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PMID: 19888215 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Review

Applications of genome-scale metabolic reconstructions.

Molecular systems biology ·Vol. 5 ·2009-00-00 ·Pages 320

Oberhardt MA, Palsson BØ, Papin JA

Abstract

The availability and utility of genome-scale metabolic reconstructions have exploded since the first genome-scale reconstruction was published a decade ago. Reconstructions have now been built for a wide variety of organisms, and have been used toward five major ends: (1) contextualization of high-throughput data, (2) guidance of metabolic engineering, (3) directing hypothesis-driven discovery, (4) interrogation of multi-species relationships, and (5) network property discovery. In this review, we examine the many uses and future directions of genome-scale metabolic reconstructions, and we highlight trends and opportunities in the field that will make the greatest impact on many fields of biology.

MeSH Terms
Biological Evolution Genetic Engineering Genome/genetics Metabolic Networks and Pathways/genetics Models, Genetic
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Oberhardt Matthew A
Department of Biomedical Engineering, University of Virginia, Health System, Charlottesville, VA, USA.
Palsson Bernhard Ø
Papin Jason A
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Article Info
Journal
Molecular systems biology
Abbr.
Mol Syst Biol
ISSN
1744-4292
DOI
10.1038/msb.2009.77
Published
2009-00-00
Epub
2009-00-03
Pages
320
Language
English
Region
England
NLM ID
101235389
PMCID
PMC2795471
Subset
IM
Grants
NIGMS NIH HHS · T32 GM008715 · United States
NIGMS NIH HHS · GM08715 · United States
External Links
PubMed source DOI: 10.1038/msb.2009.77 PMC Full Text View journal details
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