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PMID: 8264639 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Maf nuclear oncoprotein recognizes sequences related to an AP-1 site and forms heterodimers with both Fos and Jun.

Molecular and cellular biology ·Vol. 14 ·No. 1 ·1994-01-00 ·Pages 700-12

Kataoka K, Noda M, Nishizawa M

Abstract

The v-maf oncogene, identified from AS42 avian retrovirus, encodes a nuclear bZip protein. To elucidate the molecular mechanism of cell transformation induced by this oncogene, we determined the specific binding sequences of its product. Maf protein recognized two types of relatively long palindromic consensus sequences, TGCTGACTCAGCA and TGCTGACGTCAGCA, at roughly equal efficiency. The middle parts of these Maf-binding sequences completely match with two binding sequences for AP-1 transcription factor, i.e., phorbol 12-O-tetradecanoate-13-acetate (TPA)-responsive element (TRE) and cyclic AMP responsive element, suggesting partial overlapping of the target genes for Maf and AP-1. Furthermore, Maf efficiently formed heterodimers with the components of AP-1, Fos and Jun, through their leucine zipper structures, and these heterodimers show binding specificities distinct from those for Maf-Maf and Jun-Jun homodimers. Thus, a multiple combination of the dimers should generate a greatly expanded repertoire of transcriptional regulatory potential. DNA data base search for the Maf-binding consensus sequences suggested that some of the TRE-like cis elements reported previously may actually be the targets for Maf family proteins or their heterodimers with other bZip proteins.

MeSH Terms
Animals Base Sequence Binding Sites/genetics Cloning, Molecular Consensus Sequence DNA/genetics,metabolism DNA-Binding Proteins/metabolism Humans Leucine Zippers/genetics Molecular Sequence Data Oncogene Protein p65(gag-jun)/genetics,metabolism Oncogene Protein v-maf Oncogene Proteins, Viral/metabolism Proto-Oncogene Proteins c-fos/genetics,metabolism Proto-Oncogene Proteins c-jun/metabolism Recombinant Fusion Proteins/genetics,metabolism Retroviridae/genetics,metabolism Viral Proteins
Chemicals
DNA-Binding Proteins Oncogene Protein p65(gag-jun) Oncogene Protein v-maf Oncogene Proteins, Viral Proto-Oncogene Proteins c-fos Proto-Oncogene Proteins c-jun Recombinant Fusion Proteins Viral Proteins DNA
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Kataoka K
Department of Viral Oncology, Cancer Institute, Tokyo, Japan.
Noda M
Nishizawa M
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.14.1.700-712.1994
Published
1994-01-00
Pages
700-12
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC358419
Subset
IM
External Links
PubMed source DOI: 10.1128/mcb.14.1.700-712.1994 PMC Full Text View journal details
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