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PMID: 1503431 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Active efflux mechanisms for antimicrobial resistance.

Antimicrobial agents and chemotherapy ·Vol. 36 ·No. 4 ·1992-04-00 ·Pages 695-703

Levy SB

Abstract

暂无摘要

MeSH Terms
4-Quinolones Anti-Infective Agents/pharmacology Bacteria/metabolism Drug Resistance, Microbial Tetracycline Resistance/physiology
Chemicals
4-Quinolones Anti-Infective Agents
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Levy S B
Department of Molecular Biology, Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts 02111.
References (88)
88 references, click to expand
  1. Sequential emergence of distinct resistance phenotypes in murine erythroleukemia cells under adriamycin selection: decreased anthracycline uptake precedes increased P-glycoprotein expression.
    Cancer Res. 1990 Dec 15;50(24):7895-901 PMID: 1979251
  2. Uptake of sparfloxacin and norfloxacin by clinical isolates of Staphylococcus aureus.
    Antimicrob Agents Chemother. 1991 Feb;35(2):368-70 PMID: 2024969
  3. Nucleotide sequence and overexpression of the tellurite-resistance determinant from the IncHII plasmid pHH1508a.
    Gene. 1991 May 15;101(1):1-7 PMID: 2060788
  4. Tet protein domains interact productively to mediate tetracycline resistance when present on separate polypeptides.
    J Bacteriol. 1991 Jul;173(14):4503-9 PMID: 2066343
  5. Efflux-mediated antiseptic resistance gene qacA from Staphylococcus aureus: common ancestry with tetracycline- and sugar-transport proteins.
    Mol Microbiol. 1990 Dec;4(12):2051-62 PMID: 2089219
  6. Cloning, nucleotide sequence, and expression of the chromate resistance determinant of Pseudomonas aeruginosa plasmid pUM505.
    J Bacteriol. 1990 Jan;172(1):287-91 PMID: 2152903
  7. Transport of divalent cations with tetracycline as mediated by the transposon Tn10-encoded tetracycline resistance protein.
    J Biol Chem. 1990 Mar 25;265(9):4809-13 PMID: 2156856
  8. A point mutation in norA gene is responsible for quinolone resistance in Staphylococcus aureus.
    Biochem Biophys Res Commun. 1990 Nov 15;172(3):1028-34 PMID: 2173911
  9. Nucleotide sequence and characterization of the Staphylococcus aureus norA gene, which confers resistance to quinolones.
    J Bacteriol. 1990 Dec;172(12):6942-9 PMID: 2174864
  10. Nucleotide sequence and expression of a plasmid-encoded chromate resistance determinant from Alcaligenes eutrophus.
    J Biol Chem. 1990 Apr 5;265(10):5648-53 PMID: 2180932
  11. Cloning of the ethidium efflux gene from Escherichia coli.
    FEMS Microbiol Lett. 1990 Mar 1;56(1-2):73-6 PMID: 2185131
  12. Interdomain hybrid Tet proteins confer tetracycline resistance only when they are derived from closely related members of the tet gene family.
    J Bacteriol. 1990 May;172(5):2303-12 PMID: 2185211
  13. Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum.
    Nature. 1990 May 17;345(6272):255-8 PMID: 2185424
  14. Transport systems encoded by bacterial plasmids.
    J Bioenerg Biomembr. 1990 Aug;22(4):493-507 PMID: 2229034
  15. Inducible erythromycin resistance in staphylococci is encoded by a member of the ATP-binding transport super-gene family.
    Mol Microbiol. 1990 Jul;4(7):1207-14 PMID: 2233255
  16. Gene duplication in the evolution of the two complementing domains of gram-negative bacterial tetracycline efflux proteins.
    Gene. 1990 Mar 1;87(1):7-13 PMID: 2332166
  17. Factors influencing the accumulation of ciprofloxacin in Pseudomonas aeruginosa.
    Antimicrob Agents Chemother. 1989 Nov;33(11):1921-6 PMID: 2514623
  18. Bacterial resistance ATPases: primary pumps for exporting toxic cations and anions.
    Trends Biochem Sci. 1989 Feb;14(2):76-80 PMID: 2523097
  19. Cadmium resistance from Staphylococcus aureus plasmid pI258 cadA gene results from a cadmium-efflux ATPase.
    Proc Natl Acad Sci U S A. 1989 May;86(10):3544-8 PMID: 2524829
  20. Topology of the transposon Tn10-encoded tetracycline resistance protein within the inner membrane of Escherichia coli.
