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PMID: 19506576 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The genetic contribution to non-syndromic human obesity.

Nature reviews. Genetics ·Vol. 10 ·No. 7 ·2009-07-00 ·Pages 431-42

Walley AJ, Asher JE, Froguel P

Abstract

The last few years have seen major advances in common non-syndromic obesity research, much of it the result of genetic studies. This Review outlines the competing hypotheses about the mechanisms underlying the genetic and physiological basis of obesity, and then examines the recent explosion of genetic association studies that have yielded insights into obesity, both at the candidate gene level and the genome-wide level. With obesity genetics now entering the post-genome-wide association scan era, the obvious question is how to improve the results obtained so far using single nucleotide polymorphism markers and how to move successfully into the other areas of genomic variation that may be associated with common obesity.

MeSH Terms
Genetic Markers Genome, Human Humans Obesity/genetics Polymorphism, Single Nucleotide
Chemicals
Genetic Markers
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Walley Andrew J
Section of Genomic Medicine, Imperial College London, Burlington-Danes Building, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK. [email protected]
Asher Julian E
Froguel Philippe
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Article Info
Journal
Nature reviews. Genetics
Abbr.
Nat Rev Genet
ISSN
1471-0064
DOI
10.1038/nrg2594
Email
[email protected]
Published
2009-07-00
Pages
431-42
Language
English
Region
England
NLM ID
100962779
Subset
IM
Grants
Medical Research Council · G0600331 · United Kingdom
Wellcome Trust · United Kingdom
External Links
PubMed source DOI: 10.1038/nrg2594 View journal details
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