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PMID: 22305607 Published · ppublish English Journal Article Research Support, American Recovery and Reinvestment Act Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

A new eye on NLR proteins: focused on clarity or diffused by complexity?

Current opinion in immunology ·Vol. 24 ·No. 1 ·2012-02-00 ·Pages 41-50

Bonardi V, Cherkis K, Nishimura MT, Dangl JL

Abstract

The nucleotide-binding domain leucine-rich repeat proteins (NLRs) represent the major class of intracellular innate immune receptors in plants and animals. Understanding their functions is a major challenge in immunology. This review highlights recent efforts toward elucidating NLR functions in human and plants. We compare unconventional aspects of NLR proteins across the two kingdoms. We review recent advances describing P-loop independent activation, nuclear-cytoplasmic trafficking, oligomerization and multimerization requirements for signaling, and for expanded functions beyond pathogen recognition by several NLR proteins.

MeSH Terms
Animals Apoptosis/immunology Carrier Proteins/immunology Humans Immunity, Innate/immunology Multigene Family Nod Signaling Adaptor Proteins/physiology Plant Proteins/immunology
Chemicals
Carrier Proteins Nod Signaling Adaptor Proteins Plant Proteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Bonardi Vera
Department of Biology, University of North Carolina, Chapel Hill, NC 27599-3280, USA.
Cherkis Karen
Nishimura Marc T
Dangl Jeffery L
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Article Info
Journal
Current opinion in immunology
Abbr.
Curr Opin Immunol
ISSN
1879-0372
DOI
10.1016/j.coi.2011.12.006
Published
2012-02-00
Epub
2012-00-03
Pages
41-50
Language
English
Region
England
NLM ID
8900118
PMCID
PMC3482489
Subset
IM
Grants
NIGMS NIH HHS · R01 GM066025 · United States
NIGMS NIH HHS · R01 GM057171 · United States
Howard Hughes Medical Institute · United States
NIGMS NIH HHS · R01GM066025 · United States
NIGMS NIH HHS · R01GM057171 · United States
External Links
PubMed source DOI: 10.1016/j.coi.2011.12.006 PMC Full Text View journal details
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