    J Biol Chem. 1989 Jul 15;264(20):11663-70 PMID: 2545678
  21. Cloning of pMOL28-encoded nickel resistance genes and expression of the genes in Alcaligenes eutrophus and Pseudomonas spp.
    J Bacteriol. 1989 Sep;171(9):5071-8 PMID: 2549012
  22. P-glycoprotein and multidrug resistance in cancer chemotherapy.
    Semin Oncol. 1989 Apr;16(2):156-65 PMID: 2565605
  23. The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles.
    J Biol Chem. 1989 Jul 15;264(20):11693-8 PMID: 2568355
  24. Nucleotide sequence of a gene that encodes resistance to ethidium bromide from a transferable plasmid in Staphylococcus aureus.
    Nucleic Acids Res. 1989 Dec 11;17(23):10103 PMID: 2602117
  25. Amplification of a gene related to mammalian mdr genes in drug-resistant Plasmodium falciparum.
    Science. 1989 Jun 9;244(4909):1184-6 PMID: 2658061
  26. Evolution and spread of tetracycline resistance determinants.
    J Antimicrob Chemother. 1989 Jul;24(1):1-3 PMID: 2674098
  27. Expression and nucleotide sequence of a plasmid-determined divalent cation efflux system from Alcaligenes eutrophus.
    Proc Natl Acad Sci U S A. 1989 Oct;86(19):7351-5 PMID: 2678100
  28. Cross-resistance to fluoroquinolones in multiple-antibiotic-resistant (Mar) Escherichia coli selected by tetracycline or chloramphenicol: decreased drug accumulation associated with membrane changes in addition to OmpF reduction.
    Antimicrob Agents Chemother. 1989 Aug;33(8):1318-25 PMID: 2679373
  29. Physical and biochemical characterization of the qacA gene encoding antiseptic and disinfectant resistance in Staphylococcus aureus.
    J Gen Microbiol. 1989 Jan;135(1):1-10 PMID: 2778425
  30. Nucleotide sequence analysis reveals similarities between proteins determining methylenomycin A resistance in Streptomyces and tetracycline resistance in eubacteria.
    Gene. 1987;58(2-3):229-41 PMID: 2828187
  31. Plasmid-determined inducible efflux is responsible for resistance to cadmium, zinc, and cobalt in Alcaligenes eutrophus.
    J Bacteriol. 1989 Feb;171(2):896-900 PMID: 2914875
  32. Molecular cloning of tetracycline resistance genes from Streptomyces rimosus in Streptomyces griseus and characterization of the cloned genes.
    J Bacteriol. 1985 Mar;161(3):1010-6 PMID: 2982781
  33. Nucleotide sequence of the tetracycline resistance gene of pTHT15, a thermophilic Bacillus plasmid: comparison with staphylococcal TcR controls.
    Gene. 1985;37(1-3):131-8 PMID: 2996983
  34. Cation/proton antiport systems in Escherichia coli. Solubilization and reconstitution of delta pH-driven sodium/proton and calcium/proton antiporters.
    J Biol Chem. 1986 Jan 15;261(2):678-83 PMID: 3001076
  35. Nucleotide sequence of the R26 chloramphenicol resistance determinant and identification of its gene product.
    Gene. 1986;41(2-3):349-53 PMID: 3011609
  36. Cloning, expression in Escherichia coli and nucleotide sequence of a tetracycline-resistance gene from Streptomyces rimosus.
    J Gen Microbiol. 1988 Mar;134(3):585-98 PMID: 3053973
  37. Endogenous active efflux of norfloxacin in susceptible Escherichia coli.
    Antimicrob Agents Chemother. 1988 Aug;32(8):1187-91 PMID: 3056253
  38. Amplifiable resistance to tetracycline, chloramphenicol, and other antibiotics in Escherichia coli: involvement of a non-plasmid-determined efflux of tetracycline.
    J Bacteriol. 1983 Aug;155(2):531-40 PMID: 6348022
  39. A plasmid-encoded arsenite pump produces arsenite resistance in Escherichia coli.
    Biochem Biophys Res Commun. 1984 Nov 14;124(3):760-5 PMID: 6391481
  40. Susceptible Escherichia coli cells can actively excrete tetracyclines.
    Antimicrob Agents Chemother. 1983 Oct;24(4):544-51 PMID: 6418064
  41. Energy-dependent arsenate efflux: the mechanism of plasmid-mediated resistance.
    Proc Natl Acad Sci U S A. 1982 Oct;79(20):6114-8 PMID: 6755462
  42. Energetics of plasmid-mediated arsenate resistance in Escherichia coli.
    Proc Natl Acad Sci U S A. 1982 Oct;79(20):6119-22 PMID: 6755463
  43. Cation/proton antiport systems in Escherichia coli. Properties of the potassium/proton antiporter.
    J Biol Chem. 1980 Jan 10;255(1):39-44 PMID: 6985610
  44. Plasmid-mediated tetracycline resistance in Escherichia coli involves increased efflux of the antibiotic.
    Biochem Biophys Res Commun. 1980 Mar 13;93(1):74-81 PMID: 6990931
  45. Active efflux of tetracycline encoded by four genetically different tetracycline resistance determinants in Escherichia coli.
