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PMID: 24895166 Published · ppublish English Journal Article

The Multifaceted Roles Neutrophils Play in the Tumor Microenvironment.

Cancer microenvironment : official journal of the International Cancer Microenvironment Society ·Vol. 8 ·No. 3 ·2015-12-00 ·Pages 125-58

Sionov RV, Fridlender ZG, Granot Z

Abstract

Neutrophils are myeloid cells that constitute 50-70 % of all white blood cells in the human circulation. Traditionally, neutrophils are viewed as the first line of defense against infections and as a major component of the inflammatory process. In addition, accumulating evidence suggest that neutrophils may also play a key role in multiple aspects of cancer biology. The possible involvement of neutrophils in cancer prevention and promotion was already suggested more than half a century ago, however, despite being the major component of the immune system, their contribution has often been overshadowed by other immune components such as lymphocytes and macrophages. Neutrophils seem to have conflicting functions in cancer and can be classified into anti-tumor (N1) and pro-tumor (N2) sub-populations. The aim of this review is to discuss the varying nature of neutrophil function in the cancer microenvironment with a specific emphasis on the mechanisms that regulate neutrophil mobilization, recruitment and activation.

Keywords
Chemokines Neutrophil function Pre-metastatic niche Tumor Microenvironment
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Sionov Ronit Vogt
Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel Canada, Hebrew University Medical School, 91120, Jerusalem, Israel.
Fridlender Zvi G
Institute of Pulmonary Medicine, Hadassah-Hebrew University Medical Center, 96920, Jerusalem, Israel.
Granot Zvi
Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel Canada, Hebrew University Medical School, 91120, Jerusalem, Israel. [email protected].
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Article Info
Journal
Cancer microenvironment : official journal of the International Cancer Microenvironment Society
Abbr.
Cancer Microenviron
ISSN
1875-2292
DOI
10.1007/s12307-014-0147-5
Email
[email protected]
Published
2015-12-00
Epub
2014-00-04
Pages
125-58
Language
English
Region
Netherlands
NLM ID
101322634
PMCID
PMC4714999
External Links
PubMed source DOI: 10.1007/s12307-014-0147-5 PMC Full Text
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