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PMID: 22578496 Published · ppublish English Journal Article Review

Harnessing the power of the endosome to regulate neural development.

Neuron ·Vol. 74 ·No. 3 ·2012-05-10 ·Pages 440-51

Yap CC, Winckler B

Abstract

Endocytosis and endosomal trafficking play a multitude of roles in cellular function beyond regulating entry of essential nutrients. In this review, we discuss the cell biological principles of endosomal trafficking, the neuronal adaptations to endosomal organization, and the role of endosomal trafficking in neural development. In particular, we consider how cell fate decisions, polarity, migration, and axon outgrowth and guidance are influenced by five endosomal tricks: dynamic modulation of receptor levels by endocytosis and recycling, cargo-specific responses via cargo-specific endocytic regulators, cell-type-specific endocytic regulation, ligand-specific endocytic regulation, and endosomal regulation of ligand processing and trafficking.

MeSH Terms
Animals Endocytosis/physiology Endosomes/physiology Humans Models, Biological Neurogenesis/physiology Neurons/physiology,ultrastructure Protein Transport/physiology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Yap Chan Choo
Department of Neuroscience, University of Virginia, 409 Lane Road, Charlottesville, VA 22908, USA.
Winckler Bettina
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Article Info
Journal
Neuron
Abbr.
Neuron
ISSN
1097-4199
DOI
10.1016/j.neuron.2012.04.015
Published
2012-05-10
Pages
440-51
Language
English
Region
United States
NLM ID
8809320
PMCID
PMC3351757
Subset
IM
Grants
NIGMS NIH HHS · R01 GM086913 · United States
External Links
PubMed source DOI: 10.1016/j.neuron.2012.04.015 PMC Full Text View journal details
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