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Novel delayed-early and highly insulin-induced growth response genes. Identification of HRS, a potential regulator of alternative pre-mRNA splicing.
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EMBO J. 1993 Dec;12(12):4715-26
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The SR protein B52/SRp55 is essential for Drosophila development.
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Identification of a putative RNA helicase (HRH1), a human homolog of yeast Prp22.
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A systematic analysis of the factors that determine the strength of pre-mRNA splicing enhancers.
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An SC35-like protein and a novel serine/arginine-rich protein interact with Arabidopsis U1-70K protein.
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An exonic enhancer is required for inclusion of an essential exon in the SMA-determining gene SMN.
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Functional recognition of the 3' splice site AG by the splicing factor U2AF35.
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A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro.
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The essential pre-mRNA splicing factor SF2 influences 5' splice site selection by activating proximal sites.
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Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells.
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Molecular cloning of a novel human cdc2/CDC28-like protein kinase.
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Characterization of a Drosophila protein associated with boundaries of transcriptionally active chromatin.
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A conserved family of nuclear phosphoproteins localized to sites of polymerase II transcription.
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An ATP-independent complex commits pre-mRNA to the mammalian spliceosome assembly pathway.
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Two members of a conserved family of nuclear phosphoproteins are involved in pre-mRNA splicing.
Proc Natl Acad Sci U S A. 1992 Feb 15;89(4):1301-4
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Cloning and domain structure of the mammalian splicing factor U2AF.
Nature. 1992 Feb 13;355(6361):609-14
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The 35-kDa mammalian splicing factor SC35 mediates specific interactions between U1 and U2 small nuclear ribonucleoprotein particles at the 3' splice site.
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Isolation of a complementary DNA that encodes the mammalian splicing factor SC35.
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The SRm160/300 splicing coactivator is required for exon-enhancer function.
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An element in the 5' common exon of the NCAM alternative splicing unit interacts with SR proteins and modulates 5' splice site selection.
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Srp2, an SR protein family member of fission yeast: in vivo characterization of its modular domains.
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Curr Opin Cell Biol. 1999 Jun;11(3):358-62
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Evidence for the function of an exonic splicing enhancer after the first catalytic step of pre-mRNA splicing.
Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10655-60
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The protein kinase Clk/Sty directly modulates SR protein activity: both hyper- and hypophosphorylation inhibit splicing.
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Genes Dev. 1999 Sep 15;13(18):2425-38
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Identification of a bidirectional splicing enhancer: differential involvement of SR proteins in 5' or 3' splice site activation.
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Genes Dev. 1993 Dec;7(12B):2598-608
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The role of specific protein-RNA and protein-protein interactions in positive and negative control of pre-mRNA splicing by Transformer 2.
Cell. 1994 Feb 25;76(4):735-46
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Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors.
Nature. 1994 Mar 10;368(6467):119-24
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Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3363-7
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Conservation of regulated alternative splicing and identification of functional domains in vertebrate homologs to the Drosophila splicing regulator, suppressor-of-white-apricot.
J Biol Chem. 1994 Jun 10;269(23):16170-9
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SWAP pre-mRNA splicing regulators are a novel, ancient protein family sharing a highly conserved sequence motif with the prp21 family of constitutive splicing proteins.
Nucleic Acids Res. 1994 Oct 25;22(21):4510-9
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Purification and characterization of a kinase specific for the serine- and arginine-rich pre-mRNA splicing factors.
Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):10824-8
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Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases.
J Mol Biol. 1994 Dec 16;244(5):665-72
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Exon recognition in vertebrate splicing.
J Biol Chem. 1995 Feb 10;270(6):2411-4
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Modulation of 5' splice site choice in pre-messenger RNA by two distinct steps.
Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2504-8
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A two-step mechanism for 5' and 3' splice-site pairing.
Nature. 1995 Jun 8;375(6531):510-3
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A putative mammalian RNA helicase with an arginine-serine-rich domain colocalizes with a splicing factor.
J Biol Chem. 1995 Jun 30;270(26):15702-6
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Enhancer-dependent interaction between 5' and 3' splice sites in trans.
Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):7056-9
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EMBO J. 1995 Jul 17;14(14):3540-51
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Identification of a plant serine-arginine-rich protein similar to the mammalian splicing factor SF2/ASF.
Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7672-6
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U1 snRNP-ASF/SF2 interaction and 5' splice site recognition: characterization of required elements.
Nucleic Acids Res. 1995 Aug 25;23(16):3260-7
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Identification and characterization of three members of the human SR family of pre-mRNA splicing factors.
