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PMID: 2852997 Published · ppublish English Journal Article Review

Use of plasmid profiles in epidemiologic surveillance of disease outbreaks and in tracing the transmission of antibiotic resistance.

Clinical microbiology reviews ·Vol. 1 ·No. 2 ·1988-04-00 ·Pages 228-43

Mayer LW

Abstract

Plasmids are circular deoxyribonucleic acid molecules that exist in bacteria, usually independent of the chromosome. The study of plasmids is important to medical microbiology because plasmids can encode genes for antibiotic resistance or virulence factors. Plasmids can also serve as markers of various bacterial strains when a typing system referred to as plasmid profiling, or plasmid fingerprinting is used. In these methods partially purified plasma deoxyribonucleic acid species are separated according to molecular size by agarose gel electrophoresis. In a second procedure, plasmid deoxyribonucleic acid which has been cleaved by restriction endonucleases can be separated by agarose gel electrophoresis and the resulting pattern of fragments can be used to verify the identity of bacterial isolates. Because many species of bacteria contain plasmids, plasmid profile typing has been used to investigate outbreaks of many bacterial diseases and to trace inter- and intra-species spread of antibiotic resistance.

MeSH Terms
Animals Bacterial Infections/epidemiology Bacteriological Techniques DNA Transposable Elements Disease Outbreaks Drug Resistance, Microbial/genetics Humans Plasmids
Chemicals
DNA Transposable Elements
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Mayer L W
Division of Bacterial Diseases, Center for Infectious Diseases, Atlanta, Georgia 30333.
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Article Info
Journal
Clinical microbiology reviews
Abbr.
Clin Microbiol Rev
ISSN
0893-8512
DOI
10.1128/CMR.1.2.228
Published
1988-04-00
Pages
228-43
Language
English
Region
United States
NLM ID
8807282
PMCID
PMC358044
Subset
IM
External Links
PubMed source DOI: 10.1128/CMR.1.2.228 PMC Full Text View journal details
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