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PMID: 2511434 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Requirement of upstream activation sequences for nitrogen catabolite repression of the allantoin system genes in Saccharomyces cerevisiae.

Molecular and cellular biology ·Vol. 9 ·No. 12 ·1989-12-00 ·Pages 5440-4

Cooper TG, Rai R, Yoo HS

Abstract

Synthesis of the transport systems and enzymes mediating uptake and catabolism of nitrogenous compounds is sensitive to nitrogen catabolite repression. In spite of the widespread occurrence of the control process, little is known about its mechanism. We have previously demonstrated that growth of cells on repressive nitrogen sources results in a dramatic decrease in the steady-state levels of mRNA encoded by the allantoin and arginine catabolic pathway genes and of the transport systems associated with allantoin metabolism. The present study identified the upstream activation sequences in the 5'-flanking regions of the allantoin system genes as the cis-acting sites through which nitrogen catabolite repression is exerted.

MeSH Terms
Allantoin/metabolism Arginine/metabolism Base Sequence Chromosome Deletion Gene Expression Regulation, Fungal Genes, Fungal Molecular Sequence Data Nitrogen/metabolism Plasmids RNA, Messenger/genetics Regulatory Sequences, Nucleic Acid Saccharomyces cerevisiae/genetics Transcription, Genetic beta-Galactosidase/genetics
Chemicals
RNA, Messenger Allantoin Arginine beta-Galactosidase Nitrogen
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Cooper T G
Department of Microbiology and Immunology, University of Tennessee, Memphis 38163.
Rai R
Yoo H S
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24 references, click to expand
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.9.12.5440-5444.1989
Published
1989-12-00
Pages
5440-4
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC363712
Subset
IM
Grants
NIGMS NIH HHS · R01 GM035642 · United States
NIGMS NIH HHS · GM-19386 · United States
NIGMS NIH HHS · GM-35536 · United States
NIGMS NIH HHS · GM-35642 · United States
External Links
PubMed source DOI: 10.1128/mcb.9.12.5440-5444.1989 PMC Full Text View journal details
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