    Proc Natl Acad Sci U S A. 1980 Jul;77(7):3974-7 PMID: 7001450
  46. Energy-dependent efflux of cadmium coded by a plasmid resistance determinant in Staphylococcus aureus.
    J Bacteriol. 1981 Aug;147(2):313-9 PMID: 7263609
  47. DISAPPEARANCE OF OXYTETRACYCLINE ACCUMULATION IN THE CELLS OF MULTIPLE DRUG-RESISTANT ESCHERICHIA COLI.
    Nature. 1963 Oct 26;200:384-5 PMID: 14087909
  48. Proflavine Uptake and Release in Sensitive and Resistant Escherichia coli.
    J Bacteriol. 1968 Oct;96(4):1103-14 PMID: 16562158
  49. The cryptic tetracycline resistance determinant on Tn4400 mediates tetracycline degradation as well as tetracycline efflux.
    Antimicrob Agents Chemother. 1988 Dec;32(12):1797-800 PMID: 3072922
  50. Characterization of the tetracycline resistance gene of plasmid pT181 of Staphylococcus aureus.
    J Bacteriol. 1988 Dec;170(12):5522-8 PMID: 3142848
  51. Evidence that TET protein functions as a multimer in the inner membrane of Escherichia coli.
    J Bacteriol. 1988 Apr;170(4):1715-20 PMID: 3280550
  52. The phosphonium ion efflux system of Escherichia coli: relationship to the ethidium efflux system and energetic studies.
    J Gen Microbiol. 1986 Nov;132(11):3187-93 PMID: 3305782
  53. Efflux of chloroquine from Plasmodium falciparum: mechanism of chloroquine resistance.
    Science. 1987 Nov 27;238(4831):1283-5 PMID: 3317830
  54. Energy-dependent efflux mediated by class L (tetL) tetracycline resistance determinant from streptococci.
    Antimicrob Agents Chemother. 1987 Oct;31(10):1648-50 PMID: 3324958
  55. Reversal of chloroquine resistance in Plasmodium falciparum by verapamil.
    Science. 1987 Feb 20;235(4791):899-901 PMID: 3544220
  56. Vinblastine photoaffinity labeling of a high molecular weight surface membrane glycoprotein specific for multidrug-resistant cells.
    J Biol Chem. 1986 May 15;261(14):6137-40 PMID: 3700389
  57. Novel mechanism for plasmid-mediated erythromycin resistance by pNE24 from Staphylococcus epidermidis.
    Antimicrob Agents Chemother. 1986 Nov;30(5):653-8 PMID: 3800341
  58. Energetics of tetracycline efflux system encoded by Tn10 in Escherichia coli.
    FEBS Lett. 1985 Dec 2;193(2):194-8 PMID: 3905438
  59. Cation transport and electrogenesis by Streptococcus faecalis. II. Proton and sodium extrusion.
    J Membr Biol. 1972;8(1):45-62 PMID: 4263675
  60. Active transport of calcium in inverted membrane vesicles of Escherichia coli.
    Proc Natl Acad Sci U S A. 1974 Dec;71(12):5042-6 PMID: 4373740
  61. Detection of an inducible membrane protein associated with R-factor-mediated tetracycline resistance.
    Biochem Biophys Res Commun. 1974 Feb 27;56(4):1060-8 PMID: 4596957
  62. Proton/sodium ion antiport in Escherichia coli.
    Biochem J. 1974 Oct;144(1):87-90 PMID: 4618479
  63. Active outward transport of daunomycin in resistant Ehrlich ascites tumor cells.
    Biochim Biophys Acta. 1973 Oct 25;323(3):466-83 PMID: 4796512
  64. Adaptation of populations of Bacillus cereus to tetracycline.
    Mol Pharmacol. 1967 Nov;3(6):586-94 PMID: 4964702
  65. Acriflavine-binding capacity of Escherichia coli in relation to acriflavine sensitivity and metabolic activity.
    J Bacteriol. 1966 Nov;92(5):1447-52 PMID: 5332403
  66. Effect of mutation, electric membrane potential, and metabolic inhibitors on the accessibility of nucleic acids to ethidium bromide in Escherichia coli cells.
