonas aeruginosa.
    J Antimicrob Chemother. 2000 Apr;45(4):433-6 PMID: 10747818
  132. Genetic and physiological characterization of ciprofloxacin resistance in Pseudomonas aeruginosa PAO.
    Antimicrob Agents Chemother. 1988 Apr;32(4):535-9 PMID: 2837141
  133. A family of extracytoplasmic proteins that allow transport of large molecules across the outer membranes of gram-negative bacteria.
    J Bacteriol. 1994 Jul;176(13):3825-31 PMID: 8021163
  134. Improvement of organic solvent tolerance level of Escherichia coli by overexpression of stress-responsive genes.
    Extremophiles. 1998 Aug;2(3):239-48 PMID: 9783171
  135. Molecular cloning and characterization of acrA and acrE genes of Escherichia coli.
    J Bacteriol. 1993 Oct;175(19):6299-313 PMID: 8407802
  136. Multiple antibiotic resistance in Stenotrophomonas maltophilia: involvement of a multidrug efflux system.
    Antimicrob Agents Chemother. 2000 Feb;44(2):287-93 PMID: 10639352
  137. Active efflux and diffusion are involved in transport of Pseudomonas aeruginosa cell-to-cell signals.
    J Bacteriol. 1999 Feb;181(4):1203-10 PMID: 9973347
  138. Expression of the multidrug resistance operon mexA-mexB-oprM in Pseudomonas aeruginosa: mexR encodes a regulator of operon expression.
    Antimicrob Agents Chemother. 1996 Sep;40(9):2021-8 PMID: 8878574
  139. Active efflux of tetracycline encoded by four genetically different tetracycline resistance determinants in Escherichia coli.
    Proc Natl Acad Sci U S A. 1980 Jul;77(7):3974-7 PMID: 7001450
  140. MdfA, an Escherichia coli multidrug resistance protein with an extraordinarily broad spectrum of drug recognition.
    J Bacteriol. 1997 Apr;179(7):2274-80 PMID: 9079913
  141. Active efflux of bile salts by Escherichia coli.
    J Bacteriol. 1997 Apr;179(8):2512-8 PMID: 9098046
  142. Interactions of dedicated export membrane proteins of the colicin V secretion system: CvaA, a member of the membrane fusion protein family, interacts with CvaB and TolC.
    J Bacteriol. 1997 Oct;179(20):6264-70 PMID: 9335271
  143. Efflux pump of the proton antiporter family confers low-level fluoroquinolone resistance in Mycobacterium smegmatis.
    Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):362-6 PMID: 8552639
  144. Evidence for an efflux pump in multidrug-resistant Campylobacter jejuni.
    Antimicrob Agents Chemother. 1995 Sep;39(9):2019-22 PMID: 8540709
  145. Inhibitors of efflux pumps in Pseudomonas aeruginosa potentiate the activity of the fluoroquinolone antibacterial levofloxacin.
    J Med Chem. 1999 Dec 2;42(24):4928-31 PMID: 10585202
  146. Major facilitator superfamily.
    Microbiol Mol Biol Rev. 1998 Mar;62(1):1-34 PMID: 9529885
  147. Transport of pefloxacin across the bacterial cytoplasmic membrane in quinolone-susceptible Staphylococcus aureus.
    Antimicrob Agents Chemother. 1992 Nov;36(11):2506-11 PMID: 1489194
  148. Multiple antibiotic resistance (mar) locus protects Escherichia coli from rapid cell killing by fluoroquinolones.
    Antimicrob Agents Chemother. 1996 May;40(5):1266-9 PMID: 8723480
  149. Outer membrane alterations in multiresistant mutants of Pseudomonas aeruginosa selected by ciprofloxacin.
    Antimicrob Agents Chemother. 1989 Jan;33(1):124-7 PMID: 2496655
  150. Overexpression of the marA or soxS regulatory gene in clinical topoisomerase mutants of Escherichia coli.
    Antimicrob Agents Chemother. 1998 Aug;42(8):2089-94 PMID: 9687412
Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
Published
2000-09-00
Pages
2233-41
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC90051
Subset
IM
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]