EMBO J. 1995 Sep 1;14(17):4336-49
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A U6 snRNA:pre-mRNA interaction can be rate-limiting for U1-independent splicing.
Genes Dev. 1995 Sep 15;9(18):2314-23
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Intrinsic U2AF binding is modulated by exon enhancer signals in parallel with changes in splicing activity.
RNA. 1995 Mar;1(1):21-35
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Overexpression of the SR proteins ASF/SF2 and SC35 influences alternative splicing in vivo in diverse ways.
RNA. 1995 May;1(3):335-46
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The superfamily of arginine/serine-rich splicing factors.
RNA. 1995 Sep;1(7):663-80
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SR proteins escort the U4/U6.U5 tri-snRNP to the spliceosome.
RNA. 1995 Sep;1(7):692-706
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The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution.
EMBO J. 1996 Jan 15;15(2):265-75
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Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):3074-9
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Specific phosphorylation of SR proteins by mammalian DNA topoisomerase I.
Nature. 1996 May 2;381(6577):80-2
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Genes Dev. 1996 Jun 1;10(11):1356-68
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Initial splice-site recognition and pairing during pre-mRNA splicing.
Curr Opin Genet Dev. 1996 Apr;6(2):215-20
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Assembly of specific SR protein complexes on distinct regulatory elements of the Drosophila doublesex splicing enhancer.
Genes Dev. 1996 Aug 15;10(16):2089-101
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A human homologue of the Drosophila sex determination factor transformer-2 has conserved splicing regulatory functions.
Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):9004-9
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Functional properties of p54, a novel SR protein active in constitutive and alternative splicing.
Mol Cell Biol. 1996 Oct;16(10):5400-8
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Targeted disruption of an essential vertebrate gene: ASF/SF2 is required for cell viability.
Genes Dev. 1996 Oct 15;10(20):2588-99
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Control of male sexual behavior and sexual orientation in Drosophila by the fruitless gene.
Cell. 1996 Dec 13;87(6):1079-89
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Characterization of a novel arginine/serine-rich splicing factor in Arabidopsis.
Plant Cell. 1996 Dec;8(12):2255-64
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Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing.
Genes Dev. 1997 Feb 1;11(3):334-44
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Sequence-specific RNA binding by an SR protein requires RS domain phosphorylation: creation of an SRp40-specific splicing enhancer.
Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1148-53
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The [U4/U6.U5] tri-snRNP-specific 27K protein is a novel SR protein that can be phosphorylated by the snRNP-associated protein kinase.
RNA. 1997 Apr;3(4):344-55
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A specific RNA hairpin loop structure binds the RNA recognition motifs of the Drosophila SR protein B52.
Mol Cell Biol. 1997 May;17(5):2649-57
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RNA splicing specificity determined by the coordinated action of RNA recognition motifs in SR proteins.
Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3596-601
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Cross-intron bridging interactions in the yeast commitment complex are conserved in mammals.
Cell. 1997 May 2;89(3):403-12
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The dynamics of a pre-mRNA splicing factor in living cells.
Nature. 1997 May 29;387(6632):523-7
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Bimolecular exon ligation by the human spliceosome.
Science. 1997 Jun 13;276(5319):1712-6
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Molecular cloning of htra2-beta-1 and htra2-beta-2, two human homologs of tra-2 generated by alternative splicing.
DNA Cell Biol. 1997 Jun;16(6):679-90
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The human U5 snRNP-specific 100-kD protein is an RS domain-containing, putative RNA helicase with significant homology to the yeast splicing factor Prp28p.
RNA. 1997 Nov;3(11):1313-26
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A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm.
Genes Dev. 1998 Jan 1;12(1):55-66
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Identification and characterization of srp1, a gene of fission yeast encoding a RNA binding domain and a RS domain typical of SR splicing factors.
Nucleic Acids Res. 1998 Jan 15;26(2):505-11
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SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells.
J Cell Biol. 1998 Feb 23;140(4):737-50
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Human homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicing.
EMBO J. 1998 Apr 1;17(7):2095-106
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A coactivator of pre-mRNA splicing.
Genes Dev. 1998 Apr 1;12(7):996-1009
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Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing.
Cell. 1998 Apr 3;93(1):139-48
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Regulation of adenovirus alternative RNA splicing by dephosphorylation of SR proteins.
Nature. 1998 May 14;393(6681):185-7
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Common themes in the function of transcription and splicing enhancers.
Curr Opin Cell Biol. 1997 Jun;9(3):350-7
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Role of the constitutive splicing factors U2AF65 and SAP49 in suboptimal RNA splicing of novel retroviral mutants.
J Biol Chem. 1998 Jun 12;273(24):15169-76
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