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PMID: 1830211 Published · ppublish English Journal Article Review

Iron and bacterial virulence--a brief overview.

Biology of metals ·Vol. 4 ·No. 1 ·1991-00-00 ·Pages 7-13

Griffiths E

Abstract

Iron is now recognized as playing a vital role in infection. Not only does it restricted availability in tissue fluids present microbial pathogens with the problem of acquiring sufficient for multiplication in vivo, but it also constitutes a major environmental signal which co-ordinately regulates the expression of a number of virulence and metabolic genes. Progress in understanding the strategies used by pathogens for acquiring iron in vivo, and their responses to iron restriction, is providing a fresh insight into microbial pathogenicity.

MeSH Terms
Bacteria/metabolism,pathogenicity Bacterial Infections/etiology Biological Transport, Active Heme/metabolism Humans Iron/metabolism Iron Chelating Agents/metabolism Siderophores Virulence/physiology
Chemicals
Iron Chelating Agents Siderophores Heme Iron
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Griffiths E
National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, UK.
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Article Info
Journal
Biology of metals
Abbr.
Biol Met
ISSN
0933-5854
DOI
10.1007/BF01135551
Published
1991-00-00
Pages
7-13
Language
English
Region
Germany
NLM ID
8915662
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01135551
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