    Biochemistry. 1984 Jan 3;23(1):166-76 PMID: 6197994
  67. Two complementation groups mediate tetracycline resistance determined by Tn10.
    J Bacteriol. 1982 Jul;151(1):209-15 PMID: 6282805
  68. Analysis of tetracycline resistance encoded by transposon Tn10: deletion mapping of tetracycline-sensitive point mutations and identification of two structural genes.
    J Bacteriol. 1983 Feb;153(2):921-9 PMID: 6296060
  69. Gene in the major cotransduction gap of the Escherichia coli K-12 linkage map required for the expression of chromosomal resistance to tetracycline and other antibiotics.
    J Bacteriol. 1983 Aug;155(2):541-8 PMID: 6307967
  70. Intracistronic complementation of the tetracycline resistance membrane protein of Tn10.
    J Bacteriol. 1984 Jan;157(1):211-7 PMID: 6317652
  71. Cation/proton antiport systems in Escherichia coli. Properties of the calcium/proton antiporter.
    J Biol Chem. 1979 Mar 25;254(6):1957-63 PMID: 33991
  72. Cation/proton antiport systems in escherichia coli: properties of the sodium/proton antiporter.
    Arch Biochem Biophys. 1979 Apr 15;194(1):208-14 PMID: 36033
  73. Plasmid-determined tetracycline resistance involves new transport systems for tetracycline.
    Nature. 1978 Nov 2;276(5683):90-2 PMID: 368642
  74. Organization of structural and regulatory genes that mediate tetracycline resistance in transposon Tn10.
    J Bacteriol. 1979 Jun;138(3):705-14 PMID: 378932
  75. ATP-linked calcium transport in cells and membrane vesicles of Streptococcus faecalis.
    J Biol Chem. 1978 Apr 10;253(7):2085-92 PMID: 416023
  76. Mechanisms of resistance to daunorubicin in Ehrlich ascites tumor cells.
    Cancer Res. 1978 Jun;38(6):1785-91 PMID: 647687
  77. ATP-dependent cadmium transport by the cadA cadmium resistance determinant in everted membrane vesicles of Bacillus subtilis.
    J Bacteriol. 1992 Jan;174(1):116-21 PMID: 1530844
  78. Gene regulation of plasmid- and chromosome-determined inorganic ion transport in bacteria.
    Microbiol Rev. 1992 Mar;56(1):195-228 PMID: 1579110
  79. The multidrug efflux transporter of Bacillus subtilis is a structural and functional homolog of the Staphylococcus NorA protein.
    Antimicrob Agents Chemother. 1992 Feb;36(2):484-5 PMID: 1605617
  80. A staphylococcal multidrug resistance gene product is a member of a new protein family.
    Plasmid. 1992 Mar;27(2):119-29 PMID: 1615062
  81. Characterization of the nonenzymatic chloramphenicol resistance (cmlA) gene of the In4 integron of Tn1696: similarity of the product to transmembrane transport proteins.
    J Bacteriol. 1991 Jul;173(14):4493-502 PMID: 1648560
  82. Efflux-mediated multidrug resistance in Bacillus subtilis: similarities and dissimilarities with the mammalian system.
    Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4781-5 PMID: 1675788
  83. Structure and evolution of a family of genes encoding antiseptic and disinfectant resistance in Staphylococcus aureus.
    Gene. 1991 May 15;101(1):59-66 PMID: 1840534
  84. Mechanisms of fluoroquinolone resistance in Staphylococcus aureus.
    J Infect Dis. 1991 May;163(5):1080-6 PMID: 1850442
  85. The act cluster contains regulatory and antibiotic export genes, direct targets for translational control by the bldA tRNA gene of Streptomyces.
    Cell. 1991 Aug 23;66(4):769-80 PMID: 1878971
  86. A second gene in the Staphylococcus aureus cadA cadmium resistance determinant of plasmid pI258.
    J Bacteriol. 1991 Dec;173(23):7636-42 PMID: 1938959
  87. Role of an energy-dependent efflux pump in plasmid pNE24-mediated resistance to 14- and 15-membered macrolides in Staphylococcus epidermidis.
    Antimicrob Agents Chemother. 1990 Oct;34(10):1973-80 PMID: 1963291
  88. Mechanisms of multidrug resistance in HL60 cells: detection of resistance-associated proteins with antibodies against synthetic peptides that correspond to the deduced sequence of P-glycoprotein.
    Cancer Res. 1990 Mar 1;50(5):1426-30 PMID: 1967979
Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.36.4.695
Published
1992-04-00
Pages
695-703
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC189356
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.36.4.695 PMC Full Text View journal details
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